Water dispersed fluorescent organic aggregates for the picomolar detection of ClO4−in water, soil and blood serum and the attogram detection of ClO4−in the solid state by a contact mode method

Kumar, Rahul; Sandhu, Sana; Singh, Prabhpreet; Kumar, Subodh

doi:10.1039/c6tc01891b

Cited by 11 publications

(3 citation statements)

References 49 publications

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“…The turbidity was due to the formation of aggregates, as observed by dynamic light scattering (DLS) experiments (Figure S1 in the Supporting Information). It was reported that the aggregates were used as sensors and catalysts [57–61] . High‐resolution images of the aggregates were recorded by using the atomic force microscopy (AFM) technique to investigate the sizes and morphologies of the aggregates (Figure 3 B,C).…”

Section: Resultsmentioning

confidence: 99%

Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l‐Histidine: Demonstration of the Acetylcholine Esterase Activity

Singh

Saini

Mayank

et al. 2021

Chemistry A European J

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An anion‐mediated preorganization approach was used to design and synthesize the benzimidazolium‐based calix compound R1⋅2 ClO4−. X‐ray crystallography analysis revealed that the hydrogen‐bonding interactions between the benzimidazolium cations and N,N‐dimethylformamide (DMF) helped R1⋅2 ClO4− encapsulate DMF molecule(s). A nanoreactor, with R1⋅2 ClO4− and l‐histidine (l‐His) as the components, was fabricated by using a neutralization method. The nanoreactor could detoxify paraoxon in 30 min. l‐His played a vital role in this process. Paraoxonase is a well‐known enzyme used for pesticide degradation. The Ellman's reagent was used to determine the percentage inhibition of the acetylcholinesterase (AChE) activity in the presence of the nanoreactor. The results indicated that the nanoreactor inhibited AChE inhibition.

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Section: Resultsmentioning

confidence: 99%

Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l‐Histidine: Demonstration of the Acetylcholine Esterase Activity

Singh

Saini

Mayank

et al. 2021

Chemistry A European J

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“…The rate of radiative decay of the excited state decreases as the concentration of ATP increases in solution, whereas the lifetime of the excited state increases. This transformation is due to the formation of aggregates where properties of the excited state are different and lead to an increased lifetime, 79 whereas a decreasing radiative decay constant is attributed to quenching of the excimer emission. We observed a minor change in the nonradiative decay constant upon addition of ATP to the R3 solution.…”

Section: Crystal Growth and Designmentioning

confidence: 99%

ATP Induced Modulation in π–π Stacking Interactions in Pyrene Based Zinc Complexes: Chemosensor Study and Quantitative Investigation of Apyrase Activity

Singh

Raj

Dubowski

et al. 2018

Crystal Growth & Design

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Fluorescent zinc complexes of 1,2-disubstituted benzimidazole (R1–R3) have been synthesized and characterized using single crystal X-ray diffraction. The ligands L1–3 were found to be less emissive due to photoinduced electron transfer (PET) mechanism originated from the electron pair of benzimidazole nitrogen. The complexation of ligands with Zn(II) not only enhances the fluorescent intensity; it also orients the ligands to a new packing. It was observed that the aromatic unit plays a decisive role in the packing of the molecules. The complex R1 has extended the coordination through C–H···π interaction, whereas complex R2 involved C–H···π interaction and C–H···Br interaction for packing in supramolecular architecture. Among these complexes, R3 showed the most interesting noncovalent interaction pattern involving C–H···π interaction, C–H···Br interaction, and π–π stacking between pyrene rings. These noncovalent interactions govern photophysical properties that are sensitive toward the microenvironment. Thus, by altering these interactions, the selective sensing for a particular analyte can be achieved. The complexes R1 and R2 have shown enhanced emission intensity upon interacting with adenosine triphosphate (ATP) competitively in the presence of some other tested anions. A ratiometric change in emission spectra of the complex R3 was observed upon binding with ATP in semiaqueous medium offering the lowest detection limit of 15 nM. Upon interaction with ATP, the π–π stacking between pyrene rings breaks and results in a decrease in excimer emission at 470 nm and increases in monomeric emission intensity at 410 nm. The AFM (Atomic force microscopy) images of receptor R3 show that upon addition of ATP to the R3 solution, solvent mediated aggregation takes place, which results in the ratiometric detection. In the dimethylformamide solvent system, aggregates were formed, whereas in a water/tetrahydrofuran solvent system the clear solution was converted to a highly viscous gel. To investigate the applications of the prepared sensor, the fluorescence response of HeLa cells enriched with ATP was observed using fluorescence microscopy. The fluorescence modulation of the sensor in living cells makes the receptor practically applicable in a biological environment. Quantitative analysis of apyrase activity has shown that the presented sensor R3 is capable of monitoring the hydrolysis process in the biological system.

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“…23,24 Currently, due to the weak coordination behavior of perchlorate, 25 efforts to develop its optical probes have met limited success. [26][27][28] Although several luminescent turn-on perchlorate probes have been reported, such as the pyridinium-functionalized tetraphenylethene compound 27 and ionic iridium(III) complex, 26 none exhibit simultaneously colorimetric response. The conventional construction by integrating a chromophore onto the luminophore is poorly feasible for the perchlorate dual-mode sensor, owing to the extremely limited number of perchlorate chromophore (methylene blue is the most oen used, but with a low-contrast color change from blue to purple).…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive dual-mode visualization of perchlorate in water, soil and air boosted by close and stable Pt–Pt packing endowed low-energy absorption and emission

et al. 2022

J. Mater. Chem. A

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Water dispersed fluorescent organic aggregates for the picomolar detection of ClO₄⁻in water, soil and blood serum and the attogram detection of ClO₄⁻in the solid state by a contact mode method

Abstract: An aggregation–disaggregation based molecular probe allows the detection of 10 pM ClO4−in solution and 6 × 10−18g cm−2ClO4−in the solid state by a contact mode method with a selectivity of ∼10 000 over other inorganic anions.

Cited by 11 publications

References 49 publications

Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l‐Histidine: Demonstration of the Acetylcholine Esterase Activity

Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l‐Histidine: Demonstration of the Acetylcholine Esterase Activity

ATP Induced Modulation in π–π Stacking Interactions in Pyrene Based Zinc Complexes: Chemosensor Study and Quantitative Investigation of Apyrase Activity

Ultrasensitive dual-mode visualization of perchlorate in water, soil and air boosted by close and stable Pt–Pt packing endowed low-energy absorption and emission

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