Wet versus Dry Age-Related Macular Degeneration in Patients with Central Field Loss: Different Effects on Maximum Reading Speed

Calabrèse, Aurélie; Bernard, Jean Baptiste; Hoffart, L.; Faure, Géraldine; Barouch, Fatiha; Conrath, J.; Castet, Éric

doi:10.1167/iovs.09-5056

Cited by 56 publications

(49 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12,14,17,18,26 Another study 30 using MP1 microperimetry in patients with wet or dry AMD found that PRL eccentricity was a predictor of RS. The authors argued that the PRL used by patients during a fixation task is also preferentially used during a reading task or is used at least in some critical periods of the reading process.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Microperimetric Predictors of Reading Speed in Low Vision Patients: A Structural Equation Modeling Approach

Giacomelli

Virgili

Giansanti

et al. 2013

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Clinical and Microperimetric Predictors of Reading Speed in Low Vision Patients: A Structural Equation Modeling Approach

Giacomelli

Virgili

Giansanti

et al. 2013

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

“…15 Therefore, retinal sensitivity assessed by fundus-related microperimetry may provide more reliable insight into macular function deficiencies than by distance VA or reading performance. Accurate measurement of functional deficiency and determination of the responsible morphological correlate enable a better understanding of AMD by detecting the underlying cause of vision loss, which allows a precise determination of the functional stage and may improve the chance of treatment success.…”

mentioning

confidence: 99%

Correlation of SD-OCT Features and Retinal Sensitivity in Neovascular Age-Related Macular Degeneration

Sulzbacher

Kiss

Kaider

et al. 2012

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To correlate retinal sensitivity in patients with neovascular age-related macular degeneration (AMD) with specific characteristics of retinal morphology.METHODS. Thirty eyes of 30 patients presenting with active choroidal neovascularization were examined by spectral domain optical coherence tomography (SD-OCT) and microperimetry (MP-1). Image-processing software was used to match a fundus photographic (FP) MP-1 image with an infraredþOCT SD-OCT image. Each MP test point for retinal sensitivity was positioned at the corresponding SD-OCT location, and the microperimetric results were evaluated.RESULTS. An intact retinal configuration was associated with a median retinal sensitivity of 15.5 dB (quartiles: 12 dB, 18 dB). The median retinal sensitivities were 0 dB (quartiles: 0 dB, 1 dB) for the neovascular complex, 4 dB (0 dB, 9 dB) for the subretinal fluid, 1 dB (0 dB, 6 dB) for the intraretinal fluid, and 0 dB (0 dB, 3 dB) for intraretinal cysts. Pigment epithelium detachment was associated with a median retinal sensitivity of 3 dB (0 dB, 8 dB), and subretinal drusen had a median value of 8 dB (5 dB, 12 dB). Deep retinal layer analyses gave low median retinal sensitivities of 0 dB (0 dB, 3 dB) for an absent retinal pigment epithelium layer and 1 dB (0 dB, 5 dB) for an absent photoreceptor layer.CONCLUSIONS. Superimposition of morphological SD-OCT features and microperimetric retinal sensitivity allowed exact determination of the differential impact of retinal alteration on the corresponding sensitivity. Individual OCT-related indicators of neurosensory integrity were distinctly correlated with visual function. ''Morphofunctional'' findings could be relevant as prognostic factors and for (re)treatment decisions. (https:// www.clinicaltrialsregister.eu/ number, 2006-005684-26.) (Invest Ophthalmol Vis Sci. 2012;53:6448-6455)

show abstract

“…The prevention of oxidative stress at early stages of the disease is therefore considered a potential approach to limiting the severity of AMD. Choroidal neovascularization is responsible for the loss of vision in neovascular AMD [20]. In this process, choroidal capillaries penetrate Bruch's membrane and the RPE.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress regulates expression of claudin-1 in human RPE cells

Hirata

Mochizuki

et al. 2014

Open Life Sciences

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is a neurodegenerative disease associated with irreversible loss of central vision in the elderly. Disruption of the homeostatic function of the retinal pigment epithelium (RPE) is thought to be fundamental to AMD pathogenesis, and oxidative stress is implicated in the associated RPE damage. We examined the effects of oxidative stress on the expression of junctional proteins in cultured human retinal pigment epithelial (ARPE-19) cells. Reverse transcription-PCR and immunoblot analyses revealed that expression of the tight-junction protein claudin-1 was increased at both the mRNA and protein levels 8 to 12 h after exposure of ARPE-19 cells to H2O2, whereas that of the tight-junction protein ZO-1 or the adherens-junction protein N-cadherin was unaffected. Expression of both claudin-1 and N-cadherin was down-regulated by exposure of the cells to H2O2 for longer periods (24 to 48 h). Oxidative stress also induced the phosphorylation of p38 mitogen-activated protein kinase (MAPK) with a time course similar to that apparent for the up-regulation of claudin-1 expression. Furthermore, the increase in the abundance of claudin-1 induced by H2O2 was blocked by the p38 inhibitor SB203580. Phosphorylation of the MAPKs ERK and JNK was not affected by H2O2. Our results suggest that modulation of claudin-1 expression in the RPE by oxidative stress may contribute to the pathogenesis of AMD.

show abstract

Wet versus Dry Age-Related Macular Degeneration in Patients with Central Field Loss: Different Effects on Maximum Reading Speed

Abstract: The four effects improve the ability to predict MRS reliably for AMD patients. The wet/dry difference is a major finding that may result from the different time courses of the two types of disease, thus involving different types of visuomotor and attentional adaptation processes.

Cited by 56 publications

References 45 publications

Clinical and Microperimetric Predictors of Reading Speed in Low Vision Patients: A Structural Equation Modeling Approach

Clinical and Microperimetric Predictors of Reading Speed in Low Vision Patients: A Structural Equation Modeling Approach

Correlation of SD-OCT Features and Retinal Sensitivity in Neovascular Age-Related Macular Degeneration

Oxidative stress regulates expression of claudin-1 in human RPE cells

Contact Info

Product

Resources

About