2023
DOI: 10.3390/ijms24065895
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Wavelength-Dependent Effects of Photobiomodulation for Wound Care in Diabetic Wounds

Abstract: Photobiomodulation, showing positive effects on wound healing processes, has been performed mainly with lasers in the red/infrared spectrum. Light of shorter wavelengths can significantly influence biological systems. This study aimed to evaluate and compare the therapeutic effects of pulsed LED light of different wavelengths on wound healing in a diabetic (db/db) mouse excision wound model. LED therapy by Repuls was applied at either 470 nm (blue), 540 nm (green) or 635 nm (red), at 40 mW/cm2 each. Wound size… Show more

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Cited by 4 publications
(3 citation statements)
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“…A total of 44 studies were conducted to evaluate impact of PBM on wound healing, including 31 studies on preclinical models ( 84 114 ) and 13 studies on humans ( 45 , 47 , 48 , 115 124 ) ( Table 6 ). In preclinical models, PBM had a predominantly positive effect on wound healing in 94% of studies.…”
Section: Resultsmentioning
confidence: 99%
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“…A total of 44 studies were conducted to evaluate impact of PBM on wound healing, including 31 studies on preclinical models ( 84 114 ) and 13 studies on humans ( 45 , 47 , 48 , 115 124 ) ( Table 6 ). In preclinical models, PBM had a predominantly positive effect on wound healing in 94% of studies.…”
Section: Resultsmentioning
confidence: 99%
“…Only one study, which poorly described PBM parameters, did not report a positive effect of PBM ( 104 ). Most studies utilized wavelengths in the red to near-infrared spectrum, whereas studies investigating green wavelengths did not report positive effects of PBM ( 84 , 94 ). In clinical studies, the majority (92%) reported a positive effect of PBM on chronic ulcers healing.…”
Section: Resultsmentioning
confidence: 99%
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