Vitiligo treatment with a combination of PUVA therapy and epidermal autografts

Skouge, J.

doi:10.1001/archderm.131.11.1257

Cited by 14 publications

(6 citation statements)

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“…Full-thickness punch grafts and suction blister grafts are recommended for localized and segmental vitiligo lesions [1, 3, 13]. With full-thickness punch grafts the palms and soles can be treated as well [1].…”

Section: Discussionmentioning

confidence: 99%

“…The machine consists of a vacuum pump connected to two suction cylinders by a flexible tube. A combination of negative pressure and heat produces blisters in 30–60 min [3]. No anaesthesia is required for this procedure.…”

Section: Procedures For Harvesting Donor Skinmentioning

confidence: 99%

“…All surgical techniques (table 1) have the same basic principle: to transplant autologous melanocytes from a pigmented donor skin to regions without melanocytes [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]. Although this is theoretically possible in all patients with a pigmented donor area, some prerequisites are necessary for vitiligo patients to be eligible for transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Techniques for Vitiligo: A Review

Geel

Ongenae

Naeyaert³

2001

Dermatology

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Although the treatment of vitiligo has improved during the last decade, therapy is still not satisfying for many patients. This is probably due to the fact that the aetiopathogenesis is unknown. Several treatment modalities, such as PUVA, UVB and local corticosteroids are currently used in the treatment of active vitiligo. However, these treatments usually induce incomplete repigmentation. Surgical methods intended to repigment leucoderma are an interesting therapeutic option if patients have stable disease. Two types of surgical techniques are available: tissue grafts and cellular grafts, with in between autologous cultured epithelial grafts. Tissue grafts are full-thickness punch grafts, split-thickness grafts and suction blister grafts. With tissue grafts, only a limited surface area can be treated but with good results in the majority of cases. Cellular grafts include non-cultured keratinocytes/melanocytes and cultured melanocytes. The exact success rate of repigmentation with cellular grafts is still unknown, since only a small number of studies have been published. Starting from autologous cellular suspensions, epithelial grafts of various compositions can be cultured in vitro. They can be used for larger areas. The purpose of this review is to describe the applications of different surgical techniques used to treat recalcitrant vitiligo.

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Section: Discussionmentioning

confidence: 99%

Section: Procedures For Harvesting Donor Skinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical Techniques for Vitiligo: A Review

Geel

Ongenae

Naeyaert³

2001

Dermatology

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“…These include measuring collagen propeptides in scleroderma patients, 9 harvesting Langerhans cells for immunologic analysis, 10,11 and obtaining epidermal autografts for treatment of vitiligo, 12 to list a few. In this study, we recommend its use as an in vivo model for wound regeneration in humans.…”

Section: Discussionmentioning

confidence: 99%

Reassessment of the suction blister model of wound healing: introduction of a new higher pressure device

Alexis¹

1999

Int J Dermatol

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“…Previous studies have reported that the combination of epithelial grafting and psoralen plus UVA may speed up repigmentation, [11][12][13] with some starting phototherapy as early as immediately postgrafting. The most recent European Dermatology Forum consensus guidelines on vitiligo recommended that when a surgical treatment is conducted in nonsegmental vitiligo, it should be combined with UV light treatment for best outcome and long-term stability.…”

Section: In 2005mentioning

confidence: 99%