Wheat germ agglutinin anchored chitosan microspheres of reduced brominated derivative of noscapine ameliorated acute inflammation in experimental colitis

Kaur, Kamalpreet; Sodhi, Rupinder Kaur; Katyal, Anju; Aneja, Ritu; Jain, Upendra Kumar; Katare, Om Prakash; Madan, Jitender

doi:10.1016/j.colsurfb.2015.05.022

Cited by 25 publications

(8 citation statements)

References 51 publications

(60 reference statements)

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“…Furthermore, the bromated derivative of noscapine has about 5 to 40 times more potent effects than noscapine [ 25 ]. Again, this brominated derivative also inhibits toll-like receptor (TLR), tumour necrosis factor α (TNF- α ), and NO in human and mouse macrophages without causing toxicity [ 26 ]. Furthermore, brominated noscapine has potent anti-inflammatory activity in models of septic inflammation, inhibits inflammatory factors in a dose-dependent manner, and prevents the release of TNF- α and NO in human and mouse macrophages [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Another study on inflammatory bowel disease (ulcerative colitis) and colon cancer found that noscapine had an excellent anti-inflammatory effect that could significantly decrease the levels of proinflammatory factors such as IL-1 β , IFN- γ , and IL-6, compared to the control group [ 26 ]. Additionally, it has been found that chitosan nanoparticles containing brominated noscapine derivatives could reduce proinflammatory cytokines such as IL-1 β , IFN- γ , and IL-6 and inflammation within colon mucosal tissue [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review

Rahmanian-Devin

Rahimi

Jaafari

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Noscapine is a benzylisoquinoline alkaloid isolated from poppy extract, used as an antitussive since the 1950s, and has no addictive or euphoric effects. Various studies have shown that noscapine has excellent anti-inflammatory effects and potentiates the antioxidant defences by inhibiting nitric oxide (NO) metabolites and reactive oxygen species (ROS) levels and increasing total glutathione (GSH). Furthermore, noscapine has indicated antiangiogenic and antimetastatic effects. Noscapine induces apoptosis in many cancerous cell types and provides favourable antitumour activities and inhibitory cell proliferation in solid tumours, even drug-resistant strains, via mitochondrial pathways. Moreover, this compound attenuates the dynamic properties of microtubules and arrests the cell cycle in the G2/M phase. Noscapine can reduce endothelial cell migration in the brain by inhibiting endothelial cell activator interleukin 8 (IL-8). In fact, this study aimed to elaborate on the possible mechanisms of noscapine against different disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review

Rahmanian-Devin

Rahimi

Jaafari

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Wheat germ agglutinin (WGA) is an agglutinin protein which protects wheat from insects, yeast and bacteria. WGA could binds to N-acetyl-D-glucosamine and sialic acid with low toxicity to the normal tissues [15]. It was reported that WGA could enhance the transport ability across the BBB by receptor-mediated endocytosis [16], and the modification of WGA on nanoparticles could potentiate the targeting effects to tumor cells by the specifically binding to glycoproteins overexpressed on cytomembrane [17].…”

Section: Introductionmentioning

confidence: 99%

Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma

Xiao

Cheng

Xie

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Glioma is the most common primary malignant brain tumor with a poor prognosis. The application of chemotherapeutic drugs is limited due to the existence of blood-brain barrier and serious side effects. Liposomes have been proven to be a stable and useful drug delivery system for tumors. In this paper, WGA (wheat germ agglutinin) modified vinorelbine cationic liposomes had been successfully constructed for treating glioma. In the liposomes, WGA was modified on the liposomal surface for crossing the blood-brain barrier and increasing the targeting effects, 3-(N-(N 0 , N 0-dimethylaminoethane) carbamoyl) cholesterol (DC-Chol) was used as cationic material and vinorelbine was encapsulated in the aqueous core of liposomes to inhibit tumor metastasis and kill tumor cells. Studies were performed on C6 cells in vitro and were verified in brain glioma-bearing mice in vivo. Results in vitro demonstrated that the targeting liposomes could induce C6 cells apoptosis, promote drugs across the blood-brain barrier, inhibit the metastasis of tumor cells and increase targeting effects to tumor cells. Meanwhile, action mechanism studies showed that the targeting liposomes could down-regulate PI3K, MMP-2, MMP-9 and FAK to inhibit tumor metastasis. Results in vivo exhibited that the targeting liposomes displayed an obvious antitumor efficacy by accumulating selectively in tumor site and exhibited low toxicity to blood system and major organs. Hence, WGA modified vinorelbine cationic liposomes might provide a safe and efficient therapy strategy for glioma.

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“…NOS, ( Fig. 3 ) an opium alkaloid classically used as antitussive agent has been repositioned for its anti-tumor effect as it strongly binds to tubulin, arrests the cells in metaphase, induces apoptosis in the dividing human cells and has the advantage of large therapeutic window [ [116] , [117] , [118] , [119] , [120] , [121] , [122] ]. The antitussive effect of NOS is documented through suppression of bradykinin production or inhibition of its function through inhibition of B2 receptor thus preventing bronchoconstriction, mucous production and histamine release [ [123] , [124] ].…”

Section: Old Bullets For New Target: Drugs For Mitigating the Symptommentioning

confidence: 99%