What it takes to be at the top: The interrelationship between chronic social stress and social dominance

Šabanović, Merima; Liu, He; Mlambo, Vongai; Aqel, Hala; Chaudhury, Dipesh

doi:10.1002/brb3.1896

Cited by 18 publications

(14 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An additional factor that likely shapes the relationship between rank and stress susceptibility is the length of group housing prior to testing. Šabanović et al (2020) group-housed mice for two weeks before stress exposure, and in this case, they did not find any differences in stress susceptibility between ranks. This result in conjunction with ours importantly argues against innate resilience in dominants for males, but instead suggests there are advantages gained from both acquiring and maintaining a dominant position.…”

Section: Discussionmentioning

confidence: 72%

“…Our findings stand in contrast to prior work which revealed an opposite pattern of resilience by rank. Previously it has been demonstrated that the most dominant 50% of male mice are more stress susceptible to social defeat (Larrieu et al, 2017), while others have shown no relationship between rank and social stress susceptibility (Šabanović et al, 2020). Closer examination of the social landscape reveals potential explanations for these differences.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, hierarchies assessed from agonistic behavior in the cage may be more indicative of the behaviors displayed to establish hierarchy position rather than absolute hierarchy position in and of itself. Past work has also demonstrated that previously susceptible animals can still achieve a dominant position within a cage of novel animals; however external environmental stress may still serve to shape the continued dynamics of an established social hierarchy (Šabanović et al, 2020). Thus, close examination of social hierarchy position across time is vital in predicting animals’ stress susceptibility.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Individual history of winning and hierarchy landscape influence stress susceptibility in mice

LeClair

Chan

Kaster

et al. 2021

Preprint

View full text Add to dashboard Cite

Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we exposed ranked male and female mice to social and non-social stressors and manipulated social hierarchy position. We found that rank predicts same sex social stress outcomes: dominance in males and females confers resilience while subordination confers susceptibility. Pre-existing rank does not predict non-social stress outcomes in females and weakly does so in males, but rank emerging under stress conditions reveals social interaction deficits in male and female subordinates. Both history of winning and rank of cage mates affect stress susceptibility in males: rising to the top rank through high mobility confers resilience and mice that lose dominance lose stress resilience, though gaining dominance over a subordinate animal does not confer resilience. Overall, we have demonstrated a relationship between social status and stress susceptibility, particularly when taking into account individual history of winning and the overall hierarchy landscape in male and female mice.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Individual history of winning and hierarchy landscape influence stress susceptibility in mice

LeClair

Chan

Kaster

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…A two-stage social interaction test (SI) was performed in a square arena (40 cm × 40 cm) with artificially defined interaction zone (14 cm × 26 cm) and corner zones (10 cm × 10 cm) as we previously reported in both male and female mice (Takahashi et al, 2017;Šabanović et al, 2020). In the first test (target-absent), the experimental mouse was allowed to freely explore the arena with an empty wire mesh sleeve (10 cm × 6 cm) in the interaction zone.…”

Section: Social Interaction Testmentioning

confidence: 99%

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Zhao

et al. 2021

Front. Neurosci.

View full text Add to dashboard Cite

Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry- and pain-related behaviors are examined under physiological condition in female C57BL/6J mice over different estrous cycle phases: proestrus, estrous, metestrous, diestrous. Our behavioral results reveal that there is no significant difference over different phases of the estrous cycle in social interaction test, sucrose preference test, tail suspension test, open field test, marble burying test, novelty-suppressed feeding test, Hargreaves thermal pain test, and Von Frey mechanical pain test. These findings implicate those psychiatry- and pain-related behaviors in normal female C57BL/6J mice appear to be relatively consistent throughout the estrous cycle; the estrous cycle might not be a main contributor to female C57BL/6J mice’s variability of behaviors.

show abstract

“…Social rank in a group of individuals constantly monitors one’s standing in relation to others and uses that information to guide behavior [ 4 ], such as access to resources and defending territories. Therefore, hierarchical rank has broad effects on physical and mental health due to the risk factors associated with living in a particular rank [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

2021

View full text Add to dashboard Cite

Impaired social behavior is a common feature of many psychiatric disorders, in particular with substance abuse disorders. Switching the preference of the substance-dependent individual toward social interaction activities remains one of the major challenges in drug dependence therapy. However, social interactions yield to the emergence of social ranking. In this review, we provide an overview of the studies that examined how social status can influence the dopaminergic mesolimbic system and how drug-seeking behavior is affected. Generally, social dominance is associated with an increase in dopamine D2/3 receptor binding in the striatum and a reduced behavioral response to drugs of abuse. However, it is not clear whether higher D2 receptor availability is a result of increased D2 receptor density and/or reduced dopamine release in the striatum. Here, we discuss the possibility of a potential shift from down to top rank via manipulation of the mesolimbic system. Identifying the neurobiology underlying a potential rank switch to a resilient phenotype is of particular interest in order to promote a positive coping behavior toward long-term abstinence from drugs of abuse and a protection against relapse to drugs. Such a shift may contribute to a more successful therapeutic approach to cocaine addiction.

show abstract

What it takes to be at the top: The interrelationship between chronic social stress and social dominance

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 18 publications

References 61 publications

Individual history of winning and hierarchy landscape influence stress susceptibility in mice

Individual history of winning and hierarchy landscape influence stress susceptibility in mice

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

Contact Info

Product

Resources

About