What biomarkers (if any) for precise medicine?

Strano, Sabrina; Muti, Paola; Blandino, Giovanni

doi:10.18632/aging.100798

Cited by 4 publications

(3 citation statements)

References 8 publications

(8 reference statements)

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“…Similarly, potential lncRNA biomarkers for HNCs have been identified [135,136]. Considering the stability, tissue-specificity and abundance of circRNAs [39,129], these molecules are ideal potential biomarkers for precise treatment [40] of HNCs (Table 3). CircPVT1 was upregulated in HNSCC tissues compared to matched normal tissues [137].…”

Section: Circrnas As Biomarkers In Hncsmentioning

confidence: 99%

“…Meanwhile, knowledge regarding the functions and mechanisms of circRNAs in HNCs has been accumulated. Elucidation of the characteristics and functions of circRNAs at the genetic and molecular levels is urgently needed for the development of novel therapies and precision medicines for HNCs [40]. In this paper, we discuss the research advances in circRNAs and summarize the roles of circRNAs and their likely clinical application value in HNCs.…”

Section: Introductionmentioning

confidence: 99%

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Circular RNAs and their roles in head and neck cancers

et al. 2019

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Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has been expanded, and circular RNAs were shown to be key regulators of various diseases, especially cancers. Head and neck cancers are the sixth most popular cancers worldwide, and the overall survival rates remain unsatisfactory. Recent studies have indicated that circular RNAs are involved in the tumorigenesis, progression, invasion and chemosensitivity of head and neck cancers and that some circular RNAs could serve as diagnostic and prognostic biomarkers. In this study, we summarize research advances in the regulation of circular RNA biogenesis, their characteristics and functions, the involvement of circular RNAs in the pathophysiology of head and neck cancers and their potential clinical utilization, as well as the likely directions of future studies.

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Section: Circrnas As Biomarkers In Hncsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circular RNAs and their roles in head and neck cancers

et al. 2019

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“…A relevant feature of miRNAs is their remarkable stability, which indicates their use as biomarkers in a number of different tissues (21,22). In this study, we evaluated the miRNA expression profile of leukocytes derived from buffy coats collected at recruitment.…”

Section: Biomarker Stability and Blood Collectionmentioning

confidence: 99%

MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: the hOrmone and Diet in the ETiology of breast cancer prospective study

Muti

Donzelli²,

Sacconi³

et al. 2017

Carcinogenesis

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MicroRNAs (miRNAs) might be considered both predictors and players of cancer development. The aim of the present report was to investigate whether many years before the diagnosis of breast cancer miRNA expression is already disregulated. In order to test this hypothesis, we compared miRNAs extracted from leukocytes in healthy women who later developed breast cancer and in women who remain healthy during the whole 15-year follow-up time. Accordantly, we used a case-control study design nested in the hOrmone and Diet in the ETiology of breast cancer (ORDET) prospective cohort study addressing the possibility that miRNAs can serve as both early biomarkers and components of the hormonal etiological pathways leading to breast cancer development in premenopausal women. We compared leukocyte miRNA profiles of 191 incident premenopausal breast cancer cases and profiles of 191 women who remained healthy over a follow-up period of 20 years. The analysis identified 20 differentially expressed miRNAs in women candidate to develop breast cancer versus control women. The upregulated miRNAs, miR-513-a-5p, miR-513b-5p and miR-513c-5p were among the most significantly deregulated miRNAs. In multivariate analysis, miR-513a-5p upregulation was directly and statistically significant associated with breast cancer risk (OR = 1.69; 95% CI 1.08-2.64; P = 0.0293). In addition, the upregulation of miR-513-a-5p displayed the strongest direct association with serum progesterone and testosterone levels. The experimental data corroborated the inhibitory function of miR-513a-5p on progesterone receptor expression confirming that progesterone receptor is a target of miR-513a-5p. The identification of upregulated miR-513a-5p with its oncogenic potential further validates the use of miRNAs as long-term biomarker of breast cancer risk.

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What biomarkers (if any) for precise medicine?

Cited by 4 publications

References 8 publications

Circular RNAs and their roles in head and neck cancers

Circular RNAs and their roles in head and neck cancers

MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: the hOrmone and Diet in the ETiology of breast cancer prospective study

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