Wernicke-Korsakoff syndrome of nonalcoholic origin

Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy

“…Preservation of executive functions may help patients partially adjust to the memory impairment and lead to underdiagnosis of non-alcoholic KS. Remote memory impairment has been previously documented neuropsychologically in two non-alcoholic KS patients [13,14], whereas in one case impairment receded during follow-up [12] and in another improved [17]. We did not test remote memory.…”

“…In all five previously reported cases of neuropsychologically documented non-alcoholic KS also studied with MRI, there were no atrophy findings [12,13,15,17,19]. However, MB atrophy [32][33][34], thalamic atrophy [35], and vermis atrophy [36] have been reported in studies that mention memory impairment after non-alcoholic WE.…”

“…In all nine previously reported cases of non-alcoholic KS where delayed memory was tested, it was found impaired [12][13][14][15][16][17][18][19]. Immediate memory was impaired in five of eight tested cases [13][14][15][16]20], in one case it was reported as unaffected but test results appear to indicate impairment [19], in one case impairment receded during follow-up [12], and in one case immediate memory was normal [17]. Recognition was impaired in all three tested cases [12,14,19].…”

Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy

“…Preservation of executive functions may help patients partially adjust to the memory impairment and lead to underdiagnosis of non-alcoholic KS. Remote memory impairment has been previously documented neuropsychologically in two non-alcoholic KS patients [13,14], whereas in one case impairment receded during follow-up [12] and in another improved [17]. We did not test remote memory.…”

“…In all five previously reported cases of neuropsychologically documented non-alcoholic KS also studied with MRI, there were no atrophy findings [12,13,15,17,19]. However, MB atrophy [32][33][34], thalamic atrophy [35], and vermis atrophy [36] have been reported in studies that mention memory impairment after non-alcoholic WE.…”

“…In all nine previously reported cases of non-alcoholic KS where delayed memory was tested, it was found impaired [12][13][14][15][16][17][18][19]. Immediate memory was impaired in five of eight tested cases [13][14][15][16]20], in one case it was reported as unaffected but test results appear to indicate impairment [19], in one case impairment receded during follow-up [12], and in one case immediate memory was normal [17]. Recognition was impaired in all three tested cases [12,14,19].…”

Functional Neuroimaging of Cortical Dysfunction in Alcoholic Korsakoff's Syndrome

“…Motor disorders of alcoholic cerebellar degeneration can occur either along with Korsakoff s syndrome or independently and probably derive from the same disease process (Victor et al, 1989). Korsakoff s syndrome has been observed in nonalcoholic, nutritionally compromised patients (e.g., Beatty, Bailly, & Fisher, 1988; Becker et al, 1990; Parkin et al, 1991), and although some of this evidence is equivocal, the earlier literature attests to the contribution of nonalcoholic causes (Kopelman, 1995). Therefore, alcoholism is not a necessary forerunner of Korsakoff s syndrome.…”

Thiamine deficiency related peripheral neuropathy in peripartum women of Kashmir, India: a hospital based study

“…Thiamine deficiency disorders TDD are most often associated with chronic alcoholism, malabsorption, poor dietary intake, increased metabolic requirement (e.g., during systemic illnesses), anorexia nervosa or dieting, hyperemesis of pregnancy, prolonged intravenous feeding without proper supplementation, prolonged fasting or starvation, or unbalanced nutrition, gastrointestinal surgery (including bariatric surgery), genetic disorder of thiamine metabolism. 20,21 A number of studies have shown relationship between pregnancy and thiamine deficiency. In a study on Karen displaced population in Thailand 6 out of 18 pregnant females were deficient biochemically in thiamine at term.…”

Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy

“…Preservation of executive functions may help patients partially adjust to the memory impairment and lead to underdiagnosis of non-alcoholic KS. Remote memory impairment has been previously documented neuropsychologically in two non-alcoholic KS patients [13,14], whereas in one case impairment receded during follow-up [12] and in another improved [17]. We did not test remote memory.…”

“…In all five previously reported cases of neuropsychologically documented non-alcoholic KS also studied with MRI, there were no atrophy findings [12,13,15,17,19]. However, MB atrophy [32][33][34], thalamic atrophy [35], and vermis atrophy [36] have been reported in studies that mention memory impairment after non-alcoholic WE.…”

“…In all nine previously reported cases of non-alcoholic KS where delayed memory was tested, it was found impaired [12][13][14][15][16][17][18][19]. Immediate memory was impaired in five of eight tested cases [13][14][15][16]20], in one case it was reported as unaffected but test results appear to indicate impairment [19], in one case impairment receded during follow-up [12], and in one case immediate memory was normal [17]. Recognition was impaired in all three tested cases [12,14,19].…”

Functional Neuroimaging of Cortical Dysfunction in Alcoholic Korsakoff's Syndrome

“…Motor disorders of alcoholic cerebellar degeneration can occur either along with Korsakoff s syndrome or independently and probably derive from the same disease process (Victor et al, 1989). Korsakoff s syndrome has been observed in nonalcoholic, nutritionally compromised patients (e.g., Beatty, Bailly, & Fisher, 1988; Becker et al, 1990; Parkin et al, 1991), and although some of this evidence is equivocal, the earlier literature attests to the contribution of nonalcoholic causes (Kopelman, 1995). Therefore, alcoholism is not a necessary forerunner of Korsakoff s syndrome.…”

Thiamine deficiency related peripheral neuropathy in peripartum women of Kashmir, India: a hospital based study

“…Thiamine deficiency disorders TDD are most often associated with chronic alcoholism, malabsorption, poor dietary intake, increased metabolic requirement (e.g., during systemic illnesses), anorexia nervosa or dieting, hyperemesis of pregnancy, prolonged intravenous feeding without proper supplementation, prolonged fasting or starvation, or unbalanced nutrition, gastrointestinal surgery (including bariatric surgery), genetic disorder of thiamine metabolism. 20,21 A number of studies have shown relationship between pregnancy and thiamine deficiency. In a study on Karen displaced population in Thailand 6 out of 18 pregnant females were deficient biochemically in thiamine at term.…”

Non-alcoholic Korsakoff syndrome in psychiatric patients with a history of undiagnosed Wernicke's encephalopathy

“…Preservation of executive functions may help patients partially adjust to the memory impairment and lead to underdiagnosis of non-alcoholic KS. Remote memory impairment has been previously documented neuropsychologically in two non-alcoholic KS patients [13,14], whereas in one case impairment receded during follow-up [12] and in another improved [17]. We did not test remote memory.…”

“…In all five previously reported cases of neuropsychologically documented non-alcoholic KS also studied with MRI, there were no atrophy findings [12,13,15,17,19]. However, MB atrophy [32][33][34], thalamic atrophy [35], and vermis atrophy [36] have been reported in studies that mention memory impairment after non-alcoholic WE.…”

“…In all nine previously reported cases of non-alcoholic KS where delayed memory was tested, it was found impaired [12][13][14][15][16][17][18][19]. Immediate memory was impaired in five of eight tested cases [13][14][15][16]20], in one case it was reported as unaffected but test results appear to indicate impairment [19], in one case impairment receded during follow-up [12], and in one case immediate memory was normal [17]. Recognition was impaired in all three tested cases [12,14,19].…”

Functional Neuroimaging of Cortical Dysfunction in Alcoholic Korsakoff's Syndrome

“…Motor disorders of alcoholic cerebellar degeneration can occur either along with Korsakoff s syndrome or independently and probably derive from the same disease process (Victor et al, 1989). Korsakoff s syndrome has been observed in nonalcoholic, nutritionally compromised patients (e.g., Beatty, Bailly, & Fisher, 1988; Becker et al, 1990; Parkin et al, 1991), and although some of this evidence is equivocal, the earlier literature attests to the contribution of nonalcoholic causes (Kopelman, 1995). Therefore, alcoholism is not a necessary forerunner of Korsakoff s syndrome.…”

Thiamine deficiency related peripheral neuropathy in peripartum women of Kashmir, India: a hospital based study

“…Thiamine deficiency disorders TDD are most often associated with chronic alcoholism, malabsorption, poor dietary intake, increased metabolic requirement (e.g., during systemic illnesses), anorexia nervosa or dieting, hyperemesis of pregnancy, prolonged intravenous feeding without proper supplementation, prolonged fasting or starvation, or unbalanced nutrition, gastrointestinal surgery (including bariatric surgery), genetic disorder of thiamine metabolism. 20,21 A number of studies have shown relationship between pregnancy and thiamine deficiency. In a study on Karen displaced population in Thailand 6 out of 18 pregnant females were deficient biochemically in thiamine at term.…”