Vitiligo and autoimmune polyendocrine deficiencies with autoantibodies to melanin-producing cells

Betterle, Corrado

doi:10.1001/archderm.115.3.364

Cited by 15 publications

(7 citation statements)

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“…parathyroid (PA), islet cell (ICA), adrenal (AA), glucagon cell (GCA), somatostatin cell (SCA), melanocyte (MA), antinuclear (ANA), smooth muscle (SMA) and antimitochondrial (AMA) autoan tibodies using indirect immunofluorescence techniques on normal human and animal tissues [4][5][6][7][8]. Thyroglobulin autoantibodies (TgHA) were detected by tanned red cell agglutination with a commercial kit (Wellcome, Beckenham, UK).…”

Section: Methodsmentioning

confidence: 99%

Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo

Betterle

Caretto

A³

et al. 1985

Dermatology

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The frequency of autoimmune disorders was determined in 373 vitiligo patients and in controls matched for sex, age and race. Vitiligo patients had an increased frequency of clinical autoimmune diseases of thyroid (7.5%), stomach (0.8%), parathyroid (1%), adrenal gland (1.3%). Vitiligo patients, without clinical signs of overt autoimmune diseases, also had a statistically significant increase in the frequency of gastric parietal cell (p < 0.001), thyroid microsomal (p < 0.05) and adrenal autoantibodies (p < 0.05). This increased incidence of autoimmune manifestations was correlated with the duration of vitiligo. Furthermore in 94% of the patients with parietal cell autoantibodies a gastric biopsy showed atrophic gastritis. In addition, in 48% of the patients with thyroid microsomal autoantibodies and in 2 out of 6 patients with adrenal autoantibodies without overt diseases at the beginning of the study, the functional investigation of the target organs during the follow-up allowed the detection of the presence or that of the subsequent development of clinical or subclinical dysfunction.

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Section: Methodsmentioning

confidence: 99%

Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo

Betterle

Caretto

A³

et al. 1985

Dermatology

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“…Autoimmu nity is a well-recognized etiology in thyroid disease, where antibodies to thyroid antigens can produce a range of disorders extending from stimulation to destruction of the gland [1], Chronic urticaria is an uncommon manifestation of thyroid disease, until now found only in patients with hyperthyroid ism. It has been proposed that it might be related to the autoimmune reactions occur ring in these patients [2], In vitiligo, recent studies have demonstrated autoantibodies to melanocytes in a few patients [3,4], A signif icant association between thyroid disease (hyperthyroidism, Graves' disease) and vi tiligo has been found by several authors [5,6],…”

Section: Introductionmentioning

confidence: 99%

A Case of Chronic Urticaria and Vitiligo, Associated with Thyroiditis, Treated with PUVA

Midelfart¹,

Moseng²,

Kavli³

et al. 1983

Dermatology

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A case of chronic urticaria and vitiligo, associated with thyroiditis is described. Significantly elevated thyromicrosomal antibodies were found. Autoimmune reaction is a possible cause of the patient’s thyroid disease, vitiligo and chronic urticaria. Following PUVA treatment with a total dose of 300 J/cm² the patient’s urticaria subsided in all irradiated areas, only to relapse 2 weeks later. Subsequently courses of PUVA gave periods of remission. The treatment also induced repigmentation in the vitiliginous spots. The results indicate a local PUVA effect upon mediators or mediator-containing cells.

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“…26 Organ specific antibodies such as anti-microsomal and anti-thyroglobulin (anti-Tg) antibodies have been demonstrated in 50% and 40% of patients with vitiligo, as well as anti-thyroid antibodies in the relatives of these patients. 27 Dave et al showed antibody positivity (anti-Tg, anti-TPO) in 31.4% of their cases in India against 10% of their controls. 15 In our study the anti TPO antibody positivity was more common in women in both the vitiligo and the control groups, though not statistically significant.…”

Section: Discussionmentioning

confidence: 96%

Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

Jishna¹,

Binitha²,

Latheef³

et al. 2017

Int J Res Dermatol

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Background: Vitiligo is associated with various autoimmune diseases, including autoimmune thyroid disease. The objectives of the present study was to determine the prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in patients with vitiligo, and to compare the clinical profile of anti-thyroid peroxidase positive and anti-thyroid peroxidase negative patients.Methods: A cross-sectional comparative study was conducted in 100 patients with vitiligo and 100 controls. After dermatologic and systemic evaluation, serum thyroid hormones and anti-thyroid peroxidase antibody levels were measured in all the subjects.Results: Thyroid dysfunction was more common in the vitiligo group (27%) than in the controls. Serum thyroid stimulating hormone abnormalities were more common in the vitiligo group (27%) than in the controls (6%). The most common thyroid dysfunction was subclinical hypothyroidism. Anti-thyroid peroxidase antibody positivity was higher in the vitiligo group (36%) when compared to the controls (24%), and the most common type of vitiligo was vitiligo vulgaris (18%) in this group. Thyroid dysfunction and anti-thyroid peroxidase positivity were more common in women (58%) when compared to men (42%). There was a significantly higher prevalence of other autoimmune diseases in the vitiligo group (20%) compared to the controls (6%). Conclusions: This study shows a significant association between vitiligo and thyroid dysfunction, anti-thyroid peroxidase antibodies and other autoimmune diseases. We recommend that thyroid evaluation and regular follow-up should be done in patients with vitiligo for prompt detection of thyroid dysfunction.

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Vitiligo and autoimmune polyendocrine deficiencies with autoantibodies to melanin-producing cells

Cited by 15 publications

References 0 publications

Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo

Incidence and Significance of Organ-Specific Autoimmune Disorders (Clinical, Latent or only Autoantibodies) in Patients with Vitiligo

A Case of Chronic Urticaria and Vitiligo, Associated with Thyroiditis, Treated with PUVA

Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

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