What is the lifetime risk of developing cancer?: the effect of adjusting for multiple primaries

Sasieni, Peter; Shelton, Jon; Ormiston‐Smith, Nick; Thomson, Catherine S.; Silcocks, Paul

doi:10.1038/bjc.2011.250

Cited by 121 publications

(113 citation statements)

References 5 publications

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“…The main limitation of any lifetime risk study lies in the necessary assumption of time homogeneity of incidence and mortality rates [2,3]. Continuation of the increase in mean life expectancy, which has been steady for more than two centuries [19,26], will increase the lifetime risk of COPD hospitalisation.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…Lifetime risk estimates overcome this problem by summing up the spectrum of age-specific incidence rates and the rates of disease-free survival into one single number [2,3]. Such estimates are commonly used benchmarks with regard to other chronic diseases, such as cardiovascular disease and cancer, but they have not until recently been adopted in COPD [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Trends in the lifetime risk of COPD exacerbation requiring hospitalisation

et al. 2013

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This study aimed to estimate time trends in the lifetime risk of hospitalisation with exacerbation of chronic obstructive pulmonary disease (COPD) in Denmark.During the period from 1994 to 2008, a register-based cohort study was conducted covering each subject in the entire population of Denmark (5.18 million in 2008). Based on previously validated diagnosis codes, all COPD hospitalisations were identified. Individual retrospective review periods of 8 years were used to determine first-time hospitalisations. From year 2002 to 2008, all first-time COPD hospitalised subjects aged o30 years were identified. The calculation of lifetime risk was based on age-and sex-specific first-time COPD hospitalisation rates and rates of COPD hospitalisation-free survival, assuming them to be calendar time stationary.The study included 23.9 million person-years of risk time and identified 48 959 first-time COPD hospitalisations. For 30-year-olds in Denmark, the lifetime risk of COPD hospitalisation was 12.0% (95% CI 11.9-12.2) for females and 10.9% (95% CI 10.8-11.1) for males. Trends were generally equal in both sexes.During the period from 2002 to 2008, the rate of first-time COPD hospitalisations decreased, while the survival of never COPD hospitalised subjects increased. In consequence, the lifetime risk of COPD hospitalisation remained constant. @ERSpublications A 10% lifetime risk of COPD hospitalisation remains constant

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Section: Strengths and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trends in the lifetime risk of COPD exacerbation requiring hospitalisation

et al. 2013

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“…We decided to adjust for these confounders and additionally for other potential confounders that were a major risk factor (30% increased risk) for breast cancer and were found to be differentially associated with shift work. The final adjustment set therefore was: age (1,11,12), ethnicity (1,13,14), socioeconomic status (or a proxy) (10,(15)(16)(17), parity (16,(18)(19)(20)(21) with adjustment done for either number of children, or age at first child, and body mass index (BMI) (overweight, obese) (22)(23)(24).…”

Section: Confoundersmentioning

confidence: 99%

Night-shift work and breast cancer – a systematic review and meta-analysis

Ijaz¹,

Verbeek²,

Seidler³

et al. 2013

Scand J Work Environ Health

205

139

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“…Approximately 12% of women will experience breast cancer during their lifetime (1). Therefore, breast cancer maintains its importance as a serious public health issue.…”

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confidence: 99%

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

T¹,

G²,

Sezgin³

et al. 2016

Balkan Med J

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Background: Magnetic resonance imaging (MRI) has become a diagnostic and problem solving method for the breast examinations in addition to conventional breast examination methods. Diffusion-weighted imaging (DWI) adds valuable information to conventional MRI. Aims: Our aim was to show the impact of apparent diffusion coefficient (ADC) values acquired with DWI to differentiate benign and malignant breast lesions. Study Design: Diagnostic accuracy study. Methods: Forty-six women with 58 breast masses (35 malignant, 23 benign) were examined on a 1.5 T clinical MRI scanner. The morphologic characteristics of the lesions on conventional MRI sequences and contrast uptake pattern were assessed. ADC values of both lesions and normal breast parenchyma were measured. The ADC values obtained were statistically compared with the histopathologic results using Paired Samples t-Test. Results: Multiple lesions were detected in 12 (26%) of the patients, while only one lesion was detected in 34 (74%). Overall, 35 lesions out of 58 were histopathologically proven to be malignant. In the dynamic contrast-enhanced series, 5 of the malignant lesions were type 1, while 8 benign lesions revealed either type 2 or 3 time signal intensity curves (85% sensitivity, 56% spesifity Breast cancer is the most common cancer in females worldwide and the second main cause of cancer death following lung cancer. Approximately 12% of women will experience breast cancer during their lifetime (1). Therefore, breast cancer maintains its importance as a serious public health issue. The major risk factors comprise family history, genetic predisposition caused by the presence of a BRCA1 or BRCA2 gene mutation, and previously acquired breast lesions including fibrovascular papilloma, atypical ductal and lobular hyperplasia, and ductal and lobular carcinoma in situ (2,3).Imaging is crucial to diagnose and evaluate the stage and extent of breast cancer. Therefore, three types of radiologic techniques, including mammography, ultrasonography (US) and breast magnetic resonance imaging (MRI), are implemented. As a basic breast cancer scanning method, mammography is highly available, with a short scanning time.

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What is the lifetime risk of developing cancer?: the effect of adjusting for multiple primaries

Cited by 121 publications

References 5 publications

Trends in the lifetime risk of COPD exacerbation requiring hospitalisation

Trends in the lifetime risk of COPD exacerbation requiring hospitalisation

Night-shift work and breast cancer – a systematic review and meta-analysis

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

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