Vitiligo and juvenile diabetes mellitus

Abstract

Five juvenile diabetics had vitiligo. In two children, the vitiligo preceded the onset of diabetes. Four of the five patients had thyroid, adrenal, or gastric antibodies or a combination of these. In three children HLA-B8 antigens were detected, and one additional patient had HLA-Bw15. Of eight nondiabetic children with vitiligo, one had abnormal glucose tolerance. To the evidence supporting an autoimmune form of diabetes mellitus we add another observation: the association of insulin-dependent diabetes and childhood vitiligo.

Association between vitiligo and relevant components of metabolic syndrome: a systematic review and meta‐analysis

“…The prevalence of diabetes mellitus in vitiligo patients was reported from 24 studies, including ten case‐control studies and 14 cross‐sectional studies [19–42]. The meta‐analysis illustrated that the prevalence of diabetes mellitus was 2.0 % in vitiligo patients (95 % CI, 1.0 %–2.0 %; P = 0.000) (Figure 4a).…”

“…Given the considerable heterogeneity among the 24 studies on vitiligo and diabetes mellitus included in our meta‐analysis [19–42], subgroup analysis was conducted. Potentially distorting factors including ethnicity and study design were taken into consideration for the subgroup analysis.…”

“…The ethnicities across included studies covered European (3 studies) [20, 27, 30], Asian (17 studies) [19, 21, 23–26, 28, 31–34, 36, 38–40, 42], American (3 studies) [22, 29, 37] and African (1 study) [41]. Ethnical subgroup analysis was performed on the three ethnicities with multiple studies, with African not included because only one relevant study was obtained.…”

“…As shown in Figure 6, despite the moderate heterogeneity in the European population, a high heterogeneity was observed in Asian ( I 2 = 92.4 %; P = 0.000) and American ( I 2 = 80.8 %; P = 0.006). As for study design, case‐control study (10 studies) [19, 20, 23, 27, 30, 31, 35, 36, 38, 39] and cross‐sectional study (14 studies) [21, 22, 24–26, 28, 29, 32–34, 37, 40–42] were classified, and a high heterogeneity was again determined in each subgroup (Figure 7). Therefore, ethnicity and the type of study design were not the source of heterogeneity in our meta‐analysis on the association of vitiligo with diabetes mellitus.…”

“…Among the 24 studies that reported the prevalence of diabetes mellitus in vitiligo patients [19–42], Begg’s test indicated that there was no statistically significant publication bias ( P = 0.102).…”