2016
DOI: 10.1111/bdi.12414
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Abstract: Recently, a paper by Jacoby et al. 1 titled 'Glycogen synthase kinase-3β in patients with bipolar I disorder-results from a prospective study' was published in Bipolar Disorders. Glycogen synthase kinase (GSK)-3β is a kinase ubiquitously abundant in mammalian tissues, in general, and in the brain, in particular. 2,3 GSK-3β regulates the activity of multiple proteins involved in regulation of gene expression, apoptosis, survival pathways, inflammation, autophagy and neuronal plasticity. 2,4-7 Klein and Melton 8… Show more

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Cited by 3 publications
(2 citation statements)
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“…Lithium’s therapeutic efficacy might be due to its properties to lengthen the circadian period, which was observed across several species (Klemfuss 1992; Kripke et al 1978). One well-studied potential target of lithium’s action is the inhibition of glycogen synthase kinase-3 beta (GSK-3β) (Klein and Melton 1996; Serretti et al 2009; but see also Agam and Azab 2016). GSK-3β is involved in various cell functions, like gene transcription, neurogenesis, and apoptosis (Doble and Woodgett 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Lithium’s therapeutic efficacy might be due to its properties to lengthen the circadian period, which was observed across several species (Klemfuss 1992; Kripke et al 1978). One well-studied potential target of lithium’s action is the inhibition of glycogen synthase kinase-3 beta (GSK-3β) (Klein and Melton 1996; Serretti et al 2009; but see also Agam and Azab 2016). GSK-3β is involved in various cell functions, like gene transcription, neurogenesis, and apoptosis (Doble and Woodgett 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Two main hypotheses have been suggested to explain the therapeutic mechanism of action of Li: inositol monophosphatase-1 inhibition incurring consequential inositol depletion [ 36 , 37 ], and glycogen synthase kinase (GSK)-3β inhibition giving way to multiple cell signaling aftereffects [ 38 , 39 ]. However, despite appreciable recognition, neither theory has been accepted beyond doubt [ 40 , 41 ]. Li influences other cellular targets, affecting neurotransmission and second messenger signaling [ 42 ], enhancing autophagy [ 43 , 44 ], and impacting protein kinase C function [ 45 ], to name a few.…”
Section: Introductionmentioning
confidence: 99%