Weekly docetaxel monotherapy for advanced gastric or esophagogastric junction cancer

Abbrederis, K.; Lorenzen, Sylvie; Weikersthal, Ludwig Fischer von; Vehling-Kaiser, U.; Schuster, Tibor; Röthling, N.; Peschel, Christian; Lordick, Florian

doi:10.1016/j.critrevonc.2007.12.001

Cited by 13 publications

(2 citation statements)

References 19 publications

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“…Therefore, in combination with capecitabine [4], 5-fluorouracil [5] or S-1 [6] oxaliplatin is the most commonly used form of platinum derivatives for the treatment of GC. Most GC patients receive chemotherapy doublets [7], but less intensive chemotherapy regimens may be preferred in some circumstances due to e.g., suboptimal patient performance status [8]. In the past, tri-drug chemotherapy, such as a combination of EOX (epirubicin, oxaliplatin, and capecitabine) [9] or DCF (docetaxel, cisplatin, fluorouracil) [10], was considered the standard of care.…”

Section: Introductionmentioning

confidence: 99%

Combined Neutrophil-to-Lymphocyte and Platelet-Volume-to-Platelet Ratio (NLR and PVPR Score) Represents a Novel Prognostic Factor in Advanced Gastric Cancer Patients

Konopka

Micek

Ochenduszko

et al. 2021

JCM

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Background: Chemotherapy is a cornerstone of treatment in advanced gastric cancer (GC) with a proven impact on overall survival, however, reliable predictive markers are missing. The role of various inflammatory markers has been tested in gastric cancer patients, but there is still no general consensus on their true clinical applicability. High neutrophil-to-lymphocyte (NLR) and low (medium)-platelets-volume-to-platelet ratio (PVPR) are known markers of unspecific immune system activation, correlating significantly with outcomes in advanced GC patients. Methods: Metastatic GC patients (N:155) treated with chemotherapy +/− trastuzumab were enrolled in this retrospective study. Pre-treatment NLR and PVPR, as well as other inflammatory markers were measured in peripheral blood. Univariate Cox regression was conducted to find markers with a significant impact on overall survival (OS) and progression-free survival (PFS). Spearman correlation and Cohen’s kappa was used to analyze multicollinearity. Multiple multivariable Cox regression models were built to study the combined impact of NLR and PVPR, as well as other known prognostic factors on OS. Results: Elevated NLR was significantly associated with increased risk of death (HR = 1.95; 95% CI: 1.17–3.24), and lower PVPR was significantly associated with improved outcomes (HR = 0.53; 95% CI: 0.32–0.90). A novel inflammatory marker, based on a combination of NLR and PVPR, allows for the classification of GC patients into three prognostic groups, characterized by median OS of 8.4 months (95% CI 5.8–11.1), 10.5 months (95% CI 8.8–12.1), and 15.9 months (95% CI 13.5–18.3). Conclusion: The NLR and PVPR score (elevated NLR and decreased PVPR) is a marker of detrimental outcome of advanced GC patients treated with chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Combined Neutrophil-to-Lymphocyte and Platelet-Volume-to-Platelet Ratio (NLR and PVPR Score) Represents a Novel Prognostic Factor in Advanced Gastric Cancer Patients

Konopka

Micek

Ochenduszko

et al. 2021

JCM

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“… 11 Docetaxel (D) has shown activity in GC without evidence of cross‐resistance with platinum compounds. 12 , 13 , 14 When combined with C and F (DCF) in a 3‐weekly regimen, it increases response rate (RR), median time to progression (mTTP), and mOS as compared to CF, but at the cost of higher rates of grade ≥3 adverse events (69% vs. 59%) and febrile neutropenia (FN) (29% vs. 12%). 15 Therefore, routine use of DCF in clinical practice for patients with advanced gastric and GEJ adenocarcinoma remains limited.…”

Section: Introductionmentioning

confidence: 99%

Fortnightly or fractionated weekly docetaxel–cisplatin–5‐FU as first‐line treatment in advanced gastric and gastroesophageal junction adenocarcinoma: The randomized phase II DoGE study

Deleporte

Eynde

Forget³

et al. 2021

Cancer Medicine

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Background While docetaxel/cisplatin/5‐fluorouracil (DCF) outperforms CF in first‐line gastric adenocarcinoma, toxicity remains an issue. Methods This multicenter phase II trial randomized chemonaïve metastatic gastric adenocarcinoma patients to fractionated weekly DCF (D 40 mg/m2, C 35 mg/m², F 1800 mg/m² over 24 h, on days 1 and 8 every 3 weeks, arm (1) or fortnightly DCF (D 50 mg/m2, C 50 mg/m², F 2000 mg/m² over 48 h every 2 weeks, arm (2). Prophylactic granulocyte colony‐stimulating factor (G‐CSF) was not allowed. The primary endpoint was the rate of febrile neutropenia within the first six treatment weeks (early FN). Results A total of 106 eligible patients were recruited. The early and overall FN rates were 9.5% and 17% in arm 1, respectively, and 5.9% and 8% in arm 2, respectively. Grade ≥3 toxicities occurred in 81% of patients in arm 1 and 90% of patients in arm 2, the most common being neutropenia (33% vs. 61%), fatigue (27% vs. 25%), vomiting (21% vs. 12%), anorexia (19% vs. 18%), and diarrhea (17% vs. 10%). Median progression‐free survival and overall survival were 5.1 (95% CI, 3.2–6.5) and 8.2 months (95% CI, 6.0–14.5), respectively, in arm 1 and 5.2 (95% CI, 3.0–6.9) and 11.9 months (95% CI, 7.4–15.9), respectively, in arm 2. Conclusions Fractionated weekly and fortnightly DCF regimens are associated with a low risk of early FN, and a better hematological toxicity profile as compared to historical DCF without compromising efficacy. Both regimens offer greater convenience removing the need for systematic use of prophylactic G‐CSF.

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Combining Platinums in Gastric Cancer

Lordick

Jäger

2009

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

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Weekly docetaxel monotherapy for advanced gastric or esophagogastric junction cancer

Cited by 13 publications

References 19 publications

Combined Neutrophil-to-Lymphocyte and Platelet-Volume-to-Platelet Ratio (NLR and PVPR Score) Represents a Novel Prognostic Factor in Advanced Gastric Cancer Patients

Combined Neutrophil-to-Lymphocyte and Platelet-Volume-to-Platelet Ratio (NLR and PVPR Score) Represents a Novel Prognostic Factor in Advanced Gastric Cancer Patients

Fortnightly or fractionated weekly docetaxel–cisplatin–5‐FU as first‐line treatment in advanced gastric and gastroesophageal junction adenocarcinoma: The randomized phase II DoGE study

Combining Platinums in Gastric Cancer

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