Vulvovaginal Lichen Planus

Neill, Sallie; Lewis, Fiona M.

doi:10.1001/archderm.144.11.1502

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…Incidence and etiology have not been established. An association of vulvovaginal lesions and development of vulval intraepithelial neoplasia may exist, but remains controversial (Anderson et al, 2002, Neill and Lewis, 2008). Further, vulvovaginal LP may occasionally be referred to vulvovaginal-gingival syndrome as patients with vulvovaginal lesions often also have oral lesions, especially those affecting the gingival tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, several studies have suggested that steroid vaginal suppositories may be useful in controlling vulvovaginal LP lesions (Anderson et al, 2002, Sobel, 2002). Topical calcineurin inhibitors may be useful in some patients, but may increase risk of neoplastic transformation in genital tissue (Neill and Lewis, 2008). Other therapies reported anecdotally in the literature include cyclosporine, dapsone, griseofulvin, retinoid gel, thalidomide, antibiotics, hydroxychloroquine, and other immunosuppressive agents (Sobel, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Update on lichen planus and its clinical variants

Weston

Payette

2015

International Journal of Women's Dermatology

169

179

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Lichen planus (LP) is an inflammatory skin condition with characteristic clinical and histopathological findings. Classic LP typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist, including oral, nail, linear, annular, atrophic, hypertrophic, inverse, eruptive, bullous, ulcerative, lichen planus pigmentosus, lichen planopilaris, vulvovaginal, actinic, lichen planus-lupus erythematosus overlap syndrome, and lichen planus pemphigoides. Clinical presentation of the rarer variant lesions may be largely dissimilar to classic LP and therefore difficult to diagnose based solely on clinical examination. However, histopathological examination of LP and LP-variant lesions reveal similar features, aiding in the proper diagnosis of the disease. Management of LP and LP variants aims to control symptoms and to decrease time from onset to resolution; it often involves topical corticosteroids, but varies depending on the severity and location of the lesion. The literature contains an array of reports on the variations in presentation and successful management of LP and its variants. A familiarity with LP and its variants is important in achieving timely recognition and management of the disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Update on lichen planus and its clinical variants

Weston

Payette

2015

International Journal of Women's Dermatology

169

179

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“…1 The main sequelae are scar formation, mucous stenosis, impact on specific functions and risk of malignant change. 2 …”

Section: Discussionmentioning

confidence: 99%

Syndrome in question

Qiao

Fang

2014

An. Bras. Dermatol.

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“…Such disparate results confirm the fact that any association between the occurrences of lichen planus in the two mucosal sites could not be so straightforward as it initially seemed, since there may be great complexities and variations in factors responsible for the disease development and the way it manifests in the two anatomically distinct mucosal sites. Although our study was performed on a limited group of OLP women and yielded a low rate of but symptomatic genital involvement, considering even a very low possibility for the development of SCC in the background of GLP [8–12], a simple conclusion will advise the gynecologic examination preferably for the OLP women who complain from genital symptoms. However noting the asymptomatic cases in a considerable proportion of GLP patients in the other comparable studies [17–19], our study with its limitations and the small number of symptomatic GLP cannot reliably deny possible existence of symptomless cases of GLP in our community.…”

Section: Discussionmentioning

confidence: 99%

“…Various symptoms including burning, pain, vaginal discharge, and dyspareunia are frequent in patients with erythematous and erosive disease [3]. Moreover, there are the sequelae of vulval scarring and vaginal stenosis that affect sexual function [8], and may pose a small but definite risk of malignant change [8–12]. …”

Section: Introductionmentioning

confidence: 99%

Frequency of Genital Involvement in Women with Oral Lichen Planus in Southern Iran

Davarmanesh

Dehaghani

Deilami

et al. 2012

Dermatology Research and Practice

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Background. Lichen Planus is a chronic mucocutaneous disease of immunological basis and unknown etiology. women with oral lichen planus may have concomitant manifestations in vulvovaginal areas. Objective. To determine the frequency and risk factors of genital involvement in a group of Iranian women affected by oral lichen planus. Methods. Thirty-six women with clinical and histopathological diagnosis of oral lichen planus were evaluated for demographic, historical, and clinical parameters of the oral disease. All the patients were referred for careful vulvovaginal examination, as well as histopathological assessment upon clinical indication. Results. Nineteen patients complained from genital symptoms but the number of women with the final diagnosis of genital lichen planus (n = 2) was too small to show any correlation with the parameters evaluated. Conclusion. In spite of low genital involvement possibly due to inadequate patient population, lack of follow-up visits, and contribution of genetic or ethnic factors, for conservative patient care, women with the oral lichen planus in particular those having some relevant genital symptoms, should preferably be referred for careful vulvovaginal examination. Multicenter cohort studies on women of different geographical regions or ethnicities who have genital lichen planus alone or in combination with other common sites are encouraged.

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Vulvovaginal Lichen Planus

Cited by 13 publications

References 22 publications

Update on lichen planus and its clinical variants

Update on lichen planus and its clinical variants

Syndrome in question

Frequency of Genital Involvement in Women with Oral Lichen Planus in Southern Iran

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