What are the clues for an inherited metabolic disorder in Reye syndrome? A single Centre study of 58 children

Goetz, Violette; Yang, David Dawei; Lacaille, Florence; Pelosi, Michele; Angoulvant, François; Brassier, Anaïs; Arnoux, Jean‐Baptiste; Schiff, Manuel; Heilbronner, Claire; Salvador, E.; Debray, Dominique; Oualha, Mehdi; Renolleau, Sylvain; Girard, M; Lonlay, Pascale de

doi:10.1016/j.ymgme.2022.02.001

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Reye’s syndrome peaked in the late 1970s, early 1980s and is now quite rare 64. It is best viewed as multifactorial, including viruses, however some cases also had an underlying IMD, mainly UCD or fatty acid disorder of oxidation 65…”

Section: Other Medicationsmentioning

confidence: 99%

Drug-induced hyperammonaemia

Shakerdi

Ryan

2023

J Clin Pathol

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Hyperammonaemia (HA) as a consequence of numerous primary or secondary causes, gives rise to clinical manifestations due to its toxic effects on the brain. The neurological consequences broadly reflect the ammonia level, duration and age, with paediatric patients being more susceptible. Drug-induced HA may arise due to either decreased ammonia elimination or increased production. This is associated most frequently with use of valproate and presents a dilemma between ongoing therapeutic need, toxicity and the possibility of an alternative cause. As there is no specific test for drug-induced HA, prompt discussion with a metabolic physician is recommended, as the neurotoxic effects are time-dependent. Specific guidelines for managing drug-induced HA have yet to be published and hence the treatment approach outlined in this review reflects that outlined in relevant urea cycle disorder guidelines.

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Section: Other Medicationsmentioning

confidence: 99%

Drug-induced hyperammonaemia

Shakerdi

Ryan

2023

J Clin Pathol

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Recognizing and Managing a Metabolic Crisis

Baker

2023

Pediatric Clinics of North America

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Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health

Aragão,

Pires,

Santos-Buelga

et al. 2024

Foods

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Since the early twentieth century, research on vitamins has revealed their therapeutic potential beyond their role as essential micronutrients. Riboflavin, known as vitamin B2, stands out for its unique characteristics. Despite numerous studies, riboflavin remains vital, with implications for human health. Abundantly present in various foods, riboflavin acts as a coenzyme in numerous enzymatic reactions crucial for human metabolism. Its role in energy production, erythrocyte synthesis, and vitamin metabolism underscores its importance in maintaining homeostasis. The impact of riboflavin extends to neurological function, skin health, and cardiovascular well-being, with adequate levels linked to reduced risks of various ailments. However, inadequate intake or physiological stress can lead to deficiency, a condition that poses serious health risks, including severe complications. This underscores the importance of maintaining sufficient levels of riboflavin for general wellness. The essential role of riboflavin in immune function further emphasises its significance for human health and vitality. This paper examines the diverse effects of riboflavin on health and stresses the importance of maintaining sufficient levels for overall well-being.

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What are the clues for an inherited metabolic disorder in Reye syndrome? A single Centre study of 58 children

Cited by 3 publications

References 36 publications

Drug-induced hyperammonaemia

Drug-induced hyperammonaemia

Recognizing and Managing a Metabolic Crisis

Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health

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