JAMA
 2006
DOI: 10.1001/jama.296.10.1235
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Wait-and-See Prescription for the Treatment of Acute Otitis Media

David M. Spiro
1
,
Khoon-Yen Tay
2
,
Donald H. Arnold
3
et al.
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Cited by 243 publications

(137 citation statements)
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“…However, after 3 months, AOM recurrence was statistically higher in the control group. These findings were in coordination with some other studies [ 18 , 22 , 24 ]. Contrary to our findings, Hoberman et al's and Le Saux et al's studies reported that the recurrence rate of MEE and AOM were insignificantly higher in the control group after one month of treatment [ 19 , 21 ].…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, after 3 months, AOM recurrence was statistically higher in the control group. These findings were in coordination with some other studies [ 18 , 22 , 24 ]. Contrary to our findings, Hoberman et al's and Le Saux et al's studies reported that the recurrence rate of MEE and AOM were insignificantly higher in the control group after one month of treatment [ 19 , 21 ].…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In our study, we found a significant reduction in gastrointestinal adverse events for DAP and NAP compared to IAP, corroborating previous studies in which authors have evaluated DAP for RTIs in children. 19,20 Our findings are broadly similar to those of a previous trial in an adult population in Spain conducted by our group. 26 In that study, moderate and severe symptom durations were higher for DAP than for IAP but lower than for NAP, whereas in our study in children, symptom duration was slightly greater for DAP than for either IAP or NAP.…”
Section: Discussionsupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…We found differences in reported consumption rates for the various diagnoses, and the internal variation shows some resemblence with the results achieved in various diagnose-specific RCTs on delayed prescribing; 35% vs 24 - 38% (otitis media) [ 5 , 6 ], 46% vs 31% (sore throat) [ 7 ], 51% vs 20 - 45% (lower RTI/cough) [ 8 , 9 ], and 57% vs 48% (upper RTI/common cold) [ 10 ]. The results are understandably not directly comparable, as the methods of issuing delayed prescriptions differ between various studies, the diagnostic criteria varies, and the antibiotic prescription rates [ 3 ] and the patients' views on respiratory tract infections show great variance between countries [ 29 ].…”
Section: Discussionsupporting
confidence: 60%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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