Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015

Puig-Barberà, Joan; Mira‐Iglesias, Ainara; Tortajada‐Girbés, Miguel; López‐Labrador, F. Xavier; Librero-López, J; Díez‐Domingo, Javier; Carballido‐Fernández, Mario; Carratalá‐Munuera, C; Correcher-Medina, Patricia; Gil-Guillén, Vicente Francisco; Limón-Ramírez, Ramón; Mollar-Maseres, Joan; Otero-Reigada, M.C.; Schwarz, Herman

doi:10.1016/j.vaccine.2017.09.035

Cited by 55 publications

(54 citation statements)

References 30 publications

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“…Our estimate was lower than those reported from the United States (61%, 95% CI: 52%, 68%) [19] and Canada (58.5%, 95% CI: 43.9%, 69.3%) [20], which could attribute to different circulating viruses in the two regions. In the 2013- 14 for the elderly aged 65 years or above [20] while a similar study in Spain estimated a 248 moderate influenza VE of 33% (6%, 53%) and 40% (13%, 59%) in all age groups and the elderly, respectively [23]. The lack of effectiveness of influenza vaccination might be 250 attributable to the mismatch in the H3N2 component.…”

Section: Discussionmentioning

confidence: 97%

Influenza vaccine effectiveness in preventing hospitalization among Beijing residents in China, 2013–15

Qin

Zhang

et al. 2016

Vaccine

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Section: Discussionmentioning

confidence: 97%

Influenza vaccine effectiveness in preventing hospitalization among Beijing residents in China, 2013–15

Qin

Zhang

et al. 2016

Vaccine

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“…Some studies have indicated the benefits of vaccination can extend into the following season [ 5 , 10 , 11 , 12 , 13 , 14 ] while another study indicated that such antibody levels drop below accepted protective levels within a year [ 15 ]. Measurements of HI titers 180 days post-vaccination suggest that a significant portion of vaccinated subjects retain protective titers up to this point [ 16 ], but it is known that a reduction in vaccine effectiveness occurs later in the season, or in between seasons [ 17 , 18 , 19 , 20 ]. This has implications for those travelling between the northern and southern hemispheres, military personal posted to different regions of the globe, and at risk people vaccinated early during a season when influenza virus infections emerge late in the season.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination

et al. 2018

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The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts. There is a need for better understanding of how vaccine responses are affected by early exposures to influenza viruses. In this analysis of hemagglutination inhibition (HI) antibody responses in two cohorts of military personnel we noticed differences related to age, sex, prior vaccination, deployment and birth year. These data suggest that HI antibody production, in response to influenza vaccination, is affected by these factors. The magnitude of this antibody response is associated with, among other factors, the influenza strain that circulated following birth.

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“…Although the influenza vaccination is widely used nowadays, it remains an important health threat worldwide. The effectiveness of current influenza vaccination is not adequate, and protection rates in elderly people are probably as low as 30% [ 2 , 42 , 43 ]. Multiple factors are responsible for the low protective efficacy; these include antigen drift, seasonal mismatch, and manufacture technique limitations [ 2 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

et al. 2018

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Influenza virus infection is a major global public health problem, and the efficacy of influenza vaccination is not satisfactory. Vitamin D is involved in many immune-mediated inflammatory processes. The impact of vitamin D levels on the immunogenic response to influenza vaccination is not clear. We performed a comprehensive literature search and systematic review of studies that investigated vitamin D and influenza vaccination. Data pertaining to study population, vaccine components, vitamin D levels, and immunogenic response were analyzed. Nine studies, with a combined study population of 2367 patients, were included in the systematic review. Four studies were included in the meta-analysis to investigate the influence of vitamin D deficiency (VDD) on the seroprotection (SP) rates and seroconversion (SC) rates following influenza vaccination. We found no significant association between vitamin D level and the immunogenic response to influenza vaccination. However, strain-specific differences may exist. We observed lower SP rates of influenza A virus subtype H3N2 (A/H3N2) and B strain in VDD patients than patients with normal vitamin D levels (A/H3N2: 71.8% vs. 80.1%, odds ratio (OR): 0.63, 95% confidence interval (CI): 0.43–0.91, p = 0.01; B strain: 69.6% vs. 76.4%, OR: 0.68, 95% CI: 0.5–0.93, p = 0.01). However, the SP rates of A/H1N1 and SC rates of all three strains were not significantly different in VDD and control groups. In conclusion, no association was observed between VDD and immunogenic response to influenza vaccination.

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Waning protection of influenza vaccination during four influenza seasons, 2011/2012 to 2014/2015

Abstract: Waning of vaccine protection was observed among individuals aged 65years old or over in two A(H3N2)-dominant influenza seasons.

Cited by 55 publications

References 30 publications

Influenza vaccine effectiveness in preventing hospitalization among Beijing residents in China, 2013–15

Influenza vaccine effectiveness in preventing hospitalization among Beijing residents in China, 2013–15

The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

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