Voice Quality in Short Stature With and Without GH Deficiency

Valença, Eugênia H O; Souza, Anita H. O.; Oliveira, Alaíde H.A.; Valença, Silvio Leonardo; Salvatori, Roberto; Gonçalves, Maria Inês Rebelo; Oliveira-Neto, Luiz A.; Barros, Alana Dantas; Nascimento, Ualisson Nogueira do; Oliveira, Carla R. P.; Cardoso, Daniela; Melo, Valdinaldo Aragão de; Aguiar‐Oliveira, Manuel H.

doi:10.1016/j.jvoice.2011.12.009

Cited by 21 publications

(19 citation statements)

References 30 publications

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“…In addition, in this subgroup we found a reduction in the duration of N3 in IGHD compared to controls, suggesting an additional effect of aging to GHRH receptor deficiency in this model. Interestingly, sleep, as skin ovary, and hearing seems to get older faster in IGHD than controls 51,52 , in contrast to bones, voice and blood vessels [53][54][55] .…”

Section: Discussionmentioning

confidence: 99%

Altered sleep patterns in patients with non-functional GHRH receptor

Oliveira

Salvatori

Marcondes³

et al. 2017

European Journal of Endocrinology

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Section: Discussionmentioning

confidence: 99%

Altered sleep patterns in patients with non-functional GHRH receptor

Oliveira

Salvatori

Marcondes³

et al. 2017

European Journal of Endocrinology

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“…3) (61). These cephalometric features may help the diagnosis of IGHD, and -together with the underdevelopment of the larynx -lead to a typically highpitched voice with high fundamental frequency in both genders (62,63). Formal voice analysis showed higher values of most formant frequencies, suggesting smaller oral and pharyngeal cavities.…”

Section: Bone Growth and Structurementioning

confidence: 91%

“…The voice changes result in a reduction of the effect of gender on the structure of the formants, maintaining a pre-pubertal acoustic prediction (64). Therefore, GH plays a relevant role in the development of voice quality, mostly increasing vocal cords thickness (62,63,64).…”

Section: Bone Growth and Structurementioning

confidence: 99%

“…These features have been published in 42 different publications (2,19,22,25,27,29,30,31,32,33,36,37,38,40,41,44,45,46,47,48,49,50,51,52,53,54,56,57,61,62,63,64,66,67,68,74,75,76,77,78,79,80). We have used this experiment of nature to discover 'usual laws of nature' as suggested by William Harvey, and to understand some aspects of more common conditions such as short stature, insulin resistance, diabetes, atherosclerosis, osteoporosis, cancer and ultimately longevity.…”

Section: Introductionmentioning

confidence: 99%

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MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation

Aguiar‐Oliveira

Souza

Oliveira

et al. 2017

European Journal of Endocrinology

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Twenty years ago, we described kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in northeast Brazil, carrying a homozygous mutation in the GH-releasing hormone receptor gene. These subjects exhibit markedly reduced GH responsiveness to stimulatory tests, and anterior pituitary hypoplasia. Serum concentrations of IGF-I, IGF binding protein type 3 and the acid-labile subunit are markedly reduced, with a lesser reduction of IGF-II. The most striking physical findings of these IGHD individuals are the proportionate short stature, doll facies, high-pitched voice and visceral obesity with reduced fat-free mass. There is neither microphallus, nor neonatal hypoglycemia. Puberty is delayed, menopause anticipated, but fertility is preserved in both genders. The reduction in bone sizes is not even, with mean standard deviation scores for height of −7.2, total maxillary length of −6.5, total facial height of −4.3 and cephalic perimeter of −2.7. In addition, the non-osseous growth is not uniform, preserving some organs, like pancreas, liver, kidney, brain and eyes, and compromising others such as thyroid, heart, uterus and spleen. These subjects present higher prevalence of dizziness, mild high-tones sensorineural hearing loss, reduction of vascular retinal branching points, increase of optic disk, genu valgum and increased systolic blood pressure. Biochemically, they have high low density lipoprotein cholesterol and C-reactive protein levels, but maintain increased insulin sensitivity, and do not show premature atherosclerosis. Finally, they have normal immune function, and normal longevity. This review details the findings and summarizes 20 years of clinical research carried out in this unique population.

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“…Patients with GHD have reduced vocal perception, higher prevalence of laryngopharyngeal reflux, laryngeal constriction with a high pitch, and poor voice-related quality of life. [ 14 15 ]…”

Section: Oice and P Ituitary mentioning

confidence: 99%

Voice and endocrinology

Kumar

Garg

et al. 2016

Indian J Endocr Metab

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Voice is one of the advanced features of natural evolution that differentiates human beings from other primates. The human voice is capable of conveying the thoughts into spoken words along with a subtle emotion to the tone. This extraordinary character of the voice in expressing multiple emotions is the gift of God to the human beings and helps in effective interpersonal communication. Voice generation involves close interaction between cerebral signals and the peripheral apparatus consisting of the larynx, vocal cords, and trachea. The human voice is susceptible to the hormonal changes throughout life right from the puberty until senescence. Thyroid, gonadal and growth hormones have tremendous impact on the structure and function of the vocal apparatus. The alteration of voice is observed even in physiological states such as puberty and menstruation. Astute clinical observers make out the changes in the voice and refer the patients for endocrine evaluation. In this review, we shall discuss the hormonal influence on the voice apparatus in normal and endocrine disorders.

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Voice Quality in Short Stature With and Without GH Deficiency

Cited by 21 publications

References 30 publications

Altered sleep patterns in patients with non-functional GHRH receptor

Altered sleep patterns in patients with non-functional GHRH receptor

MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation

Voice and endocrinology

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