Voxel-based morphometry in eating disorders: Correlation of psychopathology with grey matter volume

Joos, Andreas; Klöppel, Stefan; Hartmann, Armin; Glauche, Volkmar; Tüscher, Oliver; Perlov, Evgeniy; Saum, Barbara; Freyer, Tobias; Zeeck, Almut; Elst, Ludger Tebartz van

doi:10.1016/j.pscychresns.2010.02.004

Cited by 114 publications

(163 citation statements)

References 44 publications

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“…22 The precuneus, a core component of the DMN, plays an important role in these processes. 55 Altered precuneus activation has previously been observed in individuals with anorexia nervosa during self-image viewing, 33 and precuneus grey matter decreases have also been demonstrated in this population, 49 supporting the idea that this area contributes to core anorexia nervosa symptoms. 63 Serotonin 1A receptor activity has been shown to inversely predict DMN activation, 64 and increased serotonin 1A receptor availability has been associated with anorexia nervosa in ill, 65 but not recovered, individuals.…”

Section: Salience Networksupporting

confidence: 63%

“…As previous studies have found reduced grey matter volume in people with anorexia nervosa, 49 we analyzed structural data to test if group volumetric differences might have influenced functional differences (additional details are available in the Appendix).…”

Section: Behavioural and Structural Data Analysesmentioning

confidence: 99%

“…However, our finding of similarities in SN and differences in DMN activity between women with anorexia nervosa and recovered women may suggest biologic underpinnings that are not simply due to anorexia nervosa-related cognition. Differences in grey matter volume have also been demonstrated in individuals with anorexia nervosa, 49 which could contribute to functional differences. To assess this, we performed structural analyses and found no group differences in total grey or white matter volume or in total intracranial volume.…”

Section: Limitationsmentioning

confidence: 99%

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Reduced salience and default mode network activity in women with anorexia nervosa

McFadden

Tregellas

Shott

et al. 2014

J Psychiatry Neurosci

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Section: Salience Networksupporting

confidence: 63%

Section: Behavioural and Structural Data Analysesmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

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Reduced salience and default mode network activity in women with anorexia nervosa

McFadden

Tregellas

Shott

et al. 2014

J Psychiatry Neurosci

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“…The neural changes, cognitive impairments and low level motor impairments in eye‐movements that are found in low BMI women with AN as a result of malnutrition largely disappear with refeeding 22, 23, 24, 25. Thus, the fixation patterns displayed by the rAN group are unlikely to be due to cognitive impairment or their inability to move their gaze across the image as they would wish.…”

Section: Discussionmentioning

confidence: 96%

Fixation patterns, not clinical diagnosis, predict body size over‐estimation in eating disordered women and healthy controls

Cornelissen

Hancock

et al. 2016

Intl J Eating Disorders

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ObjectiveA core feature of anorexia nervosa (AN) is an over‐estimation of body size. Women with AN have a different pattern of eye‐movements when judging bodies, but it is unclear whether this is specific to their diagnosis or whether it is found in anyone over‐estimating body size.MethodTo address this question, we compared the eye movement patterns from three participant groups while they carried out a body size estimation task: (i) 20 women with recovering/recovered anorexia (rAN) who had concerns about body shape and weight and who over‐estimated body size, (ii) 20 healthy controls who had normative levels of concern about body shape and who estimated body size accurately (iii) 20 healthy controls who had normative levels of concern about body shape but who did over‐estimate body size.ResultsComparisons between the three groups showed that: (i) accurate body size estimators tended to look more in the waist region, and this was independent of clinical diagnosis; (ii) there is a pattern of looking at images of bodies, particularly viewing the upper parts of the torso and face, which is specific to participants with rAN but which is independent of accuracy in body size estimation.DiscussionSince the over‐estimating controls did not share the same body image concerns that women with rAN report, their over‐estimation cannot be explained by attitudinal concerns about body shape and weight. These results suggest that a distributed fixation pattern is associated with over‐estimation of body size and should be addressed in treatment programs. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:507–518).

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“…Also in the subjects affected with anorexia nervosa the anterior and posterior midline regions are also altered, both morphologically and functionally (Amianto et al, 2013a; Joos et al, 2010) [11,12]. As an adjunct,…”

mentioning

confidence: 99%

Neurobiological Correlates of Core Symptoms in Anorexia:Abnormal Spatiotemporal Structure in the Resting-StateActivity and Troubles of the Self

Amianto¹

2015

Acta Psychopathologica

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Voxel-based morphometry in eating disorders: Correlation of psychopathology with grey matter volume

Cited by 114 publications

References 44 publications

Reduced salience and default mode network activity in women with anorexia nervosa

Reduced salience and default mode network activity in women with anorexia nervosa

Fixation patterns, not clinical diagnosis, predict body size over‐estimation in eating disordered women and healthy controls

Neurobiological Correlates of Core Symptoms in Anorexia:Abnormal Spatiotemporal Structure in the Resting-StateActivity and Troubles of the Self

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