When Does the Failure to Find a Difference Mean That There Is None?

Non-penetrating deep sclerectomy without or with autologous scleral implant in open-angle glaucoma: medium-term results

“…We conclude that in our study we found no statistically significant difference between the two groups, NPDS without and with autologous scleral implant. This means that either there was truly no difference in outcome between the groups, or that the study failed to detect an actual difference [11]. Since the difference in postoperative IOP found between the groups was very small (0.3 mmHg), we would have needed 4200 patients in each arm to have a power of 80%.…”

Non-penetrating deep sclerectomy without or with autologous scleral implant in open-angle glaucoma: medium-term results

“…We conclude that in our study we found no statistically significant difference between the two groups, NPDS without and with autologous scleral implant. This means that either there was truly no difference in outcome between the groups, or that the study failed to detect an actual difference [11]. Since the difference in postoperative IOP found between the groups was very small (0.3 mmHg), we would have needed 4200 patients in each arm to have a power of 80%.…”

Efficacy and Tolerability of Nonpenetrating Filtering Surgery With and Without Implant in Treatment of Open Angle Glaucoma

“…A third limitation of this metaanalysis is that much of the clinical trials included in the analysis are not randomized, but retrospective or prospective nonrandomized, which may fail to detect actual results. 21 Our sensitivity analysis found that retrospective studies resulted a worse IOP lowering effect of NPFSI, but prospective nonrandomized and randomized trials resulted better effects. In future, randomized controlled trial seems to be recommended to further evaluate the effect of NPFSI.…”

Bilateral paediatric cataract surgery in the same session

“…Furthermore, neither has any case of endophthalmitis been previously reported after BPCS in one session, nor have we encountered any in our study population. However, this may not be considered as valid evidence because of the rarity of this problem 15 and the lower prevalence of paediatric cataract surgery. Additionally, a younger child in an amblyopia-susceptible period with bilateral significant cataract should have two consecutive surgeries with the shortest possible interval such as a few days, whereas this brief period cannot guarantee for eliminating the risk of bilateral acute-onset endophthalmitis that may not be diagnosed up to 21 days postoperatively.…”

Non-penetrating deep sclerectomy without or with autologous scleral implant in open-angle glaucoma: medium-term results

“…We conclude that in our study we found no statistically significant difference between the two groups, NPDS without and with autologous scleral implant. This means that either there was truly no difference in outcome between the groups, or that the study failed to detect an actual difference [11]. Since the difference in postoperative IOP found between the groups was very small (0.3 mmHg), we would have needed 4200 patients in each arm to have a power of 80%.…”

Efficacy and Tolerability of Nonpenetrating Filtering Surgery With and Without Implant in Treatment of Open Angle Glaucoma

“…A third limitation of this metaanalysis is that much of the clinical trials included in the analysis are not randomized, but retrospective or prospective nonrandomized, which may fail to detect actual results. 21 Our sensitivity analysis found that retrospective studies resulted a worse IOP lowering effect of NPFSI, but prospective nonrandomized and randomized trials resulted better effects. In future, randomized controlled trial seems to be recommended to further evaluate the effect of NPFSI.…”

Bilateral paediatric cataract surgery in the same session

“…Furthermore, neither has any case of endophthalmitis been previously reported after BPCS in one session, nor have we encountered any in our study population. However, this may not be considered as valid evidence because of the rarity of this problem 15 and the lower prevalence of paediatric cataract surgery. Additionally, a younger child in an amblyopia-susceptible period with bilateral significant cataract should have two consecutive surgeries with the shortest possible interval such as a few days, whereas this brief period cannot guarantee for eliminating the risk of bilateral acute-onset endophthalmitis that may not be diagnosed up to 21 days postoperatively.…”

Non-penetrating deep sclerectomy without or with autologous scleral implant in open-angle glaucoma: medium-term results

“…We conclude that in our study we found no statistically significant difference between the two groups, NPDS without and with autologous scleral implant. This means that either there was truly no difference in outcome between the groups, or that the study failed to detect an actual difference [11]. Since the difference in postoperative IOP found between the groups was very small (0.3 mmHg), we would have needed 4200 patients in each arm to have a power of 80%.…”

Efficacy and Tolerability of Nonpenetrating Filtering Surgery With and Without Implant in Treatment of Open Angle Glaucoma

“…A third limitation of this metaanalysis is that much of the clinical trials included in the analysis are not randomized, but retrospective or prospective nonrandomized, which may fail to detect actual results. 21 Our sensitivity analysis found that retrospective studies resulted a worse IOP lowering effect of NPFSI, but prospective nonrandomized and randomized trials resulted better effects. In future, randomized controlled trial seems to be recommended to further evaluate the effect of NPFSI.…”

Bilateral paediatric cataract surgery in the same session

“…Furthermore, neither has any case of endophthalmitis been previously reported after BPCS in one session, nor have we encountered any in our study population. However, this may not be considered as valid evidence because of the rarity of this problem 15 and the lower prevalence of paediatric cataract surgery. Additionally, a younger child in an amblyopia-susceptible period with bilateral significant cataract should have two consecutive surgeries with the shortest possible interval such as a few days, whereas this brief period cannot guarantee for eliminating the risk of bilateral acute-onset endophthalmitis that may not be diagnosed up to 21 days postoperatively.…”