What to feed or what not to feed-that is still the question

Abstract

Introduction This review addresses metabolic diversities after grain feeding of cattle using artificial total mixed ration (TMR), in place of pasture-based feeding. Objectives To determine how grain feeding impairs the deuterium-depleting functions of the anaplerotic mitochondrial matrix during milk and meat production. Methods Based on published data we herein evaluate how grain-fed animals essentially follow a branched-chain amino acid and odd-chain fatty acid-based reductive carboxylation-dependent feedstock, which is also one of the mitochondrial deuterium-accumulating dysfunctions in human cancer. Results It is now evident that food-based intracellular deuterium exchange reactions, especially that of glycogenic substrate oxidation, are significant sources of deuterium-enriched (2H; D) metabolic water with a significant impact on animal and human health. The burning of high deuterium nutritional dairy products into metabolic water upon oxidation in the human body may contribute to similar metabolic conditions and diseases as described in state-of-the-art articles for cows. Grain feeding also limits oxygen delivery to mitochondria for efficient deuterium-depleted metabolic water production by glyphosate herbicide exposure used in genetically modified crops of TMR constituents. Conclusion Developments in medical metabolomics, biochemistry and deutenomics, which is the science of biological deuterium fractionation and discrimination warrant urgent critical reviews in order to control the epidemiological scale of population diseases such as diabetes, obesity and cancer by a thorough understanding of how the compromised metabolic health of grain-fed dairy cows impacts human consumers.

Metabolic imprinting in beef calves supplemented with creep feeding on performance, reproductive efficiency and metabolome profile

“…Such changes hold significant implications for long-term productivity outcomes in beef cattle systems 34 , 53 , 54 . Reviewed by Lech et al 55 , the metabolic effects of different feeding regimes in Holstein–Friesian cows post-calving were evaluated, revealing distinct metabolic adaptations in grass-fed versus grain-fed cows. Grass-fed cows had a ketogenic metabolism characterized by lower deuterium content in fatty acid products, while grain-fed cows exhibit elevated deuterium levels due to carbohydrate and protein-rich diets.…”

A Magyar Honvédség élelmezés-ellátásának modernizációs lehetőségei

“…29 Hatással van a mitokondriumokban lejátszódó citromsavciklusra. 30,31 Jelentősége a sejtjeinkben jelenlevő mitokondrium membránjába integrált ATP termelésének hatékonyságában is kifejeződik. 32,33,34,35 Az ATP-szintáz speciális úton szelektálja, 36 de egy bizonyos D-tartalom felett a szűrés hatékonysága csökken, 37 és a magasabb D-tartalom károsíthatja működését.…”