Infectious Disease Clinics of North America volume 27, issue 1, P87-97 2013 DOI: 10.1016/j.idc.2012.11.013 View full text
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Donald E. Low

Abstract: Multidrug-resistant pneumococci continue to increase worldwide. Although there are still questions regarding the relevance of β-lactam resistance, the recommendation for the use of the macrolides as monotherapy for mild community-acquired pneumonia should be revisited in view of high rates of resistance, the association of clinical failures with low-level and high-level resistance, and the lack of clinical data to support their need for empirical therapy for the atypicals.