Biochemical Pharmacology volume 82, issue 11, P1521-1527 2011 DOI: 10.1016/j.bcp.2011.07.061 View full text
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J.-L. Reymond, Ruud van Deursen, D. Bertrand

Abstract: The activity of ligand gated channels is crucial for proper brain function and dysfunction of a single receptor subtype have led to neurological impairments ranging from benign to major diseases such as epilepsy, startle diseases, etc. Molecular biology and crystallography allowed the characterization at the atomic scale of the first four transmembrane ligand gated channels and of proteins sharing a high degree of homology with the neurotransmitter-binding domain. Gaining an adequate knowledge of the structura…

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