Weissella cibaria EIR/P2-derived exopolysaccharide: A novel alternative to conventional biomaterials targeting periodontal regeneration

Anionic exopolysaccharide from Cryptococcus laurentii 70766 as an alternative for alginate for biomedical hydrogels

“…GUMS16 (a novel cold-adapted yeast), was biocompatible toward human dermal fibroblast (HDF) cell line during 48 h [35]. In addition, the EPS (10 to 1000 μg/mL) from Weissella cibaria EIR/P2 did not have a toxicity effect against human periodontal ligament fibroblast cells (hPDLFCs) during 24 hours and also showed proliferative effect on hPDLFCs [84]. Moreover, Liu et al revealed enhanced biocompatibility and the ability for stimulating wound healing.…”

Periodontal Bifunctional Biomaterials: Progress and Perspectives

“…In vitro experiments showed that they presented antibacterial activity against periodontal pathogens such as Porphyromonas gingivalis (P. gingivalis) and Streptococcus mutans (S. mutans). In addition, they promoted proliferation or osteogenic differentiation of cells responsible for periodontal regeneration, including human periodontal ligament fibroblasts (hPDLFCs), human periodontal ligament cells (hPDLCs) and bone marrow mesenchymal stem cells (BMSCs) [8,11,14,15]. In a mouse periodontitis model, psoralen and angelicin were able to reduce bone loss [14].…”

“…The results demonstrated that BA could generate some benefits, regarding clinical and radiographic indices. Furthermore, some agents could regulate inflammation and immune response, showing antioxidant activity [11,14,15].…”

“…The performance of drug delivery systems is related to type and proportion of the loaded components and surface of the carriers. In these systems, antibacterial components are not only antibiotics [51,54], but also metal nanoparticles such as silver [11,[23][24][25][26][27][28][29][30][31][34][35][36][37][38][39]43,44,46,52,53,57,58] and polymer nanoparticles such as CS (nCS) [53]. Osteogenic components include drugs such as lovastatin and minocycline [51,54], metal nanoparticles such as silver and calcium [52,59], and polymer nanoparticles such as poly(lactic-co-glycolic acid) (nPLGA) and nCS [53], etc.…”

“…Many efforts have been made to improve periodontal treatment outcome. Typical treatment of periodontitis focuses on pathological process and reaches a satisfactory outcome [9][10][11]. However, effectively regenerating periodontal tissues remains a challenge [12].…”