White matter alterations associated with suicide in patients with schizophrenia or schizophreniform disorder

Lee, Sung–Jae; Kim, Borah; Oh, Daeyoung; Kim, Minkyoung; Kim, Keun-Hyang; Bang, Seong Yun; Choi, Tai Kiu; Lee, Sanghyuk

doi:10.1016/j.pscychresns.2016.01.011

Cited by 22 publications

(10 citation statements)

References 37 publications

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“…Since global efficiency was inversely related to the path length between nodes, shorter path length ( L ) and greater global efficiency may share a common network characteristic. Global efficiency in the brain network is defined as “a measure of the overall capacity for parallel information transfer and integrated processing ( Bullmore and Sporns, 2012 ).” Increased efficiency of the brain network is supposed to be relevant to increased FA of white matter as reported in previous publications with suicide attempters ( Kim et al, 2015 ; Lee et al, 2016 ; Lopez-Larson et al, 2013 ). Local connections in rich club organization which were also found to be increased in suicide attempters, have been described as composed of more short-range fibers than the rich club and feeder connections ( van den Heuvel et al, 2012 ).…”

Section: Discussionmentioning

confidence: 63%

Increased efficiency of brain connectivity networks in veterans with suicide attempts

Hwang

Legarreta

Bueler

et al. 2018

NeuroImage: Clinical

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BackgroundSuicide is a public health concern for United States veterans and civilians. Prior research has shown neurobiological factors in suicide. However, studies of neuroimaging correlates of suicide risk have been limited. This study applied complex weighted network analyses to characterize the neural connectivity in white matter in veterans with suicide behavior.MethodsTwenty-eight veterans without suicide behavior (NS), 29 with a history of suicidal ideation only (SI), and 23 with prior suicide attempt (SA) completed diffusion tensor brain imaging, the Columbia Suicide Severity Rating Scale and Barratt Impulsiveness Scale (BIS). Structural connectivity networks among 82 parcellated brain regions were produced using whole-brain tractography. Global and nodal metrics of network topology have been calculated.ResultsSA had shorter characteristic path length and greater global efficiency and mean weighted degree of global network metrics (p < 0.024). SA had more hub nodes than NS and SI. The left posterior cingulate cortex (PCC) showed significantly greater weighted degree in SA relative to others (p < 0.0003). Nonplanning subscale of BIS correlated with the weighted degrees of the left PCC within SA. In rich club connectivity, SA had higher local connections than others (p = 0.001).ConclusionVeterans with prior suicide attempt had altered connectivity networks characteristics in the white matter. These findings may be distinctive neurobiological markers for individuals with suicide attempt. Strong connectivity in the left PCC may be implicated in impulsivity in veterans with suicide attempt.

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Section: Discussionmentioning

confidence: 63%

Increased efficiency of brain connectivity networks in veterans with suicide attempts

Hwang

Legarreta

Bueler

et al. 2018

NeuroImage: Clinical

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“…FA reductions in the posterior thalamic radiation in schizophrenia patients have also been identified across different image processing analyses (White et al., 2013) and have reportedly been linked to distorted self-perception (Lee et al, 2016). Reduced FA in the corpus callosum of schizophrenia patients are also well documented and have been found to be associated with psychotic symptom severity (Whitford et al, 2010; Knoechel et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study

Oestreich

Lyall

Pasternak

et al. 2017

Schizophrenia Research

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Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inconsistent patterns of white matter abnormalities. These studies have typically used the conventional measure of fractional anisotropy, which can be contaminated by extracellular free-water. A recent free-water imaging study reported reduced free-water corrected fractional anisotropy (FAT) in chronic schizophrenia across several brain regions, but limited changes in the extracellular volume. The present study set out to validate these findings in a substantially larger sample. Tract-based spatial statistics (TBSS) was performed in 188 healthy controls and 281 chronic schizophrenia patients. Forty-two regions of interest (ROIs), as well as average whole-brain FAT and FW were extracted from free-water corrected diffusion tensor maps. Compared to healthy controls, reduced FAT was found in the chronic schizophrenia group in the anterior limb of the internal capsule bilaterally, the posterior thalamic radiation bilaterally, as well as the genu and body of the corpus callosum. While a significant main effect of group was observed for FW, none of the follow-up contrasts survived correction for multiple comparisons. The observed FAT reductions in the absence of extracellular FW changes, in a large, multi-site sample of chronic schizophrenia patients, validate the pattern of findings reported by a previous, smaller free-water imaging study of a similar sample. The limited number of regions in which FAT was reduced in the schizophrenia group suggests that actual white matter tissue degeneration in chronic schizophrenia, independent of extracellular FW, might be more localized than suggested previously.

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“…Abnormal projections to the OFC and thalamus are linked to disrupted affective and cognitive functions representing an elevated vulnerability for suicidal behaviour [45]. Conversely, higher FA values are found in fronto-temporo-limbic circuits among suicide attempters diagnosed with schizophrenia or schizophreniform disorder [46]. In a younger study population with bipolar disorder, decreased WM integrity in the uncinate fasciculus, ventral frontal and right cerebellum regions; the CC and amygdala is associated with suicide attempts [18,47].…”

Section: Structural Neuroimagingmentioning

confidence: 99%

Neural substrates of suicide and suicidal behaviour: from a neuroimaging perspective

Balcıoğlu

Köse

2018

Psychiatry and Clinical Psychopharmacology

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In this article, we have reviewed neuroimaging studies on the neural circuitry associated with suicidal behaviour in order to identify the neural substrates of suicidal behaviour. The Medline and ScienceDirect databases were comprehensively and systematically searched and articles published from 1990 through 2017 were reviewed. Reviewed brain-imaging modalities included structural magnetic resonance imaging, diffusion tensor imaging, positron-emission tomography, single-photon emission computed tomography, resting-state functional Imaging, and functional magnetic resonance imaging. Although subject characteristics and imaging methods vary across studies, convergent findings involving the structure and function of frontostriatal network and fronto-limbic structures, and the serotonergic system were identified. These neuroimaging studies of suicide behaviour have provided crucial information on the neural circuitry associated with suicide risk. Future studies examining neural changes associated with before and after pharmacologic and behavioural interventions would be instrumental in suicide risk reduction.

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White matter alterations associated with suicide in patients with schizophrenia or schizophreniform disorder

Cited by 22 publications

References 37 publications

Increased efficiency of brain connectivity networks in veterans with suicide attempts

Increased efficiency of brain connectivity networks in veterans with suicide attempts

Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study

Neural substrates of suicide and suicidal behaviour: from a neuroimaging perspective

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