Vitiligo treated with topical clobetasol propionate

Kumari, J.

doi:10.1001/archderm.120.5.631

Cited by 46 publications

(46 citation statements)

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“…Considering the effectiveness of topical corticosteroids according to current data in vitiligo, betamethasone valerate cream as class III corticosteroid, was given to all patients. [192324]…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo Patients

et al. 2017

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Background:Vitiligo, a common disorder of depigmentation, is often difficult to treat. Corticosteroids are known to be effective, but with modest results. Although simvastatin has been reported to be effective for immunorelated dermatologic disorders including vitiligo, controlled trials are lacking. This study was conducted to compare the efficacy of topical betamethasone valerate 0.1% cream (as a standard method of treatment for vitiligo) versus a combination of betamethasone valerate plus oral simvastatin in the treatment of vitiligo.Materials and Methods:Eighty-eight subjects with symmetric vitiligo who had body surface involvement up to 20% were divided randomly into two groups. Group A were treated with betamethasone valerate 01% cream twice daily and Group B with betamethasone valerate 01% cream twice daily and oral simvastatin 80 mg daily for 12 weeks. Finally, 46 patients completed treatment after 12 weeks in both groups. The results were evaluated by a blind dermatologist using Vitiligo Area Scoring Index (VASI) score at baseline, 4th, 8th, and 12th week of treatment. In a similar way, subjective assessment performed by patients based on photo evaluation at the end of the study.Results:Despite a continuous reduction in VASI score in both groups, according to both physician (P = 0.13) and patient (P = 0.374) assessment oral simvastatin was not statistically more effective than conventional treatment of vitiligo.Conclusion:This study indicates that oral simvastatin is not associated with significant impacts in the treatment of vitiligo as compared to other inflammatory dermatologic conditions such as psoriasis. Indeed, other studies should be initiated regarding exact molecular and cellular effects of statins in the treatment of vitiligo.

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Section: Discussionmentioning

confidence: 99%

A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo Patients

et al. 2017

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“…12 Higher response rates are seen in children compared to adults 2 ; head and neck lesions tend to have the greatest response to treatment. 2,3 In a review of 101 children treated with topical CSs alone, Kwinter et al 13 reported response rates of 64%. Complete repigmentation rates have been reported to be as high as 49.3%.…”

Section: Efficacy Of Topical Corticosteroidsmentioning

confidence: 99%

Vitiligo: A comprehensive overview

Felsten

Alikhan

Petronic‐Rosic

2011

Journal of the American Academy of Dermatology

151

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“…Topical corticosteroids have the best results (75% of repigmentation) on sun-exposed areas (face and neck), (82,83) in dark skin, (84) in recent lesions (85) and in children compared to adults (86) …”

Section: Topical Corticosteroidsmentioning

confidence: 99%

Concise review of recent studies in vitiligo

Allam

Riad

2014

Qatar Medical Journal

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Vitiligo is an acquired pigmentry disorder of the skin and mucous membranes which manifests as white macules and patches due to selective loss of melanocytes. Etiological hypotheses of vitiligo include genetic, immunological, neurohormonal, cytotoxic, biochemical, oxidative stress and newer theories of melanocytorrhagy and decreased melanocytes survival. There are several types of vitiligo which are usually diagnosed clinically and by using a Wood's lamp; also vitiligo may be associated with autoimmune diseases, audiological and ophthalmological findings or it can be a part of polyendocrinopathy syndromes. Several interventions are available for the treatment for vitiligo to stop disease progression and/or to attain repigmentation or even depigmentation. In this article, we will present an overall view of current standing of vitiligo research work especially in the etiological factors most notably the genetic components, also, types and associations and various and newer treatment modalities.

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Vitiligo treated with topical clobetasol propionate

Cited by 46 publications

References 0 publications

A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo Patients

A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the Treatment of Vitiligo Patients

Vitiligo: A comprehensive overview

Concise review of recent studies in vitiligo

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