What is anxious depression? Overlap and agreement between different definitions

Effects of Anxious Depression on Antidepressant Treatment Response

“…Therefore, in our study we focused on pharmacotherapeutic effectiveness in high-level anxiety phenotypes. The relevance of anxiety in relation to depression has been a topic of interest for researchers since the 1960s and 1970s, when studies began exploring the heterogeneity of depression [21]. An anxiety factor or anxiety cluster was regularly identified [22,23].…”

“…The different definitions of anxious depression in particular seem to be a problem in the comparability of the results. For example, anxious depression has previously been defined as either a single anxiety disorder, any anxiety disorder, different anxiety disorders, scores on anxiety scales or scores on an anxiety factor of a depression scale [21].…”

Effects of Anxious Depression on Antidepressant Treatment Response

“…Therefore, in our study we focused on pharmacotherapeutic effectiveness in high-level anxiety phenotypes. The relevance of anxiety in relation to depression has been a topic of interest for researchers since the 1960s and 1970s, when studies began exploring the heterogeneity of depression [21]. An anxiety factor or anxiety cluster was regularly identified [22,23].…”

“…The different definitions of anxious depression in particular seem to be a problem in the comparability of the results. For example, anxious depression has previously been defined as either a single anxiety disorder, any anxiety disorder, different anxiety disorders, scores on anxiety scales or scores on an anxiety factor of a depression scale [21].…”

The clinical characterization of the adult patient with depression aimed at personalization of management

“…Patients with anxious depression are characterized by higher levels of suicidal ideation, poorer functioning, poorer health-related quality of life, and greater chronicity 68 . Co-occurring anxiety has been reported to be a predictor of a poor response to antidepressant treatment in general 33 or to specific antidepressants 69 , but these findings do not necessarily apply to anxious depression as defined in the DSM-5 and ICD-11, because alternative definitions of this depression subtype show only modest levels of concordance 70 . A self-report questionnaire, the CUDOS-A 71 , has been specifically designed to assess the DSM-5 anxious distress specifier.…”

Anxiety Symptoms in Patients with Major Depressive Disorder: Commentary on Prevalence and Clinical Implications

“…The diagnostic criteria for anxiety and depression have fluctuated over time [ 5 ]. As described above, DSM-5 introduced a number of specifiers for MDD, including ‘anxious distress’ (Fig.…”

“…A key clinical question is whether a patient has MDD with anxiety or an anxiety disorder that has triggered an episode of MDD, and many patients will meet more than one definition of anxiety disorders and/or depression [ 5 ]. Often this distinction is based on asking the patient whether they were experiencing anxiety before they became depressed, but many patients with MDD are not able to accurately answer this question.…”

Effects of Anxious Depression on Antidepressant Treatment Response

“…Therefore, in our study we focused on pharmacotherapeutic effectiveness in high-level anxiety phenotypes. The relevance of anxiety in relation to depression has been a topic of interest for researchers since the 1960s and 1970s, when studies began exploring the heterogeneity of depression [21]. An anxiety factor or anxiety cluster was regularly identified [22,23].…”

“…The different definitions of anxious depression in particular seem to be a problem in the comparability of the results. For example, anxious depression has previously been defined as either a single anxiety disorder, any anxiety disorder, different anxiety disorders, scores on anxiety scales or scores on an anxiety factor of a depression scale [21].…”

The clinical characterization of the adult patient with depression aimed at personalization of management

“…Patients with anxious depression are characterized by higher levels of suicidal ideation, poorer functioning, poorer health-related quality of life, and greater chronicity 68 . Co-occurring anxiety has been reported to be a predictor of a poor response to antidepressant treatment in general 33 or to specific antidepressants 69 , but these findings do not necessarily apply to anxious depression as defined in the DSM-5 and ICD-11, because alternative definitions of this depression subtype show only modest levels of concordance 70 . A self-report questionnaire, the CUDOS-A 71 , has been specifically designed to assess the DSM-5 anxious distress specifier.…”

Anxiety Symptoms in Patients with Major Depressive Disorder: Commentary on Prevalence and Clinical Implications

“…The diagnostic criteria for anxiety and depression have fluctuated over time [ 5 ]. As described above, DSM-5 introduced a number of specifiers for MDD, including ‘anxious distress’ (Fig.…”

“…A key clinical question is whether a patient has MDD with anxiety or an anxiety disorder that has triggered an episode of MDD, and many patients will meet more than one definition of anxiety disorders and/or depression [ 5 ]. Often this distinction is based on asking the patient whether they were experiencing anxiety before they became depressed, but many patients with MDD are not able to accurately answer this question.…”

Effects of Anxious Depression on Antidepressant Treatment Response

“…Therefore, in our study we focused on pharmacotherapeutic effectiveness in high-level anxiety phenotypes. The relevance of anxiety in relation to depression has been a topic of interest for researchers since the 1960s and 1970s, when studies began exploring the heterogeneity of depression [21]. An anxiety factor or anxiety cluster was regularly identified [22,23].…”

“…The different definitions of anxious depression in particular seem to be a problem in the comparability of the results. For example, anxious depression has previously been defined as either a single anxiety disorder, any anxiety disorder, different anxiety disorders, scores on anxiety scales or scores on an anxiety factor of a depression scale [21].…”

The clinical characterization of the adult patient with depression aimed at personalization of management

“…Patients with anxious depression are characterized by higher levels of suicidal ideation, poorer functioning, poorer health-related quality of life, and greater chronicity 68 . Co-occurring anxiety has been reported to be a predictor of a poor response to antidepressant treatment in general 33 or to specific antidepressants 69 , but these findings do not necessarily apply to anxious depression as defined in the DSM-5 and ICD-11, because alternative definitions of this depression subtype show only modest levels of concordance 70 . A self-report questionnaire, the CUDOS-A 71 , has been specifically designed to assess the DSM-5 anxious distress specifier.…”

Anxiety Symptoms in Patients with Major Depressive Disorder: Commentary on Prevalence and Clinical Implications

“…The diagnostic criteria for anxiety and depression have fluctuated over time [ 5 ]. As described above, DSM-5 introduced a number of specifiers for MDD, including ‘anxious distress’ (Fig.…”

“…A key clinical question is whether a patient has MDD with anxiety or an anxiety disorder that has triggered an episode of MDD, and many patients will meet more than one definition of anxiety disorders and/or depression [ 5 ]. Often this distinction is based on asking the patient whether they were experiencing anxiety before they became depressed, but many patients with MDD are not able to accurately answer this question.…”