Whey protein concentrate limits venous thrombosis in rats

Tokajuk, Anna; Zakrzeska, Agnieszka; Chabielska, Ewa; Car, Halina

doi:10.1139/apnm-2018-0788

Cited by 4 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 or 0. 5 g/kg) for 7, 14, or 21 days to see how it affected the development of thrombosis, and it was found that there were minor changes in andour findings are consistent with those (Tokajuk et al, 2019).…”

Section: Discussionsupporting

confidence: 60%

Effects of whey-enriched drinking water on fattening merino lamb growth, hemogram, inflammation, oxidant and antioxidant parameters

Danyer,

Bilal,

Altiner

et al. 2024

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

This study aimed to evaluate the oxidative stress and inflammation status of ad libitum whey consumption as drinking water on fatting Merino lambs (n=24). Lambs were randomly divided into two groups and received ad libitum freshwater or whey enriched water and had clover as roughage and lamb grower feed as concentrate daily. Blood samples were collected before the trial (T1), on the 15th (T2) and 30th (T3) days and analyses were conducted on hemogram, serum antioxidant enzymes (Superoxide dismutase, SOD; Glutathione peroxidase, GSH-Px) inflammation response (C-Reactive Protein, CRP), complement activation, and chemokine marker (complement component 4, C4), lymphocyte activation factor (Interleukin 1 beta, IL-1 β), systemic inflammation cytokine (Tumor necrosis factor-alpha, TNF-α), lipid peroxidation marker (Malondialdehyde, MDA). The rate of hematocrit was found to be higher in the experimental group in T3 (35.55 ± 10.54) compared to the control group (44.50 ± 2.58). The platelet amounts were found to be higher in the whey group in T2 and T3 compared to the control group (p<0.05). In conclusion, with the use of whey protein-enriched drinking water, no significant change was observed in the amounts of TNF-α, SOD, MDA, IL-1β, C4, CRP under these study conditions.

show abstract

Section: Discussionsupporting

confidence: 60%

Effects of whey-enriched drinking water on fattening merino lamb growth, hemogram, inflammation, oxidant and antioxidant parameters

Danyer,

Bilal,

Altiner

et al. 2024

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

show abstract

“…More precisely, Singh et al [ 28 ] found that whey protein and its components—lactalbumin and lactoferrin—improved energy balance and glycemic control against the onset of neurological deficits associated with stroke. Bioactive peptides from milk proteins were also responsible for the limitation of thrombosis [ 29 ] through their angiotensin convertase enzyme inhibitory potential, which might partly explain why the effect was found mainly for mortality from cerebral infarction in the current study.…”

Section: Discussionmentioning

confidence: 90%

Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study—A Bayesian Survival Analysis

et al. 2020

View full text Add to dashboard Cite

The aim of this study was to further examine the relationship between milk intake and stroke mortality among the Japanese population. We used data from the Japan Collaborative Cohort (JACC) Study (total number of participants = 110,585, age range: 40–79) to estimate the posterior acceleration factors (AF) as well as the hazard ratios (HR) comparing individuals with different milk intake frequencies against those who never consumed milk at the study baseline. These estimations were computed through a series of Bayesian survival models that employed a Markov Chain Monte Carlo simulation process. In total, 100,000 posterior samples were generated separately through four independent chains after model convergency was confirmed. Posterior probabilites that daily milk consumers had lower hazard or delayed mortality from strokes compared to non-consumers was 99.0% and 78.0% for men and women, respectively. Accordingly, the estimated posterior means of AF and HR for daily milk consumers were 0.88 (95% Credible Interval, CrI: 0.81, 0.96) and 0.80 (95% CrI: 0.69, 0.93) for men and 0.97 (95% CrI: 0.88, 1.10) and 0.95 (95% CrI: 0.80, 1.17) for women. In conclusion, data from the JACC study provided strong evidence that daily milk intake among Japanese men was associated with delayed and lower risk of mortality from stroke especially cerebral infarction.

show abstract

“…Previous studies also indicated that α ‐lactalbumin could inhibit venous thrombosis. [ 47 ] and the coagulation was not initiated when the blood was exposed to materials with negatively charged surfaces such as misfolded proteins (unfolded BLA). [ 48 ] which was in accordance with our findings.…”

Section: Resultsmentioning

confidence: 99%

A Tumoricidal Lipoprotein Complex Electrostatically Stabilized on Mesoporous Silica as Nanotherapeutics and Nanoadjuvant for Potentiating Immunotherapy of Triple Negative Breast Cancer

Pei,

Li,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

As the most aggressive subtype, triple‐negative breast cancer (TNBC) without definitive targets represents a high probability of metastasis. Nevertheless, the presence of high‐level tumor‐infiltrating lymphocytes in the TNBC tumor microenvironment (TME) suggests patients may benefit from immunotherapy. In this study, bovine α‐lactalbumin coupled with oleic acid that forms tumoricidal lipid–protein complex (BAMLET) is electrostatically stabilized on the surface of amino‐functionalized mesoporous silica nanoparticles (MSN‐NH2). It is found that MSN‐NH2 may cause partial conformational changes of immobilized proteins due to electrostatic interactions. Therefore, BAMLET covered MSN‐NH2 (BMSN) as a drug cargo that can not only induce selectively oncolytic effect but kill tumor cells with rapid kinetics. Moreover, the hemolytic activity of BMSN conjugated with pre‐formed serum protein corona is largely reduced which may avoid the poor hemocompatibility caused by BAMLET. Furthermore, the in vivo study indicates that the combinational use of drug‐loaded BMSN and immune checkpoint small‐molecule inhibitor can efficiently inhibit the growth of solid TNBC tumors and activate immune response by sufficient infiltration of immune cells in the TME and prevent the seeding of circulating tumor cells. Therefore, the constructed BMSN provides an integrated nanotherapeutics and a nanoadjuvant with superior anticancer performance to combat TNBC.

show abstract

Whey protein concentrate limits venous thrombosis in rats

Cited by 4 publications

References 26 publications

Effects of whey-enriched drinking water on fattening merino lamb growth, hemogram, inflammation, oxidant and antioxidant parameters

Effects of whey-enriched drinking water on fattening merino lamb growth, hemogram, inflammation, oxidant and antioxidant parameters

Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study—A Bayesian Survival Analysis

A Tumoricidal Lipoprotein Complex Electrostatically Stabilized on Mesoporous Silica as Nanotherapeutics and Nanoadjuvant for Potentiating Immunotherapy of Triple Negative Breast Cancer

Contact Info

Product

Resources

About