1977
DOI: 10.1001/archderm.113.11.1515
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Vitiligo and juvenile diabetes mellitus

Abstract: Five juvenile diabetics had vitiligo. In two children, the vitiligo preceded the onset of diabetes. Four of the five patients had thyroid, adrenal, or gastric antibodies or a combination of these. In three children HLA-B8 antigens were detected, and one additional patient had HLA-Bw15. Of eight nondiabetic children with vitiligo, one had abnormal glucose tolerance. To the evidence supporting an autoimmune form of diabetes mellitus we add another observation: the association of insulin-dependent diabetes and ch… Show more

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Cited by 22 publications
(28 citation statements)
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“…12A,B) consists of diffuse velvety thickening and hyperpigmentation of the skin, chiefly in the axillae, neck, inframammary folds, groin, perineum, and, less often, nipples and areolae. 80 Vitiligo occurs with greater than expected incidence in patients with diabetes, either type 1 81 or type 2. 82 Diabetic dermopathy consists of asymptomatic, irregularly shaped patches occurring on the anterior lower legs; their surfaces are depressed and they have a light‐brown color.…”
Section: Diabetes Mellitusmentioning
confidence: 99%
“…12A,B) consists of diffuse velvety thickening and hyperpigmentation of the skin, chiefly in the axillae, neck, inframammary folds, groin, perineum, and, less often, nipples and areolae. 80 Vitiligo occurs with greater than expected incidence in patients with diabetes, either type 1 81 or type 2. 82 Diabetic dermopathy consists of asymptomatic, irregularly shaped patches occurring on the anterior lower legs; their surfaces are depressed and they have a light‐brown color.…”
Section: Diabetes Mellitusmentioning
confidence: 99%
“…The autoimmune hypothesis has been supported by experimental data and by the clinical association with other autoimmune diseases, in particular thyroiditis [10, 11, 12, 13]. …”
Section: Introductionmentioning
confidence: 99%
“…Other studies have reported the association of vitiligo with Numerous cutaneous and systemic disorders like diabetes mellitus. 15,16 In some of these conditions, such as the autoimmune diseases, the incidence of vitiligo is significantly higher than in the population at large. This study was done in small population in a center, a robust study with community sampling would reveal the true nature of thyroid disorder in vitiligo patients.…”
Section: Discussionmentioning
confidence: 99%