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Abstract: As the Senior Editors of the Journal of Comparative Effectiveness Research (JCER) we are delighted to present you with the first issue of this exciting new publication, focusing on the socially and clinically impactful field of comparative effectiveness research (CER).

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“…Comparative effectiveness research (CER) concerns the direct comparison of existing healthcare interventions, identifying which patient groups will benefit most from a given intervention and which are more liable to harm. The availability of routinely collected healthcare data in Italy offers a unique opportunity for research in the context of CER, comparing the benefits and harms of therapeutic strategies available in routine practice, for the prevention, diagnosis or treatment of a given health condition aiming to determine which treatment works best, for whom, and under what circumstances [74]. CER can be, and is, carried out using common analytic methods applied in observational research based on healthcare databases.…”
Section: Comparative Effectiveness Research and Health Technology Assessmentmentioning
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“…Comparative effectiveness research (CER) concerns the direct comparison of existing healthcare interventions, identifying which patient groups will benefit most from a given intervention and which are more liable to harm. The availability of routinely collected healthcare data in Italy offers a unique opportunity for research in the context of CER, comparing the benefits and harms of therapeutic strategies available in routine practice, for the prevention, diagnosis or treatment of a given health condition aiming to determine which treatment works best, for whom, and under what circumstances [74]. CER can be, and is, carried out using common analytic methods applied in observational research based on healthcare databases.…”
Section: Comparative Effectiveness Research and Health Technology Assessmentmentioning
“…They defined CER as “a strategy that focuses on the practical comparison of two or more health intervention to discern what works best for which patients and populations” ( 1 ). In essence, the goal of CER is to help answer the question “which treatment will work best, in which patient, under what circumstances?” ( 2 ). Big Data refers to data sets that are so large that they cannot be analyzed directly by individuals or traditional processing software.…”
Section: Comparative Effectiveness Research (Cer) and Big Datamentioning
“…[1] Therefore, CER is indispensable to assist consumers, clinicians, purchasers, and policy makers to make evidence-based decisions. Actually, an obvious uprising tendency of CER after 2004 was displayed and a majority of CER was performed by randomized clinical trials (RCTs) with active controlled interventions.…”
Section: What Is the Problem?mentioning
“…Different from trials for regulatory approvals of new interventions aimed to test the efficacy, comparative effectiveness research (CER) is the direct comparison of existing health-care interventions (compared with active controls) to examine which treatment works best, for whom, and under what settings. [ 1 ] Therefore, CER is indispensable to assist consumers, clinicians, purchasers, and policy makers to make evidence-based decisions. Actually, an obvious uprising tendency of CER after 2004 was displayed and a majority of CER was performed by randomized clinical trials (RCTs) with active controlled interventions.…”
Section: W Hat I S the P mentioning