Voltammetric determination of Imatinib (Gleevec) and its main metabolite using square-wave and adsorptive stripping square-wave techniques in urine samples

Rodrı́guez, Juan F.; Berzas, J.J.; Castañeda, Gregorio; Rodríguez, Néstor

doi:10.1016/j.talanta.2004.11.010

Cited by 28 publications

(17 citation statements)

References 8 publications

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“…Furthermore, the present methods cover at least 4 orders of magnitude of SC concentration compared to only half- [5,6] to two- [2,8] decades of concentration obtained by voltammetry, spectrophotometry and HPLC [2][3][4][5][6]8]. On the other hand, the previously described potentiometric methods [18] suffers from narrower linear measurement range (10 )2 -10 )5 M), detection limit (5Â10 )6 M), longer response time (40 s), shorter life span (5 weeks) and significant interference by ions (Na + , K + , Mg 2+ , NH 4 + ) commonly present in high concentrations in biological fluids.…”

Section: Sc-pt Sc-rementioning

confidence: 95%

“…These include electrochemical oxidation on carbon electrodes [2], square-wave and adsorptive stripping square-wave voltammetry [3,4], flow injection analysis using UV-detection [5], extractive spectrophotometry based on the formation of ion-pair complexes of SC with bromocresol green and chromoxane cyanine-R dyes [6], liquid chromatography with detection at 230 nm [7], high performance liquid chromatography (HPLC) [8], and gas chromatography/mass spectrometry [9]. Most of these methods, however, utilize expensive instrumentation, suffer from lack of selectivity, involve careful control of the reaction conditions or derivatization reactions, and require time-consuming pretreatment steps which affect their usefulness for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

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Continuous potentiometric monitoring of viagra (sildenafil) in pharmaceutical preparations using novel membrane sensors

et al. 2005

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Two potentiometric sensors responsive to sildenafil citrate (SC) drug (the active component of viagra) are described, characterized, compared and used for drug assessment. The sensors are based on the use of the ion-association complexes of (SC) cation with tungstophosphate (TP) and reineckate (Re) anions as electroactive materials in plasticized poly(vinyl chloride) membranes. The sensors demonstrate fast near-Nernstian response for SC over the concentration ranges 1.0Â10 )2 -7.9Â10 )7 and 1.0Â10 )2 -1.0Â10 )6 M with detection limits of 0.53 and 0.67 lg ml )1 over pH 3-6 for TP and Re based membrane sensors, respectively. The sensors display good selectivity for SC drug over many nitrogeneous compounds, some inorganic cations and excipients and diluents commonly used in drug formulations. Validation of the assay methods with both sensors by measuring the lower detection limit, range, accuracy, precision, repeatability and between-day-variability reveals good performance characteristics confirming applicability for continuous determination of SC in pharmaceutical formulations and in spiked human serum. A membrane incorporating SC-TP complex in a tubular flow detector is used in a two channel flow injection set up for continuous monitoring of the drug at a frequency of 25-30 samples h )1 . The results obtained with drugs containing 50-100 mg SC tablet )1 show a mean standard deviation of ±2% of the nominal which agree fairly well with data obtained by spectrophotometry.

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Section: Sc-pt Sc-rementioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Continuous potentiometric monitoring of viagra (sildenafil) in pharmaceutical preparations using novel membrane sensors

et al. 2005

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“…The voltammetry used in the experiment of Hajian and Ensafi had three-electrodes containing hanging mercury drop electrode as a working electrode, a carbon rod as an auxiliary electrode and an Ag/AgCl (3.0 M KCl) reference electrode. This method was proved only on AFs B1 and B2, where both aflatoxins were found to adsorb and undergo irreversible reduction reaction at the working mercury electrode (Rodriguez et al, 2005). Adsorptive Stripping Voltammetry is an electrochemical method which has no or very low dependence on pH.…”

Section: Adsorptive Stripping Voltammetrymentioning

confidence: 99%

Methods for Detection and Quantification of Aflatoxins

Espinosa-Calderón¹,

Contreras-Medina²,

Muñoz-Huerta³

et al. 2011

Aflatoxins - Detection, Measurement and Control

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“…Berzas et al proposed the CE for the quantitative determination of FLX and NFLX by MEKC using as surfactant the compound 1-decanesulfonic acid sodium salt [27] and non-aqueous CE [28] was also used for its determination in urine sample. With respect to the analysis of saliva no determination by CE was found until now.…”

Section: Introductionmentioning

confidence: 99%

Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC

2009

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A micellar electrokinetic chromatographic method has been developed to analyze biological (human serum, saliva and urine) and environmental samples (three different water samples) for letrozole (LE), fluoxetine and their main metabolites. For this purpose a 20 mM borate buffer (pH 9.5) containing 20 mM SDS and 12% v:v 2-propanol was used as the background electrolyte. The samples were hydrodynamically injected for 6 s, separated in a fused-silica capillary at 25 kV and 50 degrees C and detected at 230 nm. Under these conditions, the migration times for all the studied compounds ranged from 3.0 up to 8.0 min. Linearity ranges were determined as 125-1500 ng/mL, whereas detection limits were from 37 to 120 ng/mL in biological samples and a value of 6 ng/mL in water samples. According to the validation study, the developed method was proved to be accurate, precise, sensitive, specific, rugged and robust. This method was applied to the analysis of different biological fluids at clinical levels, including two urine samples from patients undergoing treatment with LE or fluoxetine, and also to environmental samples at potentially polluting level. Prior to the determination, the samples were purified and pre-concentrated by means of an extraction-preconcentration step with a C18 cartridge and by eluting the compounds with methanol.

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Voltammetric determination of Imatinib (Gleevec) and its main metabolite using square-wave and adsorptive stripping square-wave techniques in urine samples

Cited by 28 publications

References 8 publications

Continuous potentiometric monitoring of viagra (sildenafil) in pharmaceutical preparations using novel membrane sensors

Continuous potentiometric monitoring of viagra (sildenafil) in pharmaceutical preparations using novel membrane sensors

Methods for Detection and Quantification of Aflatoxins

Rapid quantitative analysis of letrozole, fluoxetine and their metabolites in biological and environmental samples by MEKC

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