We study a system whose dynamics are driven by non-Poisson, renewal, and nonergodic events. We show that external perturbations influencing the times at which these events occur violate the standard fluctuation-dissipation prescription due to renewal aging. The fluctuation-dissipation relation of this Letter is shown to be the linear response limit of an exact expression that has been recently proposed to account for the luminescence decay in a Gibbs ensemble of semiconductor nanocrystals, with intermittent fluorescence. The main purpose of this Letter is to go beyond the ergodic condition and to propose a generalization of FDT compatible with the anomalous properties of intermittent fluorescence, denoted as blinking quantum dots (BQD) [5], including the important renewal property [6]. We note that Verberk et al. [7], using only the renewal and nonexponential distribution revealed by experimental observation, predicted an inverse power-law luminescence decay fitting the experiment results. They did not, however, make the connection between their prediction and the breakdown of FDT. To establish a connection between the theoretical prediction of Verberk et al. and the FDT breakdown, we write the most general form of the response of a physical system to a time-dependent perturbation:where A is a system variable, whose mean value in the absence of perturbation is assumed to vanish. Another system variable B is coupled to the time-dependent perturbation P t of strength and AB t; t 0 is called the response function. In the recent condensed matter literature [1] the assumption is made that the external perturbation corresponds to adding to the unperturbed Hamiltonian the interaction term H pert B P t , and the adoption of the Kubo approach [3] is shown to generate the response functionwhere the brackets denote an average on either the classical or the quantum equilibrium probability distribution. This simple formula does not imply that the correlation function depends on t ÿ t 0 , and is consequently a generalization of the LRT of Kubo [3] obtained using Liouville or Liouvillelike equations that determine the time evolution of the variable probability. Herein we shift the focus from variables to events, an event being a collision that may produce an abrupt change in the value of a variable. We assume these events to be the renewal, non-Poisson, and nonergodic events studied by Barkai and co-workers [8], that A B S and that the variable S has only two distinct values, S 1. Finally, we assume that the external perturbation changes the prescription that determines the times at which events occur, namely, the times at which the variable S may, or may not, change its sign. This final assumption reveals the lack of a Hamiltonian formalism, a condition shared by Refs. [5,7].We define the nonstationary autocorrelation function where t; t 0 is the waiting-time distribution density of age t 0 [8,9]. Note that Eq. (4), as well as Eq. (2), is a generalization of the Kubo FDT [3]. When t;t 0 Þ t ÿ t 0 , d=dt t; t 0