Wearable biomolecule smartsensors based on one-step fabricated berlin green printed arrays

Ma, Jie; Jiang, Yu; Shen, Liuxue; Ma, Hongting; Sun, Tongrui; Lv, Fengjuan; Kiran, Almas; Zhu, Nan

doi:10.1016/j.bios.2019.111637

Cited by 22 publications

(16 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The apparent Michaelis–Menten constant ( K app m ) of the all-inkjet-printed glucose biosensor was estimated to be 887 μM using the electrochemical version of the Lineweaver–Burk equation (Figure S23). A low value of 887 μM of the all-inkjet-printed glucose biosensor suggests that the enzyme electrode possessed high affinity, as well as high enzyme catalytic activity toward glucose molecules. − …”

Section: Results and Discussionmentioning

confidence: 99%

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials

Kang

Lee

Hwang

et al. 2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Nanostructured flexible electrodes with biological compatibility and intimate electrochemical coupling provide attractive solutions for various emerging bioelectronics and biosensor applications. Here, we develop all-inkjet-printed flexible nanobio-devices with excellent electrochemical coupling by employing amphiphilic biomaterial, an M13 phage, numerical simulation of single-drop formulation, and rational formulations of nanobio-ink. Inkjet-printed nanonetwork-structured electrodes of single-walled carbon nanotubes and M13 phage show efficient electrochemical coupling and hydrostability. Additive printing of the nanobio-inks also allows for systematic control of the physical and chemical properties of patterned electrodes and devices. All-inkjet-printed electrochemical field-effect transistors successfully exhibit pH-sensitive electrical current modulation. Moreover, all-inkjet-printed electrochemical biosensors fabricated via sequential inkjet-printing of the nanobio-ink, electrolytes, and enzyme solutions enable direct electrical coupling within the printed electrodes and detect glucose concentrations at as low as 20 μM. Glucose levels in sweat are successfully measured, and the change in sweat glucose levels is shown to be highly correlated with blood glucose levels. Synergistic combination of additive fabrication by inkjet-printing with directed assembly of nanostructured electrodes by functional biomaterials could provide an efficient means of developing bioelectronic devices for personalized medicine, digital healthcare, and emerging biomimetic devices.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials

Kang

Lee

Hwang

et al. 2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…[ 140,160,184 ] Owing to advancement of materials, fabrication techniques, and sampling approaches, a number of skin‐interfaced biosensors have been validated for their real‐time CGM in sweat during physiological activities ( Figure ). [ 135–161,185 ] Electrochemical sensors are the most commonly used method for wearable device design owing to their high sensitivity and simplicity, low‐cost fabrication, high speed, and high analytical performance. [ 186–188 ] Several strategies have been developed to optimize the on‐body sensing capability of these wearable electrochemical sensors.…”

Section: Emergence Of On‐body Wearable Glucose Continuous Monitoringmentioning

confidence: 99%

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

Phan

Hoang

et al. 2021

Adv Materials Technologies

View full text Add to dashboard Cite

The COVID‐19 pandemic has continued to spread rapidly, and patients with diabetes are at risk of experiencing rapid progression and poor prognosis for appropriate treatment. Continuous glucose monitoring (CGM), which includes accurately tracking fluctuations in glucose levels without raising the risk of coronavirus exposure, becomes an important strategy for the self‐management of diabetes during this pandemic, efficiently contributing to the diabetes care and the fight against COVID‐19. Despite being less accurate than direct blood glucose monitoring, wearable noninvasive systems can encourage patient adherence by guaranteeing reliable results through high correlation between blood glucose levels and glucose concentrations in various other biofluids. This review highlights the trending technologies of glucose sensors during the ongoing COVID‐19 pandemic (2019–2020) that have been developed to make a significant contribution to effective management of diabetes and prevention of coronavirus spread, from off‐body systems to wearable on‐body CGM devices, including nanostructure and sensor performance in various biofluids. The advantages and disadvantages of various human biofluids for use in glucose sensors are also discussed. Furthermore, the challenges faced by wearable CGM sensors with respect to personalized healthcare during and after the pandemic are deliberated to emphasize the potential future directions of CGM devices for diabetes management.

show abstract

“…To achieve painless and harmless self-monitoring of diabetes, noninvasive wearable sensors (e.g., sweat, saliva, tear, etc.) with high selectivity and a low detection limit have been put forward. − Generally, they could be divided into two categories, enzymatic biosensors and enzyme-free biosensors. Compared with enzymatic biosensors, an enzyme-free sensing platform has the properties of nonenzyme immobilization, simple operation, and reusability, which would be helpful for noninvasive wearable analytical detection.…”

Section: Introductionmentioning

confidence: 99%

Facet-Dependent Cu₂O Electrocatalysis for Wearable Enzyme-Free Smart Sensing

et al. 2021

Self Cite

View full text Add to dashboard Cite

Exploiting electrocatalysis for wearable enzyme-free biosensors and biofuel cells has recently greatly developed in preliminary medical diagnosis and human healthcare fields. Herein, several facet-controlled cuprous oxide (Cu2O) nanostructures have been systematically fabricated to investigate the facet-dependent electrocatalysis mechanism. As a result, cuboctahedral Cu2O with a hollow structure exhibits optimal sensing performance for glucose detection compared with octahedral or extended hexapod Cu2O. The facet-dependent sensing process reveals that Cu2O{100} and Cu2O{111} facets are helpful in acquiring a higher interaction with enzyme-free substrates and accelerating electron transfer, respectively, to improve electrocatalytic activity. As a proof of concept, combined with a portable wireless device, wearable Cu2O enzyme-free biofuel cell systems can achieve glucose sensing by both open circuit potential and power output signals, which would potentially be used for a wearable enzyme-free energy platform. Therefore, this wearable enzyme-free smart sensing concept would help in the targeted establishment of biomarker electrocatalysts, and further offers considerable promise for the development of biofuel cells in the wearable healthcare monitoring field.

show abstract

Wearable biomolecule smartsensors based on one-step fabricated berlin green printed arrays

Cited by 22 publications

References 57 publications

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

Facet-Dependent Cu₂O Electrocatalysis for Wearable Enzyme-Free Smart Sensing

Contact Info

Product

Resources

About

Wearable biomolecule smartsensors based on one-step fabricated berlin green printed arrays

Cited by 22 publications

References 57 publications

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

Facet-Dependent Cu2O Electrocatalysis for Wearable Enzyme-Free Smart Sensing

Contact Info

Product

Resources

About

Facet-Dependent Cu₂O Electrocatalysis for Wearable Enzyme-Free Smart Sensing