Waldenstrom macroglobulinemia with an IgM-kappa antiepidermal basement membrane zone antibody

Cobb, M. W.

doi:10.1001/archderm.128.3.372

Cited by 11 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…was thought to be EBA; neither study characterized the circulating anti‐BMZ IgM antibodies. The case reported by Cobb et al . presented with a pruritic popular eruption but no blisters, had IgM deposits within the BMZ and circulating anti‐BMZ IgM antibodies localizing to both sides of skin split with 1 mol/L NaCl.…”

Section: Reportmentioning

confidence: 94%

See 1 more Smart Citation

Immunobullous dermatosis associated with Waldenström macroglobulinaemia treated with rituximab

Chattopadhyay

Rytina

Dada

et al. 2013

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Waldenström macroglobulinaemia (WM) is a chronic lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraprotein. Specific cutaneous features of WM include neoplastic cell infiltrates, IgM storage papules and IgM bullous dermatosis. We report a patient with subepidermal bullous disease associated with WM. Immunofluorescence identified IgM deposition along the basement membrane zone (BMZ) with circulating anti-BMZ IgM antibodies reacting with the dermal side of salt-split skin. The autoantibodies did not react with type VII collagen or laminin 332. Following failed treatment with doxycycline, prednisolone, intravenous immunoglobulin and dapsone, the patient was successfully treated with a modified RCVP regimen (rituximab, cyclophosphamide and prednisolone). To our knowledge, this is the first reported case of IgM bullous disease of WM treated with rituximab.

show abstract

Section: Reportmentioning

confidence: 94%

“…There have been only very few reported cases of IgM bullous disease in WM to date in the English literature . The case reported by Wuepper et al .…”

Section: Reportmentioning

confidence: 99%

Immunobullous dermatosis associated with Waldenström macroglobulinaemia treated with rituximab

Chattopadhyay

Rytina

Dada

et al. 2013

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…The monoclonal IgM produced can also act as an autoantibody to select against myelin-associated glycoprotein causing neuropathy or RBCs causing Coombs positive autoimmune cold hemolytic anemia. The monoclonal IgM protein can also deposit in extracellular spaces of the GI tract, skin or kidneys [6, 7]. Previous cases of nephrotic syndrome associated with WM were treated with cytotoxic agents and corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

A Case of Nephrotic Syndrome With Minimal-Change Disease and Waldenstrom’s Macroglobulinemia

Grabe

Haqqie³

2013

J Clin Med Res

View full text Add to dashboard Cite

Kidney disease is a rare complication of Waldenstrom’s macroglobulinemia. We report a case of nephrotic syndrome and minimal change disease in a patient with biopsy proven Waldenstrom’s macroglobulinemia. The patient presented with over 12 grams of proteinuria and was successfully treated with oral prednisone over the course of 4 weeks. Repeat serum protein electrophoresis as well as serum immunoelectrophoresis revealed no paraproteins, urine analysis was negative for protein or blood by dipstick and spot urine protein was 9 mg/dL with creatinine of 101 mg/dL at time of last office visit. This case illustrates the successful treatment with corticosteroids alone with prolonged complete remission.

show abstract

“…La maladie est caractérisée par des dépôts d'immunoglobulines IgM kappa à la jonction dermoépidermique en immunohistochimie et en immunofluorescence directe. Ces dépôts pourraient jouer un rôle dans la formation des lésions bulleuses mais le mécanisme physiopathologique reste inconnu [31][32][33][34][35], même si l'on peut penser qu'un mécanisme proche de celui des dermatoses bulleuses auto-immunes de jonction puisse être impliqué.…”

Section: Dermatose Bulleuse à Igmunclassified

Manifestations dermatologiques des gammapathies monoclonales : apport de l’histopathologie cutanée

Lacoste¹,

Ingen‐Housz‐Oro

Ortonne³

2015

Annales de Pathologie

View full text Add to dashboard Cite

Waldenstrom macroglobulinemia with an IgM-kappa antiepidermal basement membrane zone antibody

Cited by 11 publications

References 0 publications

Immunobullous dermatosis associated with Waldenström macroglobulinaemia treated with rituximab

Immunobullous dermatosis associated with Waldenström macroglobulinaemia treated with rituximab

A Case of Nephrotic Syndrome With Minimal-Change Disease and Waldenstrom’s Macroglobulinemia

Manifestations dermatologiques des gammapathies monoclonales : apport de l’histopathologie cutanée

Contact Info

Product

Resources

About