We have to do more for former paediatric renal transplant recipients!

Filler, Guido; Ferris, Maria

doi:10.1111/tri.13058

Cited by 6 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast, our study is in agreement with the more recent study by Brownbridge and Fielding, who found no significant difference between dialysis and post‐transplant patients. Recent data from Finland suggest that the problem only worsens upon transition to adulthood . The quality of life among former pediatric renal transplant recipients in early adulthood is worse than that of pediatric cancer survivors, even if there is good graft function.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High depression rates among pediatric renal replacement therapy patients: A cross‐sectional study

Cuellar

Puente

Moraria

et al. 2019

Pediatric Transplantation

Self Cite

View full text Add to dashboard Cite

Depression is common in pediatric chronic kidney disease (CKD) patients. Depression is associated with inferior long‐term outcomes. There is a paucity of studies that evaluate depression and possible associated factors in children and adolescents requiring renal replacement therapy (RRT). Cross‐sectional study using Children`s Depression Inventory in a cohort from a large urban center. Forty‐seven pediatric RRT patients (26 female, 12 peritoneal dialysis (PD), 17 hemodialysis (HD), 18 after successful kidney transplantation (KTX)) with a mean age at the time of assessment of 13.9 ± 2.3 years. Symptoms of depression were found in 30 (64%, 11KTX, 11HD, 8PD) patients. We found no association with age, sex, renal function, dialysis adequacy markers, anemia, electrolytes, socioeconomical status, IQ, educational status of the child including school attendance and distance from the house to the hospital among HD patients. Significant differences only applied for age at diagnosis of CKD, RRT vintage and deceased donor for KTX. The group with depression had a higher age at diagnosis of CKD and less time on RRT than the group without depression. There was also a high rate of depression in KTX patients. In this cohort, depression was a common comorbidity of RRT in children and adolescents with RRT and also for KTX patients, even though biomarkers of kidney function and time for RRT are much improved.

show abstract

Section: Discussionmentioning

confidence: 99%

“…30 In an older study, Reynolds et al 30 TA B L E 2 Socioeconomical characteristics adulthood. 32,33 The quality of life among former pediatric renal transplant recipients in early adulthood is worse than that of pediatric cancer survivors, even if there is good graft function.…”

Section: Ing Depression Scores Among Pediatric Ckd Patients In Centralmentioning

confidence: 99%

High depression rates among pediatric renal replacement therapy patients: A cross‐sectional study

Cuellar

Puente

Moraria

et al. 2019

Pediatric Transplantation

Self Cite

View full text Add to dashboard Cite

show abstract

“…We need global strategies and clinical trials to reduce cardiovascular risks. We must do more to improve the survival and quality of life of our patients, 14 which is worse than that of pediatric cancer survivors 15 . We have learned about the potential cardiovascular benefits of sodium‐glucose cotransporter 2 inhibitors (SGLT2i), 16 as these medications have been associated with the reduction of skin sodium in sodium MRI studies 17 .…”

Section: Future Directionsmentioning

confidence: 99%

The ongoing need to improve long‐term patient survival of pediatric solid organ recipients

Filler

Sharma

Ferris

2023

Pediatric Transplantation

Self Cite

View full text Add to dashboard Cite

The ongoing need to improve long-term patient survival of pediatric solid organ recipients 1 | INTRODUC TI ON Solid organ transplantation (SOT) is the therapy of choice for endstage organ disease in children and adolescents. Due to improved immunosuppression, better management of infections and improved surgical techniques, patient survival has improved over the past decades. However, survival is limited, mostly due to cardiovascular disease, 1 infection, 2 cancer 3 and heart failure/arrhythmias (particularly for heart transplant recipients). 4 Kim and Marks reported 10year survivals in SOT patients as follows: 86.6%-92.4% for kidney (depending on donor source), 77% for liver, 58% for heart, 46% for intestines and 44% for lung (at 7 years). 5 However, we need data on longer-term outcomes, preferably country-wide or from larger jurisdictions, to develop strategies for improved patient survival. In this context, we are delighted to see the manuscript by Rebekka Salonen et al. reporting long-term mortality in Finland from 1982 to 2015. 6 4 | CON CLUS IONS Rebekka Salonen and colleagues have narrowed our knowledge gap about the long-term survival of SOT recipients and pointed to the increased risk of death compared to their peers. With interdisciplinary collaboration, comorbidities beyond the organ-specific issues need to be carefully screened to identify targets of prevention among SOT recipients. 24 AUTH O RCO NTR I B UTI O N S G Filler conceived the original study idea, provided intellectual insight, wrote the first draft, imported all the literature and edited multiple versions of the manuscript. M Ferris and A Sharma provided major intellectual insight into the manuscript as well as the manuscript writing and editing of each version.

show abstract

“…Males especially have a very low quality of life with short stature, as was shown in a nationwide study comparing the quality of life of young adults with pediatric cancer or CKD (see Fig. 2) [25, 66]. Patient factors (needle phobia), caregiver factors (low focus on final height), and insurance coverage are major barriers for the prescription of recombinant human growth hormone [67].…”

Section: Chronic Kidney Disease/end-stage Kidney Disease In Adolescents and Young Adultsmentioning

confidence: 99%

An Interdisciplinary Approach to Optimize the Care of Transitioning Adolescents and Young Adults with CKD

Ferris

Martínez

Velázquez³

et al. 2021

Blood Purif

Self Cite

View full text Add to dashboard Cite

Adolescents and young adults (AYAs) with CKD or end-stage kidney disease (ESKD) have unique medical, dental, psychosocial, neurocognitive, and academic needs and require close interdisciplinary collaboration to optimize their care. The etiology of CKD in AYAs is diverse compared to older adults. With their continuously improved survival, AYAs must start preparation for health-care transition (HCT) from pediatric- to adult-focused health care in the pediatric setting and it must continue at the adult-focused setting, given that their brain maturation and self-management skill acquisition occur until their mid-20s. While the growth and physical maturation of most visible body parts occur before 18 years of age, the prefrontal cortex of the brain, where reasoning, impulse control, and other higher executive functions reside, matures around 25 years of age. The HCT process must be monitored using patient- and caregiver-measuring tools to guide interventions. The HCT process becomes more complex when patients and/or caregivers have a language barrier, different cultural beliefs, or lower literacy levels. In this article, we discuss the unique comorbidities of pediatric-onset CKD/ESKD, provide information for a planned HCT preparation, and suggest interdisciplinary coordination as well as cultural and literacy-appropriate activities to achieve optimal patient outcomes.

show abstract

We have to do more for former paediatric renal transplant recipients!

Cited by 6 publications

References 17 publications

High depression rates among pediatric renal replacement therapy patients: A cross‐sectional study

High depression rates among pediatric renal replacement therapy patients: A cross‐sectional study

The ongoing need to improve long‐term patient survival of pediatric solid organ recipients

An Interdisciplinary Approach to Optimize the Care of Transitioning Adolescents and Young Adults with CKD

Contact Info

Product

Resources

About