Well-differentiated papillary mesothelioma: A 17-year single institution experience with a series of 75 cases

Sun, Meng; Zhao, Lu; Lao, I Weng; Yu, Lin; Wang, Jian

doi:10.1016/j.anndiagpath.2018.10.012

Cited by 41 publications

(56 citation statements)

References 40 publications

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“…Patients with WDPM are considered to have a tumor of uncertain malignant potential or a tumor with an indolent behavior. The prognosis is relatively good, with no effect on survival in most patients. Only a few patients with resected tumors experience an aggressive course or metastases .…”

Section: Discussionmentioning

confidence: 99%

A giant, well‐differentiated papillary mesothelioma of the left atrioventricular groove: Case report and brief review of the literature

Wang

Ren

Xiao

et al. 2019

J of Clinical Ultrasound

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Of the primary cardiac tumors, well‐differentiated papillary mesothelioma (WDPM) is very rare, with only one case report documenting WDPM of the pericardium. We report herein a 17‐year‐old boy who had an abnormal chest X‐ray on a routine college‐entrance examination. A giant cardiac tumor was detected by echocardiography. The neoplasm was partially resected, and histopathological examination revealed a WDPM. The patient recovered without any complication.

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Section: Discussionmentioning

confidence: 99%

A giant, well‐differentiated papillary mesothelioma of the left atrioventricular groove: Case report and brief review of the literature

Wang

Ren

Xiao

et al. 2019

J of Clinical Ultrasound

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“…This differentiation is made more difficult by an identification that is often ancillary [38,41]. [4,5] 55% positive [24] Mostly positive [23] EMA Positive (focally) 35% positive [5], positive [4,5,7,9,18,19], negative [13] 0% positive, [22,25], 20% positive [26] Usually positive [27] Vimentin Focally positive 100% positive [13,19] Positive [25] Usually positive [28] Cytokeratin CK5/6: negative CK5/6: 92-93% positive [4,5], positive [6 9-11,15,18], negative [7,16] CK5 WDPM is rare and distinct from malignant mesothelioma based on clinicopathology [19,20,38,42]. WDPM most commonly occurs in women, spanning a wide age range, but usually occurs during the reproductive years.…”

Section: Discussionmentioning

confidence: 99%

“…WDPM most commonly occurs in women, spanning a wide age range, but usually occurs during the reproductive years. Primarily arising from the peritoneal surfaces of the abdomen and pelvis, WDPM can also occur in the pleura, pericardium, and tunica vaginalis [5,38,43]. Clinically, it is often discovered incidentally during pelvic examination or surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Imaging features of WDPM are not well documented; however, peritoneal thickening, multiple peritoneal nodules (occasionally calcified), omental infiltration, and ascites have all been reported [44,45]. In contrast to mesothelioma, WDPM is not commonly associated with asbestos exposure [5,38]. The well-formed papillary architecture of WDPM superficially spreads and is lined by single layers of bland, cuboidal, or flattened mesothelial cells with little to no nuclear atypia, usually without mitoses [5,38].…”

Section: Discussionmentioning

confidence: 99%

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Well-Differentiated Papillary Mesothelioma with Omental Calcifications: A Case Report and Review of the Literature

Erem¹,

Allamaneni

Braverman

2020

Am J Case Rep

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Rare co-existance of disease or pathology Background:Omental calcifications of the peritoneum are typically small and asymptomatic. However, larger psammomatous bodies that cause symptoms such as abdominal pain and bloating are often associated with tumors such as primary serous papillary carcinoma, mesothelioma, or metastatic ovarian cancer. Case Report:We describe omental calcifications in a 68-year-old woman who had been asymptomatic for the last 10 years.The case details the histomorphologic features and immunohistochemical signature of a 4.0×3.5×1.0 cm mass consisting of mature adipose tissue that was surgically removed together with an 8.5×6.5×1.8 cm irregular intra-abdominal/mesenteric mass composed of yellow-red fatty tissue. Microscopic sections contained fat with variable clustered classic/psammomatous calcifications, some with a thin epithelioid periphery, in association with a very focal and subtle papillary surface epithelial/mesothelial proliferation. Tumor cell invasion was not observed during examination. Immunohistochemical staining showed that mesothelial cells in the mass were strongly positive for calretinin and focally positive for EMA, CK903, and vimentin. Strong nuclear positivity for PAX8 was also reported. Additional stains were added in response to this pattern, showing strong positivity for CK8, moderate positivity for BAP1, focal positivity for ER, minimal positivity for CD56, and negativity for CK5/6 and D2-40. Three possible explanations are suggested for the phenomenon observed in the pathology slides: reactive mesothelial hyperplasia, well-differentiated papillary mesothelioma, or serous papillary carcinoma of the peritoneum. Conclusions:Findings suggest that these calcifications are a benign, reactive phenomenon, and that the abundance of psammoma bodies may be related to ongoing crops of papillary mesothelial hyperplasia or benign well-differentiated papillary mesothelioma.

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“…However, it is important to keep in mind that PAX8 stains positively in 15 to 20% of MPM samples, making the diagnosis challenging. Additionally, PAX8 staining is highly sensitive and specific for WDPPM [28]. MPM can be subdivided into three histologies: epithelioid, sarcomatoid, and biphasic (or mixed).…”

Section: Clinical Presentation Diagnosis and Stagingmentioning

confidence: 99%

Current Concepts in the Diagnosis and Management of Patients With Malignant Peritoneal Mesothelioma

Ginalis

Patel

et al. 2019

Multidiscip Cancer Investig

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Malignant peritoneal mesothelioma (MPM) is a malignancy that arises from the mesothelial lining of the abdominal cavity and largely manifests as a diffuse process. There are two hallmark features of MPM. First, MPM may progress and present itself diversely among patients. While some patients may endure a quick tumor progression that is refractory to seemingly successful initial therapeutic cytoreductive surgery, other patients many survive several years despite the presence of disease. Second, the disease usually progresses in the abdominal cavity with clinically relevant systemic metastases being rare and therefore patients suffer morbidity and mortality from loco-regional disease progression. When MPM disseminates outside the abdomen, it only occurs in the setting of advanced intra-abdominal disease. The majority of patients present with nonspecific signs and symptoms, which often results in a diagnosis of MPM when the condition is already fairly advanced. As the diagnosis is often made late, patients who are treated with only supportive care have a median survival of less than one year. The combination of systemic cisplatin with pemetrexed has an overall response rate of approximately 25%. However, as primary therapy, these agents have not been shown to meaningfully alter the natural history of the disease. Operative cytoreduction and regional chemotherapy administered as hyperthermic intraoperative peritoneal chemotherapy or early postoperative intraperitoneal chemotherapy has been found to improve survival in appropriately selected patients.

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Well-differentiated papillary mesothelioma: A 17-year single institution experience with a series of 75 cases

Cited by 41 publications

References 40 publications

A giant, well‐differentiated papillary mesothelioma of the left atrioventricular groove: Case report and brief review of the literature

A giant, well‐differentiated papillary mesothelioma of the left atrioventricular groove: Case report and brief review of the literature

Well-Differentiated Papillary Mesothelioma with Omental Calcifications: A Case Report and Review of the Literature

Current Concepts in the Diagnosis and Management of Patients With Malignant Peritoneal Mesothelioma

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