What's new in acne? An analysis of systematic reviews published in 2011-2012

Bhate, Ketaki; Williams, Hywel C

doi:10.1111/ced.12270

Cited by 31 publications

(30 citation statements)

References 18 publications

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“…It is mainly considered an "adolescent" disorder and is characterized by spontaneous resolution in the late teens or early twenties in the majority of cases, in some of them with facial scar formation [2] . Prevalence of acne varies worldwide: studies published in the last decade reported prevalence ranging from 25.2%, among prepubertal children in Peru to 93.2 and 93.3% among adolescents in Iran and Australia [3] .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City

Duquia

Santos²,

Almeida³

et al. 2017

Dermatology

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Background: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors. Objective: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. Methods: A cross-sectional population-based study was conducted. A dermatologist performed the clinical examination of the face and trunk for identification of acne lesions. Acne was evaluated as clinically noninflammatory, inflammatory, and acne with both types of lesions. Skin color, schooling, height, smoking, skinfolds, waist circumference, BMI, and dietary dairy intake were the independent variables used. Results: A response rate of 97.2% was obtained. Individuals without any acne lesion were 241 (10.9%); 161 (7.3%) only had noninflammatory lesions, 404 (18.4%) only inflammatory lesions; and 1,395 (63.4%) presented both types of lesions. In multivariate analysis, the type of lesions was different in light and dark skin phototype adolescents, with more common inflammatory lesions in the light phototype and noninflammatory ones in the dark phototype patients. Height was directly associated with the occurrence of all types of acne, whereas lower fat mass was associated with the occurrence of noninflammatory acne. While daily consumption of whole milk or yogurt was found to be associated with inflammatory acne in crude analysis, the association with milk was not detected and that with yogurt was low in multivariate analysis. Conclusion: Our results suggest that future studies should explore determinants of noninflammatory and inflammatory acne separately, especially if mixed populations are studied.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City

Duquia

Santos²,

Almeida³

et al. 2017

Dermatology

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“…[344] However, they are not recommended as the first-line treatment for acne due to safety issues. [4455]…”

Section: Miscellaneous Agentsmentioning

confidence: 99%

Synchronizing pharmacotherapy in acne with review of clinical care

Sacchidanand¹,

Lahiri

Godse³

et al. 2017

Indian J Dermatol

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Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained. The present article discusses the available topical and oral acne therapies and the challenges associated with the overall management of acne in India and suggestions and recommendations by the Indian dermatologists. The experts opined that among topical therapies, the combination therapies are preferred over monotherapy due to associated lower efficacy, poor tolerability, safety issues, adverse effects, and emerging bacterial resistance. Retinoids are preferred in comedonal acne and as maintenance therapy. In case of poor response, combination therapies BPO-retinoid or retinoid-antibacterials in papulopustular acne and retinoid-BPO or BPO-antibacterials in pustular-nodular acne are recommended. Oral agents are generally recommended for severe acne. Low-dose retinoids are economical and have better patient acceptance. Antibiotics should be prescribed till the inflammation is clinically visible. Antiandrogen therapy should be given to women with high androgen levels and are added to regimen to regularize the menstrual cycle. In late-onset hyperandrogenism, oral corticosteroids should be used. The experts recommended that an early initiation of therapy is directly proportional to effective therapeutic outcomes and prevent complications.

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“…Bowe et al [106] however considered there is reasonably compelling evidence that a highly glycemic diet may exacerbate acne, the role of ω-3 fatty acids, antioxidants, zinc and vitamin A being unclear. Finally, in a recent overview Bhate and Williams [107] insisted on the weakness of the evidence that suggests a possible link between dairy products and acne.…”

Section: Seborrhea and Acne: Inseparable Players Of The Pathogenic Prmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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What's new in acne? An analysis of systematic reviews published in 2011-2012

Cited by 31 publications

References 18 publications

Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City

Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City

Synchronizing pharmacotherapy in acne with review of clinical care

Acne Pathogenesis: History of Concepts

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