Wheat receptor-kinase-like protein Stb6 controls gene-for-gene resistance to fungal pathogen Zymoseptoria tritici

Saintenac, Cyrille; Lee, Wing-Sham; Cambon, Florence; Rudd, J. J.; King, Robert C.; Marande, William; Powers, Stephen J.; Bergès, Hélène; Phillips, A. L.; Uauy, Cristóbal; Hammond‐Kosack, K. E.; Langin, Thierry; Kanyuka, K.

doi:10.1038/s41588-018-0051-x

Cited by 208 publications

(215 citation statements)

References 67 publications

(92 reference statements)

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“…However, recently discovered evidence of overlapping layers between PTI and ETI suggests that they may not be independent. This was exemplified by the wheat Stb6 gene, an R gene that specifies resistance to Zymoseptoria tritici but encodes a wall‐associated receptor kinase‐like protein similar to the receptors involved in PTI (Saintenac et al , 2018). Moreover, evidence of shared downstream signalling machinery between PTI and ETI also supports an integrative and continuous plant immunity (Tsuda and Katagiri, 2010).…”

Section: Resistance Types For Powdery Mildewmentioning

confidence: 99%

Mechanisms of powdery mildew resistance of wheat – a review of molecular breeding

et al. 2020

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Powdery mildew (Blumeria graminis f. sp. tritici) results in serious economic loss in wheat production. Exploration of plant resistance to wheat powdery mildew over several decades has led to the discovery of a wealth of resistance genes and quantitative trait loci (QTLs). We have provided a comprehensive summary of over 200 powdery mildew genes (permanently and temporarily designated genes) and QTLs reported in common bread wheat. This highlights the diverse and rich resistance sources that exist across all 21 chromosomes. To manage different data for breeders, here we also present a bridged mapping result from previously reported powdery mildew resistance genes and QTLs with the application of a published integrated wheat map. This will provide important insights to empower further breeding of powdery mildew resistant wheat via marker‐assisted selection (MAS).

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Section: Resistance Types For Powdery Mildewmentioning

confidence: 99%

Mechanisms of powdery mildew resistance of wheat – a review of molecular breeding

et al. 2020

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“…Much of this variation is studied through genetic populations composed of cultivars that differ for the trait(s) of interest. These include bi‐parental populations between two cultivars (Saintenac et al ., ), multi‐parent advanced generation inter‐cross (MAGIC) populations composed of between 4 and 16 cultivars (Huang et al ., ; Mackay et al ., ; Milner et al ., ; Dixon et al ., ), nested association mapping panels of multiple cultivars to a common parent (Jordan et al ., ), and association panels of 100 or more cultivars (Sukumaran et al ., ; Liu et al ., ). All of these types of populations are available in wheat and their relative merits are discussed elsewhere (Huang and Han, ).…”

Section: Use Of Natural Variation For Trait Discoverymentioning

confidence: 99%

Applying the latest advances in genomics and phenomics for trait discovery in polyploid wheat

2018

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Summary Improving traits in wheat has historically been challenging due to its large and polyploid genome, limited genetic diversity and in‐field phenotyping constraints. However, within recent years many of these barriers have been lowered. The availability of a chromosome‐level assembly of the wheat genome now facilitates a step‐change in wheat genetics and provides a common platform for resources, including variation data, gene expression data and genetic markers. The development of sequenced mutant populations and gene‐editing techniques now enables the rapid assessment of gene function in wheat directly. The ability to alter gene function in a targeted manner will unmask the effects of homoeolog redundancy and allow the hidden potential of this polyploid genome to be discovered. New techniques to identify and exploit the genetic diversity within wheat wild relatives now enable wheat breeders to take advantage of these additional sources of variation to address challenges facing food production. Finally, advances in phenomics have unlocked rapid screening of populations for many traits of interest both in greenhouses and in the field. Looking forwards, integrating diverse data types, including genomic, epigenetic and phenomics data, will take advantage of big data approaches including machine learning to understand trait biology in wheat in unprecedented detail.

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“…Coupled with frequent sexual recombination in Z. tritici (Banke et al , ; Welch et al , ), this has catered for the rapid evolution of fungal virulence, resistance to the major classes of fungicides (Lucas, ; Hayes et al , ; Dooley et al , ) and rapid breakdown of host resistance (Cowger et al , ; Stukenbrock & McDonald, ; McDonald & Stukenbrock, ; Haueisen et al , ). Ongoing research aimed at controlling STB disease involves a multipronged approach for understanding host–pathogen gene interactions, resistance breeding and the development of new fungicide mixtures (Adhikari et al ., 2004a,b; Brown et al , ; Heick et al , ; Kema et al , ; Saintenac et al , ).…”

Section: Septoria Tritici Blotchmentioning

confidence: 99%

A review of the known unknowns in the early stages of septoria tritici blotch disease of wheat

et al. 2019

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Septoria tritici blotch (STB) disease of wheat is caused by the fungal pathogen Zymoseptoria tritici. It is the most important foliar disease of wheat in western Europe and affects wheat cultivation worldwide. The combination of intensive fungicide usage, a polycyclic asexual life cycle and an active sexual cycle has led to the emergence of fungal strains resistant/tolerant to all the major classes of fungicides used in its control. The hallmark of this disease is a long, symptomless latent phase that precedes the onset of visible symptoms. Understanding the processes that occur during the symptomless phase of infection is paramount in developing alternative strategies for disease control; however, large gaps in our knowledge of the disease remain. The known unknowns of the latent stage of infection can be summarized in three questions. Does the fungus initiate or manipulate host defences to trigger programmed cell death in order to facilitate nutrient acquisition or is the host acting exclusively? Does the fungus feed during both the latent phase and the necrotrophic phase like a true hemibiotroph? Does the long latent phase serve a beneficial function for the fungus or is it simply an artefact of evolution? This review aims to distil observations made during studies that have directly or indirectly contributed to answering these questions and points towards their most likely answers.

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Wheat receptor-kinase-like protein Stb6 controls gene-for-gene resistance to fungal pathogen Zymoseptoria tritici

Cited by 208 publications

References 67 publications

Mechanisms of powdery mildew resistance of wheat – a review of molecular breeding

Mechanisms of powdery mildew resistance of wheat – a review of molecular breeding

Applying the latest advances in genomics and phenomics for trait discovery in polyploid wheat

A review of the known unknowns in the early stages of septoria tritici blotch disease of wheat

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