Vitiligo in (Apparent) Dermatomal Distribution

Scholtz, Jud R.

doi:10.1001/archderm.1951.01570090113017

Cited by 21 publications

(5 citation statements)

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“…Recent experimental evidence provide proof-of-concept showing that, in mouse models, acute stress leads to hair graying via a mechanism that involves exhaustion of melanocyte stem cells [12,74]. Dermatomes, which are specific regions of skin innervated by a single spinal nerve, have been implicated in focal dysregulation of hair pigmentation (e.g., in segmental vitiligo [76,77]).…”

Section: Mechanisms For Hair Graying: Neuronal Regulationmentioning

confidence: 99%

Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

Ungvari,

Kiss,

Gulej

et al. 2024

GeroScience

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Hair graying, also known as canities or achromotrichia, is a natural phenomenon associated with aging and is influenced by external factors such as stress, environmental toxicants, and radiation exposure. Understanding the mechanisms underlying hair graying is an ideal approach for developing interventions to prevent or reverse age-related changes in regenerative tissues. Hair graying induced by ionizing radiation (γ-rays or X-rays) has emerged as a valuable experimental model to investigate the molecular pathways involved in this process. In this review, we examine the existing evidence on radiation-induced hair graying, with a particular focus on the potential role of radiation-induced cellular senescence. We explore the current understanding of hair graying in aging, delve into the underlying mechanisms, and highlight the unique advantages of using ionizing-irradiation–induced hair graying as a research model. By elucidating the molecular pathways involved, we aim to deepen our understanding of hair graying and potentially identify novel therapeutic targets to address this age-related phenotypic change.

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Section: Mechanisms For Hair Graying: Neuronal Regulationmentioning

confidence: 99%

Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

Ungvari,

Kiss,

Gulej

et al. 2024

GeroScience

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“…The hypothesis that innervation influences depigmentation, often labeled the "neural hypothesis", is primarily based on a few largely unsupported observations: 1) Segmental vitiligo is unilateral, and therefore mistakenly labeled as dermatomal; however, disease is rarely limited to a single dermatome, and often crosses many dermatomes (11,(16)(17)(18). 2) Lerner hypothesized that vitiligo is caused by the increase of neuropeptides released by neurons and that this decreases melanocyte melanin production (19).…”

Section: Neural Theorymentioning

confidence: 99%

Translational Research in Vitiligo

Katz

Harris

2021

Front. Immunol.

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Vitiligo is a disease of the skin characterized by the appearance of white spots. Significant progress has been made in understanding vitiligo pathogenesis over the past 30 years, but only through perseverance, collaboration, and open-minded discussion. Early hypotheses considered roles for innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics. Because theories about pathogenesis drive experimental design, focus, and even therapeutic approach, it is important to consider their impact on our current understanding about vitiligo. Animal models allow researchers to perform mechanistic studies, and the development of improved patient sample collection methods provides a platform for translational studies in vitiligo that can also be applied to understand other autoimmune diseases that are more difficult to study in human samples. Here we discuss the history of vitiligo translational research, recent advances, and their implications for new treatment approaches.

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“…Additional skin diseases that may appear as zosteriform pattern include zosteriform perforating collagenosis, unilateral nevoid telangiectasia, zosteriform nevus spilus with melanoma, transient acantholytic dermatosis, progressive cribriform and zosteriform hyperpigmentation, Spitz nevi, epitheloid hemangioma, porokeratosis zosteriform nevus spilus, arterio-venous malformations, and segmental vitiligo may also present with a zosteriform pattern [84][85][86][87][88][89][90][91][92][93][94][95][96][97][98]. Although there is another publication about segmental vitiligo being a misnomer and rather than a dermatomal distributed disease it may be results from cutaneous mosaism [99].…”

Section: Other Skin Diseasesmentioning

confidence: 99%