Vitamin D3 mitigates autoimmune inflammation caused by activation of myeloid dendritic cells in SLE
Mingfang Li,
Li Luo,
Chuanchuan Lin
et al.
Abstract:Systemic lupus erythematosus (SLE) is an autoimmune disease in which defective T cells, immune complex deposition and other immune system alterations contribute to pathological changes of multiple organ systems. The vitamin D metabolite c is a critical immunomodulator playing pivotal roles in the immune system. Epidemiological evidence indicates that vitamin D deficiency is correlated with the severity of SLE. Our aim is to investigate the effects of 1,25(OH)2D3 (VitD3) on the activation of myeloid dendritic c… Show more
“…increasing the release of TNF-α and the downregulation of IL-10. On the other hand, co-culture of these myeloid dendritic cells with calcitriol showed opposite effects on TNF-α (downregulation) and IL-10 (upregulation), suggesting a role for calcitriol in mitigating inflammation also in vivo [5].…”
The second Special Issue of Nutrients dedicated to “Vitamin D, Immune Response, and Autoimmune Diseases” will include original data and recent achievements from authors who would like to participate in this research topic [...]
“…increasing the release of TNF-α and the downregulation of IL-10. On the other hand, co-culture of these myeloid dendritic cells with calcitriol showed opposite effects on TNF-α (downregulation) and IL-10 (upregulation), suggesting a role for calcitriol in mitigating inflammation also in vivo [5].…”
The second Special Issue of Nutrients dedicated to “Vitamin D, Immune Response, and Autoimmune Diseases” will include original data and recent achievements from authors who would like to participate in this research topic [...]
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