What are the roles of microRNAs at the mammalian synapse?

Konecna, Anetta; Heraud, Jacki; Schoderboeck, Lucia; Raposo, Alexandre A.S.F.; Kiebler, Michael

doi:10.1016/j.neulet.2009.06.050

Cited by 24 publications

(20 citation statements)

References 46 publications

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“…It is increasingly evident that miRNAs post-transcriptionally regulate localized mRNAs (Konecna et al, 2009) and that some of the effects of BDNF in the central nervous system are mediated through alteration of their expression and/or activity ( Table 1). The BDNF-induced synthesis of LIM domain kinase 1 (LIMK1) in dendrites through local relief of the activity of miR-134 in translation repression was the first demonstration that the synaptic effects of the neurotrophin could be mediated by regulation of miRNAs (Schratt et al, 2006).…”

Section: Mirnas As Mediators Of Bdnf-induced Alteration In the Proteomementioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

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a b s t r a c tBrain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to the activation of the Ras/ERK, phosphatidylinositol 3-kinase/Akt and phospholipase C-g (PLC-g) pathways. The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre-and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of mRNAs along dendrites and their translation at the synapse, by modulating the initiation and elongation phases of protein synthesis, and by acting on specific miRNAs. Furthermore, the effect of BDNF on transcription regulation may further contribute to long-term changes in the synaptic proteome. In this review we discuss the recent progress in understanding the mechanisms contributing to the short-and long-term regulation of the synaptic proteome by BDNF, and the role in synaptic plasticity, which is likely to influence learning and memory formation.This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.

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Section: Mirnas As Mediators Of Bdnf-induced Alteration In the Proteomementioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

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“…Indeed, there is a bidirectional relationship between the two: ncRNAs mediate synaptic processes, and synaptic activity influences ncRNA expression, intracellular transport and function 62,96,100 (FIG. 4).…”

Section: Neural Development Maintenance and Plasticitymentioning

confidence: 99%

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

2012

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Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture, regulation and transcriptional output, as well as by innovations in sequencing technologies and computational and systems biology. These ncRNAs can interact with DNA, RNA and protein molecules; engage in diverse structural, functional and regulatory activities; and have roles in nuclear organization and transcriptional, post-transcriptional and epigenetic processes. This expanding inventory of ncRNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.

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“…Many miRNAs not only show differential neuroanatomical expression [(Bak et al, 2008; Davis et al, 2007; Landgraf et al, 2007; Olsen et al, 2009)], but also display sub-cellular compartmentalization near the synapse [(Konecna et al, 2009), (Schratt, 2009)]. Several miRNAs have been found either enriched or depleted in laser-excised dendrites [(Kye et al, 2007)] and in synaptoneurosomal preparations [(Siegel et al, 2009)], with some pre-miRNAs enriched in the post-synaptic densities [(Lugli et al, 2008)].…”

Section: Introductionmentioning

confidence: 99%

Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation

et al. 2012

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In recent years, microRNAs or miRNAs have been proposed to target neuronal mRNAs localized near the synapse, exerting a pivotal role in modulating local protein synthesis, and presumably affecting adaptive mechanisms such as synaptic plasticity. In the present study we have characterized the distribution of miRNAs in five regions of the adult mammalian brain and compared the relative abundance between total fractions and purified synaptoneurosomes (SN), using three different methodologies. The results show selective enrichment or depletion of some miRNAs when comparing total versus SN fractions. These miRNAs were different for each brain region explored. Changes in distribution could not be attributed to simple diffusion or to a targeting sequence inside the miRNAs. In silico analysis suggest that the differences in distribution may be related to the preferential concentration of synaptically localized mRNA targeted by the miRNAs. These results favor a model of co-transport of the miRNA-mRNA complex to the synapse, although further studies are required to validate this hypothesis. Using an in vivo model for increasing excitatory activity in the cortex and the hippocampus indicates that the distribution of some miRNAs can be modulated by enhanced neuronal (epileptogenic) activity. All these results demonstrate the dynamic modulation in the local distribution of miRNAs from the adult brain, which may play key roles in controlling localized protein synthesis at the synapse.

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What are the roles of microRNAs at the mammalian synapse?

Cited by 24 publications

References 46 publications

BDNF-induced local protein synthesis and synaptic plasticity

BDNF-induced local protein synthesis and synaptic plasticity

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation

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