Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections

Qader, Amir Abd El; Lieberman, David; Avni, Yonat Shemer; Svobodin, Natali; Lazarovitch, Tsilia; Sagi, Orli; Zeiri, Yehuda

doi:10.1002/bmc.3494

Cited by 53 publications

(53 citation statements)

References 24 publications

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“…The factor analysis identified one factor consisting of cyclohexane, methylcyclohexane and benzaldehyde. Methylcyclohexane is found in consumer products (Sack and Steele, 1992) but can also be emitted from pathogenic bacteria associated with respiratory infections (Abd El Qader et al, 2015). In the large European AIRMEX study, the mean indoor levels of methylcyclohexane in public buildings/schools was the same as in our study (2.9 μg/m 3 ) but the outdoor levels were much lower (0.4 μg/m 3 ) (Geiss et al, 2011).…”

Section: Discussionsupporting

confidence: 55%

Volatile organic compounds (VOC), formaldehyde and nitrogen dioxide (NO 2 ) in schools in Johor Bahru, Malaysia: Associations with rhinitis, ocular, throat and dermal symptoms, headache and fatigue

Norbäck

Hashim

et al. 2017

Science of The Total Environment

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• Xylene, formaldehyde and NO 2 in schools in Malaysia can be associated with fatigue among students.• Formaldehyde and NO 2 in the classrooms can be associated with ocular symptoms.• The indoor and outdoor levels of benzene were often above the EU standard for ambient air. This paper studied associations between volatile organic compounds (VOC), formaldehyde, nitrogen dioxide (NO 2 ) and carbon dioxide (CO 2 ) in schools in Malaysia and rhinitis, ocular, nasal and dermal symptoms, headache and fatigue among students. Pupils from eight randomly selected junior high schools in Johor Bahru, Malaysia (N = 462), participated (96%). VOC, formaldehyde and NO 2 were measured by diffusion sampling (one week) and VOC also by pumped air sampling during class. Associations were calculated by multi-level logistic regression adjusting for personal factors, the home environment and microbial compounds in the school dust. The prevalence of weekly rhinitis, ocular, throat and dermal symptoms were 18.8%, 11.6%, 15.6%, and 11.1%, respectively. Totally 20.6% had weekly headache and 22.1% fatigue. Indoor CO 2 were low (range 380-690 ppm). Indoor median NO 2 and formaldehyde concentrations over one week were 23 μg/m 3 and 2.0 μg/m G R A P H I C A L A B S T R A C T a b s t r a c t a r t i c l e i n f o Contents lists available at ScienceDirectScience of the Total Environment j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / s c i t o t e n v in schools can be risk factors for ocular and throat symptoms and fatigue among students in Malaysia. The indoor and outdoor levels of benzene were often higher than the EU standard of 5 μg/m 3 .

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Section: Discussionsupporting

confidence: 55%

Volatile organic compounds (VOC), formaldehyde and nitrogen dioxide (NO 2 ) in schools in Johor Bahru, Malaysia: Associations with rhinitis, ocular, throat and dermal symptoms, headache and fatigue

Norbäck

Hashim

et al. 2017

Science of The Total Environment

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“…Aksenov et al ( 8 ) determined that VOC produced by B lymphoblastoid cells following infection with three live influenza virus subtypes were unique for each virus subtype. In addition, Abd El Qader et al ( 9 ) examined the VOC released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus, and parainfluenza 1 virus) and four bacteria ( Moraxella catarrhalis , Haemophilus influenza , Legionella pneumophila , and Mycoplasma pneumoniae ). The researchers detected 12 and 6 VOC that were associated with bacterial and viral growth and identified 2 VOC that were differentiated between bacterial and viral infection ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Abd El Qader et al ( 9 ) examined the VOC released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus, and parainfluenza 1 virus) and four bacteria ( Moraxella catarrhalis , Haemophilus influenza , Legionella pneumophila , and Mycoplasma pneumoniae ). The researchers detected 12 and 6 VOC that were associated with bacterial and viral growth and identified 2 VOC that were differentiated between bacterial and viral infection ( 9 ). Lastly, Mashir et al ( 10 ) administered live attenuated H1N1 vaccine (FluMist ® ) to humans and demonstrated that exhaled breath VOC increased for 7 days after the vaccination.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Detection of a Virus Using Detection Dogs

et al. 2016

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Viral infections are ubiquitous in humans, animals, and plants. Real-time methods to identify viral infections are limited and do not exist for use in harsh or resource-constrained environments. Previous research identified that tissues produce unique volatile organic compounds (VOC) and demonstrated that VOC concentrations change during pathologic states, including infection, neoplasia, or metabolic disease. Patterns of VOC expression may be pathogen specific and may be associated with an odor that could be used for disease detection. We investigated the ability of two trained dogs to detect cell cultures infected with bovine viral diarrhea virus (BVDV) and to discriminate BVDV-infected cell cultures from uninfected cell cultures and from cell cultures infected with bovine herpes virus 1 (BHV 1) and bovine parainfluenza virus 3 (BPIV 3). Dogs were trained to recognize cell cultures infected with two different biotypes of BVDV propagated in Madin–Darby bovine kidney cells using one of three culture media. For detection trials, one target and seven distractors were presented on a scent wheel by a dog handler unaware of the location of targets and distractors. Detection of BVDV-infected cell cultures by Dog 1 had a diagnostic sensitivity of 0.850 (95% CI: 0.701–0.942), which was lower than Dog 2 (0.967, 95% CI: 0.837–0.994). Both dogs exhibited very high diagnostic specificity (0.981, 95% CI: 0.960–0.993) and (0.993, 95% CI: 0.975–0.999), respectively. These findings demonstrate that trained dogs can differentiate between cultured cells infected with BVDV, BHV1, and BPIV3 and are a realistic real-time mobile pathogen sensing technology for viral pathogens. The ability to discriminate between target and distractor samples plausibly results from expression of unique VOC patterns in virus-infected and -uninfected cells.

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“…The human body produces volatile organic compounds (VOCs) either physiologically or pathologically [7][8][9]. The identification of VOCs associated with specific pathological states and their use as potential biomarkers [10] is highly complex.…”

Section: Introductionmentioning

confidence: 99%

A New Transcutaneous Method for Breast Cancer Detection with Dogs

Thuleau¹,

Gilbert²,

Bauër³

et al. 2018

Oncology

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We developed a new transcutaneous method for breast cancer detection with dogs: 2 dogs were trained to sniff skin secretion samples on compresses that had been worn overnight by women on their breast, and to recognize a breast cancer sample among 4 samples. During the test, the dogs recognized 90.3% of skin secretion breast cancer samples. This proof-of-concept study opens new avenues for the development of a reliable cancer diagnostic tool integrating olfactory abilities of dogs.

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Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections

Cited by 53 publications

References 24 publications

Volatile organic compounds (VOC), formaldehyde and nitrogen dioxide (NO 2 ) in schools in Johor Bahru, Malaysia: Associations with rhinitis, ocular, throat and dermal symptoms, headache and fatigue

Volatile organic compounds (VOC), formaldehyde and nitrogen dioxide (NO 2 ) in schools in Johor Bahru, Malaysia: Associations with rhinitis, ocular, throat and dermal symptoms, headache and fatigue

Real-Time Detection of a Virus Using Detection Dogs

A New Transcutaneous Method for Breast Cancer Detection with Dogs

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