West Nile virus circulation in south-eastern Romania, 2011 to 2013

Dinu, Sorin; Cotar, Ani Ioana; Pănculescu-Gătej, Ioana R.; Fălcuță, Elena; Prioteasa, Florian Liviu; Sîrbu, Anca; Oprişan, Gabriela; Bădescu, Daniela; Reiter, Paul L.; Ceianu, Cornelia Svetlana

doi:10.2807/1560-7917.es2015.20.20.21130

Cited by 30 publications

(35 citation statements)

References 45 publications

(57 reference statements)

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“…In 2016, the number of cases increased to 93 with some clustering of disease in the eastern part of the country. Molecular investigations revealed that the viruses involved in cases of 2010 and later years (2011-2013) were related to the Volgograd 2007 strain [29][30][31]. Similar to what seems to have happened in Russia; cases between 2014 and 2016 are likely to have been caused by the overwintering of the strain that was detected in Romania in previous years.…”

Section: Flaviviruses (Genus Flavivirus Family Flaviviridae)mentioning

confidence: 82%

West Nile virus and other mosquito-borne viruses present in Eastern Europe

Napp

Petrić

Busquets

2018

Pathogens and Global Health

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Eastern Europe (EE) has been severely affected by mosquito-borne viruses (moboviruses). In this review, we summarize the epidemiology of moboviruses, with particular attention to West Nile virus (WNV). The study of WNV human cases in EE between 2010 and 2016, revealed that the epidemiology of WNV in EE is complex with the combination of introduction of different WNV strains from lineages 1 and 2, and the establishment of endemic cycles. We found a positive correlation between the risk of WNV re-emergence in an area and the number of human cases reported in the previous year. We also report the main ecological and biological characteristics of the key mosquito species vectors of moboviruses. Recent expansion of invasive mosquito species in EE, mainly Aedes albopictus but also Aedes aegypti and Culex quinquefasciatus, may result in new scenarios with an increased risk of transmission of moboviruses. Main gaps of knowledge in relation to moboviruses and their vectors in EE are identified. Understanding the epidemiology of moboviruses in EE is essential for the improvement of their surveillance and the control of the diseases they cause.

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Section: Flaviviruses (Genus Flavivirus Family Flaviviridae)mentioning

confidence: 82%

West Nile virus and other mosquito-borne viruses present in Eastern Europe

Napp

Petrić

Busquets

2018

Pathogens and Global Health

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“…Although several other collected mosquito species (e.g., An. hyrcanus) have been found positive for WNV-RNA in Romania [11,13,24], members of the Culex pipiens complex are considered the main vectors for WNV in both urban and rural/natural transmission cycles [13].…”

Section: Discussionmentioning

confidence: 99%

“…Various outbreaks of WNV infections have been reported in southern and southeastern Europe, resulting in several thousand human cases with dozens of fatal outcomes [8,9]. Thereby, Romania is a hotspot for WNV circulation [6,8,[10][11][12][13][14]. Over the last two decades, the country has experienced at least three large outbreaks of WNV (1996,2010,2018) with a mortality rate of up to 20%.…”

Section: Introductionmentioning

confidence: 99%

Ecology of West Nile Virus in the Danube Delta, Romania: Phylogeography, Xenosurveillance and Mosquito Host-Feeding Patterns

Tomazatos

Jansen

Pfister

et al. 2019

Viruses

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The ecology of West Nile virus (WNV) in the Danube Delta Biosphere Reserve (Romania) was investigated by combining studies on the virus genetics, phylogeography, xenosurveillance and host-feeding patterns of mosquitoes. Between 2014 and 2016, 655,667 unfed and 3842 engorged mosquito females were collected from four sampling sites. Blood-fed mosquitoes were negative for WNV-RNA, but two pools of unfed Culex pipiens s.l./torrentium collected in 2014 were tested positive. Our results suggest that Romania experienced at least two separate WNV lineage 2 introductions: from Africa into Danube Delta and from Greece into south-eastern Romania in the 1990s and early 2000s, respectively. The genetic diversity of WNV in Romania is primarily shaped by in situ evolution. WNV-specific antibodies were detected for 19 blood-meals from dogs and horses, but not from birds or humans. The hosts of mosquitoes were dominated by non-human mammals (19 species), followed by human and birds (23 species). Thereby, the catholic host-feeding pattern of Culex pipiens s.l./torrentium with a relatively high proportion of birds indicates the species’ importance as a potential bridge vector. The low virus prevalence in combination with WNV-specific antibodies indicate continuous, but low activity of WNV in the Danube Delta during the study period.

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“…In Europe, until 2004, when the lineage 2 strain was isolated for the first time in Hungary, only lineage 1 strains were circulating. Since then, lineage 2 strains have been isolated in humans and animals in several countries (Kutasi et al, 2011;Hernández-Triana et al, 2014, Barzon et al, 2015, Dinu et al, 2015, being already responsible for dozens of human deaths.…”

Section: Introductionmentioning

confidence: 99%

West Nile Virus Serosurveillance in Wild Boars from the East of Romania

Paslaru¹,

Porea²,

Savuța³

et al. 2016

BUASVMCN-VM

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West Nile Virus (WNV) is the etiological agent of the WN fever/encephalitis, a re-emerging zoonosis signalled frequently in the last decades in the whole world. The virus can cause severe neurological disease in horses and humans but in many other species specific WNV seroconversion is signalled and may be an useful epidemiological tool. Wild animals can be vectors for many pathogens but the surveillance is limited due to the particularities of those populations. A preliminary serosurvey study was made to evaluate the circulation of WNV in wild boar population from two counties in the south east of Romania. Antibodies against WNV were detected by a competitive ELISA in 43 (63.24% ) of the 68 tested samples (Buzău County 53.33% and Galaţi County 71.05%).This is the first attempt to assess the seroconversion of WNV in wild boars in Romania and we can assume that the infection is maintained in tested areas in a sylvatic enzootic transmission circle. Our previous studies had revealed the high seroprevalence of WNV in horses and domestic birds from the studied areas. Moreover, WN encephalitis was diagnosed in humans from Galaţi and Buzău counties. Our results might bring in light the hypothesis of WNV seroconversion in wild boars and point to further studies. Taking in account that WNV is a Flavivirus of the Japanese encephalitis virus antigenic complex, there is a great possibility to cross react with other related viruses infecting the wildboar, so more specific tests are needed in order to confirm our preliminary results.

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West Nile virus circulation in south-eastern Romania, 2011 to 2013

Cited by 30 publications

References 45 publications

West Nile virus and other mosquito-borne viruses present in Eastern Europe

West Nile virus and other mosquito-borne viruses present in Eastern Europe

Ecology of West Nile Virus in the Danube Delta, Romania: Phylogeography, Xenosurveillance and Mosquito Host-Feeding Patterns

West Nile Virus Serosurveillance in Wild Boars from the East of Romania

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