Biochemical Pharmacology volume 79, issue 3, P463-470 2010 DOI: 10.1016/j.bcp.2009.09.002 View full text
Antoine Amaury Lachaud, Sacha Auclair-Vincent, Laurent Massip, Étienne Audet-Walsh, Michel Lebel, Alan Anderson

Abstract: Werner's syndrome (WS) is a rare human autosomal recessive segmental progeroid syndrome clinically characterized by atherosclerosis, cancer, osteoporosis, type 2 diabetes mellitus and ocular cataracts. The WRN gene codes for a RecQ helicase which is present in many tissues. Although the exact functions of the WRN protein remain unclear, accumulating evidence suggests that it participates in DNA repair, replication, recombination and telomere maintenance. It has also been proposed that WRN participates in RNA p…

expand abstract