Vitiligo is not a cosmetic disease

Ezzedine, Khaled; Sheth, Vaneeta M.; Rodrigues, Michelle; Eleftheriadou, Viktoria; Harris, John E.; Hamzavi, Iltefat; Pandya, Amit G.

doi:10.1016/j.jaad.2015.07.039

Cited by 99 publications

(87 citation statements)

References 22 publications

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“…On the contrary, vitiligo is a chronic skin condition characterized by portions of the skin losing their pigment when skin pigment cells die or are unable to function [28,29]: the surrounding unaffected skin may be lightened to match to the tone of the affected skin.…”

Section: Why Such a Practice?mentioning

confidence: 99%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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Abstract:With the public's growing interest in skin whitening, lightening ingredients only used under dermatological supervision until recently, are more and more frequently incorporated into cosmetic formulas. The active agents that lighten skin tone are either natural or synthetic substances, and may act at various levels of melanogenesis. They are used to treat various skin pigmentation disorders or simply to obtain a lighter skin tone as whiter skin may be synonymous of wealth, health, youth, and/or beauty in different cultures. However, recent studies demonstrated the adverse effects of some of these ingredients, leading to their interdiction or restricted use under the European Directive and several other international regulations. After an overview of skin whitening practices and the associated risks, this article provides insight into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients. The legislation dealing with the use of skin lighteners is then discussed. As traditional depigmenting agents such as hydroquinone and corticosteroids are of safety concern, the potential of natural extracts has been investigated more and more; finally, a synthesis of three years of research in our laboratory for such plant extracts will be given.

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Section: Why Such a Practice?mentioning

confidence: 99%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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“…Moreover, patients often complain that physicians are unaware of treatment options and that most of these physicians consider vitiligo as a "cosmetic disease." 5 Despite the lack of demonstrative physical symptoms accompanying the disease as compared with other common chronic dermatological disorders, such as eczema and psoriasis, vitiligo causes emotional distress and impairs patient and parental quality of life in childhood.…”

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confidence: 99%

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

Ezzedine

Silverberg

2016

Pediatrics

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Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childhood onset, needing thus a treatment approach that will minimize treatment side effects while avoiding psychological impacts. Management of vitiligo should take into account several factors, including extension, psychological impact, and possible associations with other autoimmune diseases. This review discusses the epidemiology of vitiligo and outlines the various clinical presentations associated with the disorder and their differential diagnosis. In addition, the pathophysiology and genetic determinants, the psychological impact of vitiligo, and management strategies are reviewed.

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“…Death of melanocytes leads to the appearance of patchy depigmentation of the skin. Vitiligo affects roughly 1% of the population and is a severely disfiguring disease that impacts patients’ quality of life and self‐esteem (Alikhan, Felsten, Daly, & Petronic‐Rosic, ; Ezzedine et al., ; Harris, ; Picardo et al., ; Taïeb & Picardo, ). Patients may also develop numerous adverse effects from vitiligo and its systemic associations.…”

Section: Commentarymentioning

confidence: 99%

Mouse Model for Human Vitiligo

2018

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Vitiligo is an autoimmune skin disease in which the pigment‐producing melanocytes are destroyed by autoreactive CD8+ T cells. As a result, patients develop disfiguring white spots on the skin. This article discusses the first mouse model of vitiligo that develops epidermal depigmentation, similar to disease in human patients. To achieve epidermal depigmentation, mice are genetically engineered to retain melanocytes in the skin epidermis. Induction of disease occurs by adoptive transfer of melanocyte‐specific CD8+ T cells into recipient mice and the subsequent activation of these T cells using a viral vector. Depigmentation of the epidermis occurs within 5 to 7 weeks in a patchy pattern similar to patients with vitiligo. This article describes the methods of vitiligo induction, quantification of lesion progression and regression, processing of the skin for detailed analysis, and how to use this model to inform clinical studies. © 2018 by John Wiley & Sons, Inc.

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Vitiligo is not a cosmetic disease

Cited by 99 publications

References 22 publications

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

Mouse Model for Human Vitiligo

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