2014
DOI: 10.1590/abd1806-4841.20142717
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Vitiligo - Part 2 - classification, histopathology and treatment

Abstract: In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes. Physical and pharmacological treatment strategies aim to control the autoimmune damage and stimulate melanocyte migration from the unaffected edges of le… Show more

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Cited by 67 publications
(62 citation statements)
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References 52 publications
(50 reference statements)
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“…In vitiligo, biopsy will demonstrate in the center of a lesion the loss of melanocytes (pigment cells) with special stains of the epidermis. The border of a lesion may be noted visually to be inflamed (inflammatory vitiligo), and a notable inflammatory infiltrate of CD 4+ and CD 8+ T lymphocytes may be seen on biopsy of an "active" border, 39 although the inflammation may be clinically absent.…”
Section: Diagnosis and Differential Diagnosismentioning
confidence: 99%
“…In vitiligo, biopsy will demonstrate in the center of a lesion the loss of melanocytes (pigment cells) with special stains of the epidermis. The border of a lesion may be noted visually to be inflamed (inflammatory vitiligo), and a notable inflammatory infiltrate of CD 4+ and CD 8+ T lymphocytes may be seen on biopsy of an "active" border, 39 although the inflammation may be clinically absent.…”
Section: Diagnosis and Differential Diagnosismentioning
confidence: 99%
“…Treatment of vitiligo includes pharmacological, physical, and surgical approaches or a combination of different procedures (Faria, Tarlé, Dellatorre, Mira, & Castro, ).…”
Section: Introductionmentioning
confidence: 99%
“…There may be a relationship between vitiligo and stress, because psychological stress can increase levels of neuroendocrine hormones, leading to a damage of melanocytes of the skin (Al'Abadie et al, 1994). Recently, excimer laser and surgical treatment have been used in some types of vitiligo, but not widely because they are painful, expensive, and not successful for all patients (Faria et al, 2014).…”
Section: Introductionmentioning
confidence: 99%