Weight loss and improvement of lipid profiles in morbidly obese patients after laparoscopic one-anastomosis gastric bypass: 2-year follow-up

Carbajo, Miguel Ángel Martín; Fong-Hirales, Arlett; Luque-de-León, Enrique; Molina-López, Juan Francisco; Ortiz‐de‐Solorzano, Javier

doi:10.1007/s00464-016-4990-y

Cited by 38 publications

(19 citation statements)

References 24 publications

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“…Once WL was being achieved, other “mechanical”-related comorbidities were also abated. We recently published results from selected patients included in the IFSO-European Accreditation Council (EAC) for Centers of Excellence database with insulin resistance/type 2 DM [32] or lipid profile derangements [36]. Substantial WL and significant improvement or full remission from their metabolic condition was observed in both series.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic One-Anastomosis Gastric Bypass: Technique, Results, and Long-Term Follow-Up in 1200 Patients

Carbajo¹,

Luque-de-León²,

Jiménez³

et al. 2016

OBES SURG

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296

157

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BackgroundExcellent results have been reported with mini-gastric bypass. We adopted and modified the one-anastomosis gastric bypass (OAGB) concept. Herein is our approach, results, and long-term follow-up (FU).MethodsInitial 1200 patients submitted to laparoscopic OAGB between 2002 and 2008 were analyzed after a 6–12-year FU. Mean age was 43 years (12–74) and body mass index (BMI) 46 kg/m2 (33–86). There were 697 (58 %) without previous or simultaneous abdominal operations, 273 (23 %) with previous, 203 (17 %) with simultaneous, and 27 (2 %) performed as revisions.ResultsMean operating time (min) was as follows: (a) primary procedure, 86 (45–180); (b) with other operations, 112 (95–230); and (c) revisions, 180 (130–240). Intraoperative complications led to 4 (0.3 %) conversions. Complications prompted operations in 16 (1.3 %) and were solved conservatively in 12 (1 %). Long-term complications occurred in 12 (1 %). There were 2 (0.16 %) deaths. Thirty-day and late readmission rates were 0.8 and 1 %. Cumulative FU was 87 and 70 % at 6 and 12 years. The highest mean percent excess weight loss was 88 % (at 2 years), then 77 and 70 %, 6 and 12 years postoperatively. Mean BMI (kg/m2) decreased from 46 to 26.6 and was 28.5 and 29.9 at those time frames. Remission or improvement of comorbidities was achieved in most patients. The quality of life index was satisfactory in all parameters from 6 months onwards.ConclusionsLaparoscopic OAGB is safe and effective. It reduces difficulty, operating time, and early and late complications of Roux-en-Y gastric bypass. Long-term weight loss, resolution of comorbidities, and degree of satisfaction are similar to results obtained with more aggressive and complex techniques. It is currently a robust and powerful alternative in bariatric surgery.

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Section: Discussionmentioning

confidence: 99%

Laparoscopic One-Anastomosis Gastric Bypass: Technique, Results, and Long-Term Follow-Up in 1200 Patients

Carbajo¹,

Luque-de-León²,

Jiménez³

et al. 2016

OBES SURG

Self Cite

296

157

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“…In regard to the safety profile of laparoscopic OAGB, according to the currently available evidence, there are acceptable early and late complication rates, and the frequency of symptomatic bile reflux is lower than firstly feared, although this information mainly relies on self-reporting (7,(24)(25)(26) .…”

Section: Discussionmentioning

confidence: 99%

Early Weight Loss Outcomes and Glucose Metabolism Parameters After Banded Versus Non-Banded One Anastomosis Gastric Bypass: A Prospective Randomized Trial

Cazzo

Valerini

Chaim

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: The influence of the placement of a band on the outcomes of one anastomosis gastric bypass (OAGB) has not been appropriately studied yet. OBJECTIVE: To compare early weight loss and glucose metabolism parameters following banded versus non-banded OAGB. METHODS: A prospective randomized study, which evaluated 20 morbidly obese individuals who underwent banded and non-banded OAGB and were followed-up for three months. Weight loss (percentage of excess weight loss - %EWL and percentage of body mass index loss - %BMIL) and glucose metabolism outcomes (glucose, insulin and homeostasis model assessment - HOMA) were compared. RESULTS: The banded group presented a significantly higher %EWL at one month (29.6±5.5% vs 17.2±3.4%; P<0.0001) and two months post-surgery (46±7% vs 34.2±9%; P=0.004544), as well as a significantly higher %BMIL at one month (9.7±1.1% vs 5.8±0.8%; P<0.0001), two months (15±1.4% vs 11.5±2.1; P=0.000248), and three months (18.8±1.8% vs 15.7±3.2%; P=0.016637). At three months, banded OAGB led to significant decreases of insulin (14.4±4.3 vs 7.6±1.9; P=0.00044) and HOMA (3.1±1.1 vs 1.5±0.4; P=0.00044), whereas non-banded OAGB also led to significant decreases of insulin (14.8±7.6 vs 7.8±3.1; P=0.006) and HOMA (3.2±1.9 vs 1.6±0.8; P=0.0041). The percent variation of HOMA did not significantly differ between banded and non-banded OAGB (P=0.62414); overall, the percent variation of HOMA was not correlated with %EWL (P=0.96988) or %BMIL (P=0.82299). CONCLUSION: Banded OAGB led to a higher early weight loss than the standard technique. Banded and non-banded OAGB led to improvements in insulin resistance regardless of weight loss.

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“…All these mechanisms are conducted to avoid bile reflux. However, gastric physiology is not only a mechanical event 4 , 33 , 37 , 6 , 30 , 55 , 48 , 32 , 42 , 8 , 7 . Up to now in the available literature concerning to SAGB, only clinical studies have been reported, specially focused in the weight loss and improvement of comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Single Anastomosis Gastric Bypass (One Anastomosis Gastric Bypass or Mini Gastric Bypass): The Experience With Billroth Ii Must Be Considered and Is a Challenge for the Next Years

Braghetto

Csendes

2017

ABCD, arq. bras. cir. dig.

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Introduction: Single anastomosis gastric bypass (one anastomosis gastric bypass or mini-gastric bypass) has been presented as an option of surgical treatment for obese patients in order to reduce operation time and avoiding eventual postoperative complications after Roux-en-Y gastric bypass.The main late complication could be related to bile reflux. Aim: To report the experiences published after Billroth II anastomosis and its adverse effects regarding symptoms and damage on the gastric and esophageal mucosa. Method: For data recollection Medline, Pubmed, Scielo and Cochrane database were accessed, giving a total of 168 papers being chosen 57 of them. Results: According the reported results during open era surgery for peptic disease and more recent results for gastric cancer surgery, bile reflux and its consequences are more frequent after Billroth II operation compared to Roux-en-Y gastrojejunal anastomosis. Conclusion: These findings must be considered for the indication of bariatric surgery.

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Weight loss and improvement of lipid profiles in morbidly obese patients after laparoscopic one-anastomosis gastric bypass: 2-year follow-up

Abstract: OAGB leads to substantial and durable WL in morbidly obese patients after a 2-year follow-up. Postoperative lipid profiles significantly improved; these changes translate into theoretical relevant cardiovascular risk benefits.

Cited by 38 publications

References 24 publications

Laparoscopic One-Anastomosis Gastric Bypass: Technique, Results, and Long-Term Follow-Up in 1200 Patients

Laparoscopic One-Anastomosis Gastric Bypass: Technique, Results, and Long-Term Follow-Up in 1200 Patients

Early Weight Loss Outcomes and Glucose Metabolism Parameters After Banded Versus Non-Banded One Anastomosis Gastric Bypass: A Prospective Randomized Trial

Single Anastomosis Gastric Bypass (One Anastomosis Gastric Bypass or Mini Gastric Bypass): The Experience With Billroth Ii Must Be Considered and Is a Challenge for the Next Years

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