2008
DOI: 10.1183/09031936.00066307
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Abstract: Childhood asthma is frequently perceived as a disease with uniform clinical pathways. This perception might be an oversimplification. The aim of the present study was to investigate the incidence and natural course of wheeze over the first 13 yrs of life and analyse the risk factors predicting wheeze at 11-13 yrs of age.The Multicentre Allergy Study, a German birth cohort, recruited 1,314 children in 1990. Physical examinations, interviews on atopic diseases, immunoglobulin (Ig)E and lung function tests were p… Show more

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Cited by 150 publications
(163 citation statements)
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References 26 publications
(29 reference statements)
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“…SCOTT et al [1] have commented, in the light of outcomes of their ''Isle of Wight Birth Cohort study'' (IoWBC) [2,3], on our findings on the risk factors for asthma in the Multicentre Allergy Study (MAS) birth cohort study [4]. We agree that the two studies lead to similar conclusions in regard to early origins of persistent wheezing, heterogeneity of childhood wheezing and the relevance of an atopic background.…”
supporting
confidence: 63%
“…SCOTT et al [1] have commented, in the light of outcomes of their ''Isle of Wight Birth Cohort study'' (IoWBC) [2,3], on our findings on the risk factors for asthma in the Multicentre Allergy Study (MAS) birth cohort study [4]. We agree that the two studies lead to similar conclusions in regard to early origins of persistent wheezing, heterogeneity of childhood wheezing and the relevance of an atopic background.…”
supporting
confidence: 63%
“…Nosso estudo utilizou como critério de gravidade "epidemiológica" da asma, as respostas de maior gravidade referentes aos sintomas de asma disponíveis no questionário ISAAC, ou seja, o número máximo de exacerbações no ano (mais de 12) e de despertares noturnos por semana (mais de 1), bem como a dificuldade de pronunciar palavras completas nas crises. 17 , como mostrado em alguns estudos longitudinais 18,19 . Outra explicação possível para esse achado é ter ocorrido uma variação na percepção do sibilo, o que pode ocorrer em casos de doença mais leve 20 ou tratar-se de formas atípicas de asma como a variante tosse, que constitui um subgrupo de asmáticos que não manifestam a sibilância 21,22 .…”
Section: Discussionunclassified
“…Thirdly, the date of each episode could be precisely established, allowing for a high-resolution month-to-month analysis. Fourthly, the sample size is relatively large, as compared to questionnaire-based prospective birth cohort studies, and the rate of losses is quite small [2,3,13,14,[18][19][20].…”
Section: Limitations and Strengthsmentioning
confidence: 99%