Well-differentiated thyroid carcinomas: p53 mutation status and microvessel density

Goldenberg, John D.; Portugal, Louis; Wenig, Barry L.; Ferrer, Karen; Wu, James; Sabnani, Jaishiri

doi:10.1002/(sici)1097-0347(199803)20:2<152::aid-hed9>3.0.co;2-1

Cited by 26 publications

(27 citation statements)

References 25 publications

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“…These findings highlight the role played by intratumoural lymphangiogenesis in lymph node metastisation at variance with the controversial importance of intratumoural angiogenesis in the metastatic potential of FTC and PTC [16,18,[28][29][30]. While in CPTC, the most important pathway of initial dissemination appears to be via intratumoural lymph vessels, in encapsulated follicular patterned tumours, the invasion via veins of the capsule or outside the tumour is necessary to predict blood-borne metastasis [3,44].…”

Section: Discussionmentioning

confidence: 98%

“…In the past, the endothelial markers used to identify vessels, like factor VIII, CD31, CD34 and von Willebrand factor, highlighted both lymphatic and blood vessels [18,19,[27][28][29][30]. The situation has changed with the finding of lymphatic vessel specific immunomarkers [31,32], which have been used to determine the intratumoural and the peritumoural LVD in several thyroid tumour types, such as the lymphatic endothelium-specific markers D2-40 (podoplanin) [3,21,33,34], LYVE-1 (lymph vessel endothelial hyaluronan receptor) [16,33,35] and VEGFR-3/flt-4 (VEGF receptor-3) [22,24,25].…”

Section: Introductionmentioning

confidence: 99%

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Intratumoural lymph vessel density is related to presence of lymph node metastases and separates encapsulated from infiltrative papillary thyroid carcinoma

et al. 2011

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Papillary thyroid carcinoma (PTC) gives frequently rise to nodal metastases via lymphatic vessels while follicular thyroid carcinoma (FTC) metastasises mainly via blood vessels to lung and bones. The follicular variant of PTC (FVPTC) encompasses the infiltrative subtype (I-FVPTC), which shares most of the features of classic PTC (CPTC), and the encapsulated subtype (E-FVPTC), which appears to be related to minimally invasive FTC. In an attempt to contribute to the understanding of the aforementioned differences, we evaluated intratumoural and peritumoural lymph vessels density (LVD), using the immunomarker D2-40 in a series of E-FVPTC, I-FVPTC, and CPTC with known BRAF and RAS status. None of the E-FVPTC cases presented extra-thyroid extension, lymph vessel invasion or nodal metastases, at variance with I-FVPTC and CPTC cases. The BRAF V600E mutation was detected in 8.3% of E-FVPTC, 25.0% of I-FVPTC and in 40.7% of CPTC, while N-RAS Q61R mutation was detected only in 10.3% of FVPTC cases. Only one case of E-FVPTC (8.3%) had intratumoural D2-40-stained vessels in contrast to their presence in 76.5% of the cases of I-FVPTC. Intratumoural LVD determined by D2-40 expression correlated with the occurrence of extra-thyroid extension, lymph vessel invasion and lymph node metastases in PTC cases. At variance with intratumoural LVD, peritumoural LVD was not associated with any clinic-pathological or molecular feature, being similar in E-FVPTC, I-FVPTC and CPTC. Our study highlights the role of intratumoural lymph vessels in PTC nodal metastisation and reinforces the importance of distinguishing E-FVPTC from I-FVPTC regarding invasiveness, metastatic pattern and molecular profile.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Intratumoural lymph vessel density is related to presence of lymph node metastases and separates encapsulated from infiltrative papillary thyroid carcinoma

et al. 2011

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“…10 In a more recent study using nine follicular carcinomas and 29 papillary carcinomas, an American group could similarly find no significant relation between vascularity and two prognostic markers-that is, locoregional metastasis and tumour recurrence. 11 In the Italian study, all the three papillary carcinoma patients who died, compared with only two of the five follicular carcinoma patients who died, had tumours with microvessel counts above the median value for the respective tumour type. 10 However, our findings indicate an opposite trend-that is, an association between vascularity and prognosis is suggested among follicular carcinomas but not among papillary carcinomas.…”

Section: Discussionmentioning

confidence: 98%

Measurement of vascularity as a diagnostic and prognostic tool for well differentiated thyroid tumours: comparison of different methods of assessing vascularity.

Wong¹,

Willott²,

Kendall³

et al. 1999

J Clin Pathol

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Aims-Todetermine whether the measurement of vascularity can be used to diVerentiate follicular adenomas from follicular carcinomas or to reflect the prognosis of follicular carcinomas and papillary carcinomas of the thyroid gland, and to compare four methods of assessing vascularity. Methods-Tissue sections from 26 papillary carcinomas, 15 follicular adenomas, and 15 follicular carcinomas were stained with an antibody to CD34. A computerised image analysis system was used to calculate, for each tumour, mean endothelial areas and the mean endothelium to tumour epithelial nucleus area ratio from 10 systematically selected fields across one dimension of the tumour ("systematic field" analysis) or from the three most vascularised fields of the tumour ("hot spot" analysis). A European Organisation for Research on Treatment of Cancer (EORTC) prognostic index was calculated for each papillary carcinoma and follicular carcinoma. Results-Significant diVerences in vascularity between the three tumour groups could only be shown by comparing mean endothelial area values measured from hot spots. While the hot spot median mean endothelial area of follicular carcinomas was significantly greater than that of follicular adenomas, there was a large overlap between the two groups. For follicular carcinomas, higher hot spot mean endothelial area values were related to worse prognosis as indicated by the EORTC prognostic indices. No association between vascularity and prognosis was found for the papillary carcinomas, regardless of the method of assessing vascularity. Conclusions-Measuring endothelial area from hot spots using a computerised image analysis system is a sensitive method of assessing the vascularity of thyroid tumours. While vascularity measurement cannot be recommended as a practical tool for diVerentiating between malignant and benign follicular tumours, the suggestion that vascularity may reflect prognosis for follicular carcinomas deserves further study.(J Clin Pathol 1999;52:593-597)

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“…Therefore, it is not possible to apply the Weidner model to intratumoral microvessel density. In contrast, Goldenberg et al, 38 also using CD-34 as a vessel marker, found significant increases of microvessel counting within tumor tissue compared with surrounding normal thyroid tissue. Contrary to neoplasms in other tissues, such as mammary, prostatic, and pulmonary, we observed a progressive reduction in vascularization from CG to FA, and further in FC, mainly in advanced forms.…”

Section: Discussionmentioning

confidence: 99%

Metalloproteinase-9 immunoexpression and angiogenesis in thyroid follicular neoplasms: Relation to clinical and histopathologic features

Friguglietti

Mello²,

Castro³

et al. 2000

Head Neck

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Well-differentiated thyroid carcinomas: p53 mutation status and microvessel density

Cited by 26 publications

References 25 publications

Intratumoural lymph vessel density is related to presence of lymph node metastases and separates encapsulated from infiltrative papillary thyroid carcinoma

Intratumoural lymph vessel density is related to presence of lymph node metastases and separates encapsulated from infiltrative papillary thyroid carcinoma

Measurement of vascularity as a diagnostic and prognostic tool for well differentiated thyroid tumours: comparison of different methods of assessing vascularity.

Metalloproteinase-9 immunoexpression and angiogenesis in thyroid follicular neoplasms: Relation to clinical and histopathologic features

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