2019
DOI: 10.1001/amajethics.2019.988
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What Are Good Guidelines for Evaluating Uterus Transplantation?

Abstract: Recent advances in uterus transplantation (UTx) suggest it is on a trajectory toward becoming an accepted clinical practice to treat absolute uterine factor infertility (AUFI). Additional uses have been envisioned but not studied. UTx programs thus far have relied largely on ethical frameworks associated with clinical research, surgical innovation, organ transplantation, and assisted reproductive technologies, as reflected in the Revised Montreal Criteria and the Indianapolis Consensus. This article argues tha… Show more

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Cited by 9 publications
(4 citation statements)
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“…Moreover, restoration of blood flow and reoxygenation itself paradoxically further enhance the activation of innate and adaptive immune responses and cell death programs (reperfusion injury) [10]. These processes increase the likelihood of short-and long-term complications, such as delayed graft function and acute or chronic rejection [11]. Different strategies to reduce IRI, such as optimization of organ perfusion and storing conditions, or the development of drugs targeting IRI, are under investigation [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, restoration of blood flow and reoxygenation itself paradoxically further enhance the activation of innate and adaptive immune responses and cell death programs (reperfusion injury) [10]. These processes increase the likelihood of short-and long-term complications, such as delayed graft function and acute or chronic rejection [11]. Different strategies to reduce IRI, such as optimization of organ perfusion and storing conditions, or the development of drugs targeting IRI, are under investigation [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…Second, UTx possesses elements of both transplantation medicine and ART. Existing ethical frameworks developed specifically for transplantation medicine or ART, therefore, do not straightforwardly map onto the ethics of UTx ( Horvat and Iltis, 2019 ). Third, the prospect of UTx underscores the potential moral or social significance not only of genetic parenthood, but also of gestational parenthood.…”
Section: Ethics Of Uterus Transplantationmentioning
confidence: 99%
“…The position of UTx as a blend of both transplantation medicine and ART is apparent in some criteria. For example, these criteria require that a recipient ‘does not exhibit frank unsuitability for motherhood’, drawing inspiration from ART ethical frameworks ( Lefkowitz et al , 2012 ; Horvat and Iltis, 2019 ). More generally, there is widespread agreement that the physical, psychological, and broader societal risks of UTx ought to be carefully identified and assessed ( O’Donovan et al , 2019 ).…”
Section: Ethics Of Uterus Transplantationmentioning
confidence: 99%
“…Current ethical frameworks for UTx are based largely on existing guidelines for solid organ transplantation [ 4 ]. However, UTx differs from other forms of organ transplantation in several important respects.…”
Section: Why Uterine Transplantation Poses Ethical Challengesmentioning
confidence: 99%