2018
DOI: 10.1038/s41387-018-0042-0
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Abstract: BackgroundUndiagnosed comorbid diseases that independently lead to weight loss before type 2 diabetes mellitus (T2DM) diagnosis could explain the observed increased mortality risk in T2DM patients with normal weight.ObjectivesTo evaluate the impact of weight change patterns before the diagnosis of T2DM on the association between body mass index (BMI) at diagnosis and mortality risk.MethodsThis was a longitudinal cohort study using 145,058 patients from UK primary care, with newly diagnosed T2DM from January 20… Show more

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Cited by 11 publications
(6 citation statements)
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“…It must be considered that the role of BMI measurement alone is inadequate for accurately predict the disease progression in DM subjects [41]. Other parameters such as body composition, total adipose mass, visceral adiposity-accumulation of intra-abdominal fat, and muscle mass should be analyzed to describe the current condition of DM subjects [41][42][43].…”
Section: Discussionmentioning
confidence: 99%
“…It must be considered that the role of BMI measurement alone is inadequate for accurately predict the disease progression in DM subjects [41]. Other parameters such as body composition, total adipose mass, visceral adiposity-accumulation of intra-abdominal fat, and muscle mass should be analyzed to describe the current condition of DM subjects [41][42][43].…”
Section: Discussionmentioning
confidence: 99%
“…Os benefícios da atividade física, seja ela regular ou não, ultrapassam a questão estética e a redução de peso, uma vez que é capaz de diminuir o risco cardiovascular, aumentando o número de capilares e fibras musculares, estimulando e facilitando o transporte e captação de glicose pela membrana plasmática e pelos tecidos, levando à diminuição dos níveis glicêmicos FERNÁNDEZ et al 2018;OWUSU et al, 2018).…”
Section: Discussionunclassified
“…[9][10][11] Cohort studies in newly diagnosed T2D patients also yielded mixed, contrasting ndings of weight loss in relation to mortality. [12][13][14][15] The con icting evidence for this association may be ascribed, at least partially, to heterogeneity in causes, extent, and timeframe of weight change. Both hyperglycemia and hyperinsulinemia exacerbate protein catabolism and muscle oxidative damage, which gradually result in muscle atrophy and weight loss.…”
Section: Introductionmentioning
confidence: 99%